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Biomedical subjects

L Spätling

Publications and source records attributed to L Spätling.

51 records · Page 3Linked to original sources
PubMed1982

The effect of indomethacin on spontaneous and human menopausal gonadotropin induced pressure changes in the tissue and arterial vascular system from human ovaries perfused in vitro.

Eight human ovaries were perfused in a closed recirculating system with a semisynthetic, hemoglobin-free medium. Arterial and intraovarian pressures were recorded simultaneously. In three experiments spontaneous pressure changes were noticed. In five experiments pressure changes were induced with human menopausal gonadotropin (hMG) (approximately 70mIU/ml follicle stimulating hormone (FSH) and 40mIU/ml luteotrophic hormone (LH) II. IRP-hMG). Frequency and amplitude of pressure changes in the arterial system and fluctuations in tissue pressure were reduced with indomethacin (20 micrograms/ml). In one experiment 40 micrograms/ml indomethacin had been used. In spite of the high dose of indomethacin arterial and tissue pressure changes were not abolished in all experiments. Therefore it is assumed that vascular and tissue activities are not mediated by prostaglandins only.

Adult↗
PubMed1981

[Oral magnesium therapy in cases of preterm labour (author's transl)].

19 patients with preterm labour received an oral application of 20-30 mval/d Magnesium in addition to the common Fenoterol-Verapamil tocolysis. This therapy showed the following results: 1. augmentation of the Mg2+ serum level from 1.48 to 1.7 mval/l, 2. significant reduction of contraction frequency (p less than 0.005), 3. significant reduction of Fenoterol dose (p less than 0.005), 4. in 14 patients it was possible to change from parenteral to oral therapy.

Administration, Oral↗
PubMed1980

[Increased hair growth during prolonged tocolytic therapy with fenoterol. Measurements of testosterone, androstandiol, cortisol and ACTH (author's transl)].

28 patients out of 30 treated with a longtime i.v. infusion of Fenoterol showed an intensive hair growth all-over the skin not especially showing the Linea alba and the beard. To investigate the normal hair growth during pregnancy we examined 384 volontiers just before delivery. 2,8% showed an android hair growth and 3,6% a more intensive hair growth all over the skin. To investigate the role of hormones in the excessive hair growth following i.v. tocolysis with Fenoterol, we measured Testosterone, 5 a-androstan-3 beta-17 beta-diol, Cortisol and ACTH. In contrast to the reports in literature we found a decrease in Testosterone during the treatment with Fenoterol. After an initial fall Androstandiol showed a slight rise in the 3rd week of therapy. ACTH and Cortisol remained unchanged. Contrary to the literature we did not see any augmentation of plasma Cortisol. We conclude, that androgen metabolites are not the reason for the intensive hair growth. The hair growth may be due to a more intensive metabolism within the hair follicle.

Adolescent↗
PubMed1978

[Measurements of spontaneous pressure changes in the arterial vessels and in the tissue of bovine ovaries perfused in vitro (author's transl)].

12 bovine ovaries were perfused in a closed circuit system using a semisynthetic hemoglobinfree perfusate. The pressure in the ovarian tissue and the arterial pressure were recorded simultaneously. Arterial and tissue pressure changes were noticed in bovine ovaries, as have been described in other species. It could be shown that pressure in the vascular system and the arterial pressure may vary independently. It appears as if spontaneous pressure changes in the in vitro perfused ovary are more pronounced in frequency and amplitude during the phase of follicle maturation.

Animals↗
PubMed1977

[Studies on the dependence of intrafollicular pressure on the pressure in the intraovarian-vascular-system and tissue, carried out in vitro on human ovaries (author's transl)].

The intrafollicular, intraovarian and intraarterial hydrostatic pressures were measured in vitro on human ovaries in the vollicular ripening phase. It has been established that in the vascular system as well as in the intraovarian tissues pressure variations occur spontaneously. Thus for example under, the influence of epinephrine, norepinephrine, prostaglandine F2 alpha and oxytocine, the tonicity of the vascular system increases and does so the number of spontaneous contractions rather noticeably, particularly under the influence of prostaglandine F2alpha, and under the various catecholamines an increase of frequency and amplitude has been observed. Any increase of pressure in the intraovarian vascular system and tissues will effect all the follicles not yet in the preovulatorian phase, in which they cause a similar pressure increase. However, follicles imminently preovulatorian have not shown such pressure increase because the increase of the "liquor folliculi" runs parallel to the increasing elasticity of the follicle walls. The findings are discussed in this article with a particular view of the biophysical aspects of ovulation.

Adult↗
PubMed1976

Investigations into the preservation of human ovaries by means of a cryoprotectivum.

Human ovaries in the phase of follicular ripening were treated by means of a cryoprotectivum immediately after their removal. They were kept at --18degrees C for up to 8 weeks. After having gradually been thawed the ovaries were in vitro connected to a perfusion system. When completely revitalized they were examined in the steady-state for their metabolic behaviour. It was found that in comparison with the untreated controls, depending on the period of preservation, the oxygen consumption and the estrogen secretion had decreased, while the glucose absorption and lactate production had increased. As a morphological substrate a minor oedema was established in the tissue in the histological control after a preservation period of 2 months. This was mainly localized around the arteries. The method can be regarded as suitable for the preservation of ovaries for a limited period of time. It is possible to maintained a metabolism that can still be regarded as functioning.

Adult↗
PubMedDate not supplied

Breast size as risk factor for tumor size at diagnosis.

BACKGROUND: A prospective study was conducted to determine whether patients with larger breasts show larger tumors. MATERIALS AND METHODS: 123 patients with primary breast cancer were evaluated (median follow-up 36 months). Breast size was determined as a reflection of cup size. RESULTS: Cup size correlated with tumor diameter at diagnosis (p = 0.0038). On average, cup sizes were larger in postmenopausal than in premenopausal women (p = 0.0011), however, postmenopausal women did not show larger tumors than premenopausal. There was a significant positive correlation between body mass index, body weight and breast size (p < 0.0001). The mode of tumor detection (self vs. not self) was independent of breast size. No correlation was found between breast size and the patient's height, duration of breast feeding, smoking behavior or amount of alcohol consumption, hormone replacement therapy or use of oral contraceptives, number of involved lymph nodes or DFS and OS. CONCLUSION: Patients with larger breasts showed larger tumors. The mode of tumor detection is independent of breast size.

Adult↗
PubMedDate not supplied

Four-channel tocography in uneventful pregnancies: a prospective study in primigravidas and multigravidas.

OBJECTIVE: The simultaneous recording of external uterine pressure in four locations on the abdominal wall with four-channel-tocography provides new ways to describe the dynamics of uterine activity. METHODS: Fifty-eight healthy primigravidas and 25 healthy multigravidas were studied prospectively with four-channel tocography during the course of pregnancy. Starting at 21 weeks' gestation, the following five intervals were defined: 21-24, 25-28, 29-32, 33-36 and more than 37 completed weeks. Eligibility criteria included informed consent, no history of malformations of the uterus, and no previous preterm deliveries. Patients were excluded for the following reasons: medication for preterm labor, cerclage, placenta previa, delivery before 37 weeks' gestation, less than three measurements completed, and patient's withdrawal of consent. RESULTS: The median contraction frequency per hour was six for primigravidas and five for multigravidas, without significant correlation with gestational age. At all time periods studied, the median rate of global contractions developing simultaneously in at least three uterine segments was less than 15%; however, it was significantly higher in primigravidas than in multigravidas (14% versus 4%, P <.001). Both groups had more activity in the right upper quadrant of the uterus shortly before delivery. CONCLUSION: Four-channel tocography provided insight into uterine activity patterns and might enable obstetricians to select clinically relevant contractions for further treatment.

Adolescent↗
PubMedDate not supplied

[Significance of the site of uterine contraction for labor progress and duration of pregnancy].

A four-channel topographic technique was developed in order to improve information about spatial uterine motility. 54 women were monitored during delivery. Four pressure transducers were attached in a square around the umbilicus. Most frequently the origin of labour could be determined in the upper right segment of the uterus. The rate of operative deliveries was decreased in case of predominant upper right origin of labour. The majority of contractions with clear propagation patterns originated at the upper right site, continued to the left and then to the lower right part of the uterus. The highest relative intensity was also measured at the upper right site. Predominant upper right origin of labour may be important for undisturbed delivery. The probability of a preterm delivery is increased in case of an upper right origin of labour.

Adult↗
PubMedDate not supplied

[Fetal movements in 4-channel tocography].

INTRODUCTION: The four-channel-tocography was developed to register the spatial and temporal pattern of uterine contractions and to evaluate their clinical relevance. In this study it should be assessed whether the four-channel-tocography can also register fetal movements. MATERIAL AND METHODS: The study included 38 women with a gestational age between 28 and 43 weeks and singleton pregnancy. Four pressure transducers were attached in a square around the umbilicus. Parallel to the continuous registration of four-channel-tocography fetal movements were observed by conventional ultrasound. RESULTS: In a total of 23 hours and 11 minutes 403 fetal movements were registered by ultrasound and 405 by four-channel-tocography. 17% of the ultrasonically observed fetal movements were documented by the four-channel-tocography and 70% of the tocographically registered movements could be verified by ultrasound. CONCLUSION: Fetal movements can be registered by four-channel-tocography with good sensitivity and reliability. Essential for its clinical use is an automatic analysis, which is being developed.

Female↗