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Biomedical subjects

L Steardo

Publications and source records attributed to L Steardo.

At least 91 records · Page 5Linked to original sources
PubMed1980

[DPA and clonazepam activity in febrile convulsions: preliminary results].

A pharmacological trial has been performed for the prophylaxis of febrile convulsions in childhood. The administration of two antiepileptic drugs, Sodium Valproate and Clonazepam, reduces significantly seizures occurrence compared with unmedicated controls. Furthermore, Sodium Valproate has been found to be more effective than Clonazepam. Both anticonvulsants are thought to act by a Gabaergic modulation in CNS.

Benzodiazepinones↗
PubMed1980

[Circadian rhythm of free tryptophan in healthy human volunteers].

Daily rhythms of free plasma tryptophan in man are reported from a study in twelve normal volunteers on stated dietary and environment conditions. Measurements of tryptophan were been obtained according to Bloxam's modifications of traditional methods. The Authors describe the results and discuss the importance of free plasma tryptophan levels as a marker of 5-HT brain metabolism.

Adolescent↗
PubMed1980

[Lithium therapy in Horton's neuralgia: preliminary results].

Prophylactic use of Lithium salts in patient suffering from cluster headaches has been evaluated looking at the mean number of headache attacks in one critical period and the mean weekly duration of the period itself. These two elements have been compared to those observed on other drugs treatments. Plasma Lithium monitoring has been performed weekly during the trial. Authors discuss the results reported and the hypothetic basis of them.

Cluster Headache↗
PubMedDate not supplied

Prophylaxis of migraine attacks with a calcium-channel blocker: flunarizine versus methysergide.

In this study, flunarizine, a selective calcium-channel blocker, was employed in the prophylactic treatment of headache and was compared with methysergide in terms of efficacy. The trial was conducted with 104 patients (53 treated with flunarizine and 51 treated with methysergide) and lasted six months--one month of pretreatment and five months of therapy. Patients in both groups experienced a highly significant reduction in the number and duration of migraine attacks. Unlike those in the methysergide group, patients treated with flunarizine achieved a significant reduction in the intensity of attacks with very negligible side effects.

Adult↗
PubMedDate not supplied

Cholecystokinin octapeptide analogues stable to brain proteolysis.

Based on recent findings identifying the initial degradative cleavage of CCK-8 at the Met3-Gly4 bond by a metalloendopeptidase, two analogues of CCK-8 with D-Ala and D-Trp substitutions at the Gly4 position were synthesized as stable analogues. Their stability to proteolysis by brain membranes and their binding potency at central CCK receptors were quantified. Both peptides are stable to degradation by peptidases in cortical synaptic membrane preparations. The analogues are nearly equipotent to CCK-8 in their affinities for inhibition of 125I-CCK-33 binding to guinea pig cortical membranes. L-Ala and L-Trp substituted peptides were synthesized for comparison. Both these peptides are degraded by synaptic membranes and the L-Trp substituted peptide possesses a greatly reduced affinity for central CCK receptors. Therefore, the structure of CCK due to the D conformation of Gly is more capable of interacting with brain CCK receptors. Further conformational analysis will establish whether the stabilized structure is a beta-bend or a beta-turn. Since these peptides are highly potent and stable to brain proteolysis they may be useful as stable CCK analogues for in vivo application.

Animals↗
PubMedDate not supplied

Long-term treatment with carbamazepine affects CSF somatostatin immunoreactivity in epileptic patients.

A number of pharmacological evidence supports the view that somatostatin (SS) may be importantly involved in the seizure susceptibility both in humans and in laboratory animals. In a previous report the Authors have provided the finding that a short-term carbamazepine (CBZ) administration is able to reduce SS-CSF-IR in epileptic patients. The present study has been carried out to investigate whether a long-term treatment with CBZ affects in a similar way SS-IR content in CSF from temporal lobe epileptics (CPS). The results confirm and expand previous evidence suggesting that CBZ lowering effect on CSF-SS-IR may be relevant to its anticonvulsivant action.

Carbamazepine↗