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Biomedical subjects

L Stika

Publications and source records attributed to L Stika.

At least 37 records · Page 2Linked to original sources

Patterns in drug utilization--national and international aspects: antidiabetic drugs.

Data on the prevalence of diabetes in the Czech socialist republic and on the age and sex structure of the diabetic population are presented in this paper as well as the distribution of patients according to type of therapy. The time period studied was 1972 through 1980. The following factors were supposed to affect the level of antidiabetic drug consumption in Czechoslovakia: prevalence of diabetes; organisation of health care; demographic indices and therapeutic traditions. Differences in age and sex structure of the population are probably a major reason for the observed differences in antidiabetic drug consumption between the Czech and the Slovak socialist republics. A good reciprocity was found between the sale of antidiabetic drugs measured as number of defined daily doses (DDD) per 1 000 inhabitants per day and the prevalence of diabetics treated with the corresponding drugs.

Adolescent↗

Changes in electroretinogram and serum potassium during L-DOPA treatment in parkinsonism.

The relationship of L-DOPA plasma level, parameters of ERG and severity of extrapyramidal symptoms after a single dose of L-DOPA was investigated in 11 patients suffering from parkinsonism of idiopathic or arteriosclerotic origin. After a drug-free night, each patient received his/her usual morning dose of L-DOPA. In the subsequent 3 h, the ERG recordings, blood levels and clinical ratings of extrapyramidal symptoms significantly dropped after a delay of 60 min in relation to the occurrence of the peak plasma L DOPA level. The initial "b" wave amplitudes as well as initial serum potassium values were abnormally high. There was a statistically significant correlation between the decrease of "b" wave amplitude (delta "b") and the potassium "normalization index" (i.e. the ratio between the observed decrease of serum potassium and the pretreatment difference from the middle normal potassium value). A definite interpretation of the data cannot be provided until more knowledge about the origin of "b" wave of ERG is available. It can be concluded tentatively that dopaminergic processes influence electrophysiological reactivity of the retina.

Aged↗