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Biomedical subjects

L Sprincl

Publications and source records attributed to L Sprincl.

At least 19 recordsLinked to original sources
PubMed1989

[Immunohistochemical classification of hypophyseal adenomas].

Immunohistochemical analysis showed production of hormones in more than half of 88 pituitary adenomas that were classified mostly as chromophobe in basic staining during 3 years. Prolactin was the most often detected. A combined production of hormones especially of prolactin and growth hormone was not exceptional. Using a sensitive double indirect immunoperoxidase technique enables economy in spending primary antibodies. Evaluation of hormonal production is important for selection of therapy, as well as for settlement of prognosis.

Adenoma↗
PubMed1987

Patterns of in vitro behaviour characterizing cells of spontaneously metastasizing K2M rat sarcoma.

Cells of K2M rat sarcoma and their descendants (RP, RPS) form tumours in syngeneic inbred rat strain LEW/CUB. Thirty to fifty per cent of tumour-bearing rats develop metastases, preferentially in the lung. In vitro, a quasi-stellate dynamic morphotype was characteristic of K2M cells and their descendants (RP, RPS): a highly changeable round or spindle-shaped or multipolar rather thick cell body with two or more protrusions of various length, often branching, and broadened at the tips, where vivid membrane activity was observed. Changeability of appearance and directionality of locomotion were stimulated in medium of pH 6.5. The enhanced expression of this morphotype correlated with the increased metastatic potential. In vitro, in poor, slightly acid medium metastasizing cells preserved the quasi-stellate dynamic morphotype and survived longer than non-metastasizing cells. It is likely that the observed combination of traits, viz. the quasi-stellate dynamic morphotype and, under unfavourable conditions, prolonged survival, increased migratory activity and decreased mitotic rate could be of significance in the metastatic cascade, mainly for the escape from the primary site.

Actins↗
PubMed1985

[Use of a computer program in the diagnosis of brain tumors].

The FEL-EXPERT was used to improve the diagnosis of brain tumors. Basic structure and decision process of the system were characterized. In a group of 70 testing cases the correct diagnosis was established at the 1st possibility in 83%, as the 1st or 2nd possibility in 91% and as the 1st or 2nd or 3rd possibility in 17%.

Artificial Intelligence↗
PubMed1984

[Carcinoma of the hypophysis with acromegaly].

A 38-year old man deceased after being operated on recurring pituitary adenoma removed 13 years ago. Autopsy showed a massive spread of tumour on dura and in subarachnoid space. Growth hormone producing cells were found prevailing in the primary tumour as well as in secondaries by immunohistochemistry and immunofluorescence which concurred with acromegaly. Many cells produced prolactin. The tumour spreading discontinually in subdural and subarachnoid space was taken for a carcinoma.

Acromegaly↗
PubMed1982

The biocompatibility of polypyrrolidone in test implantation.

The biological compatibility of polypyrrolidone was investigated using subcutaneous implantation in rats. Acute (10 days) and chronic (360 days after implantation) tissue reaction was characterized numerically and compared with poly(2-hydroxyethyl methacrylate), used in the Drug Control Research Institute in Prague as a standard in the evaluation of polymers, for which good tolerance in the clinical practice has been demonstrated. Surface changes in the polymer were evaluated by using a scanning electron microscope.

Animals↗
PubMed1981

Unusual electron microscopy findings in liver biopsies from patients with viral hepatitis B.

Electron microscopy of 57 needle biopsies from livers of 55 patients with chronic hepatitis, mostly of type B, revealed, in addition to typical hepatitis B virus nucleocapsids in 34 cases, also atypical intranuclear inclusions in 9 biopsies. These inclusions consisted of electron-dense particles similar in size to hepatitis B virus nucleocapsids. The possibility of an involvement of a hepatitis non-A non-B virus is discussed.

Adult↗