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Biomedical subjects

L Spitz

Publications and source records attributed to L Spitz.

At least 235 records · Page 13Linked to original sources
PubMed1984

Transport of the surgical neonate.

We have shown that the critically ill neonate may be safely transferred over long distances provided some essential criteria are fulfilled. There are obvious advantages in centralising neonatal surgery in a limited number of regional centres where surgical expertise and adequate support services are concentrated and there seems to be no justification, except in situations of dire emergency, for neonatal surgery to be performed in district general hospitals in the United Kingdom. The fact that neonates requiring surgery can be safely transferred adds strength to the plea for the paediatric surgeon to have an absolute monopoly of surgery in this age group.

Body Temperature↗
PubMed1984

Extrahepatic biliary obstruction due to stone.

Jaundice developing after the neonatal period requires prompt investigation. Surgical causes of cholestatic jaundice, apart from extrahepatic biliary atresia and choledochal cyst, are rare. We describe a case of bile duct dilatation associated with an impacted calculus at the ampulla of Vater in a haemophiliac. The ultrasound finding of a dilated duct was an indication to proceed to surgery.

Cholelithiasis↗
PubMed1984

Peptic ulceration in children.

An analysis of 84 children with peptic ulcer disease seen at The Hospital for Sick Children, in London, revealed only 30 primary ulcers over a period of 30 years. While most of these responded to conservative measures, it is recognized that a significant proportion may ultimately require surgical treatment for recurrence of the disease in adult life. Secondary ulcers occurred with almost twice the frequency of primary disease. Hemorrhage was the first sign of the ulceration in 55 per cent of these seriously ill children and could be controlled with conservative measures in 14 of 17 patients. Only three patients required surgical treatment for uncontrolled hemorrhage. Secondary ulceration was largely a terminal event and despite intensive resuscitation carried a high mortality (77.7 per cent).

Child↗
PubMed1983

Detection and affinity purification of beta-endorphin precursors using a monoclonal antibody.

A monoclonal antibody to porcine beta-lipotropin has been produced which binds to the N-terminal (gamma-lipotropin) portion of the molecule. The antibody can be used to detect beta-lipotropin as well as other beta-endorphin precursors (predominantly a Mr 38 000 polypeptide) using radiobinding assay or the immunoblotting technique. Purification of the peptides can be readily achieved by affinity chromatography using the monoclonal antibody covalently bound to Sepharose 4B. As the antibody recognises the N-terminal part of beta-lipotropin, it can be used to detect and purify beta-lipotropin and other beta-endorphin precursors in the presence of beta-endorphin.

Animals↗
PubMed1983

A comparison of Nissen fundoplication and Boerema gastropexy in the surgical treatment of gastro-oesophageal reflux in children.

The results of surgical treatment of gastro-oesophageal reflux in 133 infants and children clearly demonstrated the superiority of the Nissen fundoplication over the Boerema gastropexy. The failure to control reflux in the gastropexy group (50 patients) was 42 per cent compared with a 9.6 per cent failure rate in the fundoplication group (83 patients). This resulted in a reoperation rate of 24 per cent for the gastropexy procedure compared with 8 per cent for the fundoplication. There was no difference in the incidence of postoperative complications.

Child, Preschool↗
PubMed1983

Hypocalcaemic seizures following gastrectomy.

Two cases of hypocalcaemia following removal of the stomach due to complications of surgery for tracheo-oesophageal anomalies are reported. In both instances grand mal seizures were the presenting features with radiological and biochemical evidence of rickets. Both children had elevated blood parathyroid hormone levels. The bone changes, hypocalcemia and symptoms responded to parenteral vitamin D therapy. Sub total gastrectomy is a rare event in infancy and consequently no previous cases of vitamin D lack has been recorded as a complication of gastric surgery in this age group.

Child↗
PubMed1983

Obstructive jaundice secondary to chronic midgut volvulus.

A case of progressive extrahepatic biliary obstruction due to chronic midgut volvulus secondary to malrotation in a 5-month-old girl is presented. The obstruction to the bile duct was relieved after correction of the malrotation and division of the obstructing bands.

Cholestasis, Extrahepatic↗
PubMed1982

Antibodies to poliovirus detected by immunoradiometric assay with a monoclonal antibody.

An immunoradiometric assay (IRMA) for the assay of antibodies to poliovirus antigens is described. Dilutions of the test sera or whole (finger prick) blood samples were incubated with the Poliovirus antigen bound to a solid phase and the specific antibody was detected by the addition of a mouse anti-human IgG monoclonal antibody (McAb), which was itself revealed by iodinated sheep IgG anti-mouse F(ab). We have shown that this technique is suitable for the estimation of IgG anti-poliovirus antibodies induced in children following polio vaccine. The present study shows that SPRIA provides a simple and inexpensive method for serological studies with poliovirus particularly for use in large-scale surveys.

Antibodies, Monoclonal↗
PubMed1982

A comparative study of scalpel and electrosurgical incision on subsequent wound healing.

The mechanical strength of incisions in the anterior abdominal wall using either scalpel or electrocautery was compared by measuring the bursting stresses of the resulting wounds. Statistically significant differences were shown to occur in the first and thirty-fifth postoperative days. Between the seventh and tenth postoperative days, when wound dehiscence is most likely to occur, no difference in the rupture strength could be detected.

Animals↗
PubMed1982

Surgical treatment of gastrooesophageal reflux in severely mentally retarded children.

Twenty severely mentally retarded children with significant gastrooesophageal reflux were submitted to surgical treatment. In all patients vomiting was present to a distressing degree in 5 children, 3 of whom required extensive surgery to overcome the obstruction. All had failed to respond to conservative measures. Although the postoperative complication rate was high (50%), the final result in the majority of patients was highly satisfactory.

Adolescent↗