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Biomedical subjects

L Sobin

Publications and source records attributed to L Sobin.

12 recordsLinked to original sources
PubMed1999

Loss of heterozygosity at 1p36 predicts poor prognosis in gastrointestinal stromal/smooth muscle tumors.

Gastrointestinal stromal/smooth muscle tumors are uncommon neoplasms for which current criteria for diagnosing malignancy (size and mitotic index) sometimes fail to predict outcome. Cytogenetic studies reveal frequent chromosome 1 abnormalities in these tumors, but significant underlying molecular changes have not been elucidated, and their significance is unknown. DNA was obtained from the formalin-fixed, paraffin-embedded tissue of 80 gastrointestinal stromal/smooth muscle tumors. Tumors were topographically microdissected from surrounding normal tissue; microsatellite markers from tumor and normal tissue were amplified by PCR in the regions of chromosome 1p36 (D1S199, D1S228, D1S450, D1S214, D1S243), 1p12 (D1S418),1p13 (D1S252, D1S514), and 1q32(D1S103). The presence or absence of heterozygosity for each case was mapped at each informative marker. Relationships among loss of heterozygosity (LOH), tumor size, mitotic index, and survival were investigated using correlation analysis, Kaplan-Meier plots, and the Cox model. LOH at 1p36 was found in 24 of 80 cases, suggesting the possibility of a tumor suppressor gene at 1 p36 near the site of a suspected neuroblastoma tumor suppressor gene. Patients whose tumors demonstrated LOH at 1 p36 had significantly shorter survival (p = 0.017) than those whose tumors did not. LOH at 1 p36 retained independent prognostic significance in a multivariate model that included KIT mutation status and tumor size; the mitotic index, however, did not retain independent significance in such a model. LOH was observed at 1 p12-1p13 (most frequently at 1p13.3) in 19 of 80 cases, but loss of heterozygosity at this site did not influence survival. No LOH was observed near 1q32. These findings provide strong evidence for a prognostically significant tumor suppressor gene in the region of chromosome 1p36.3.

Base Sequence↗
PubMed1986

National cancer control programs and setting priorities.

Although considerable resources are being allocated globally to cancer research, efforts to implement these findings efficiently are lagging behind. Enough is known about the cause of common tumors such as lung, oral, and liver cancer to allow active measures to be taken for their prevention. Effective early detection programs have been developed for cervical, breast, and oral cancer, and treatment methods exist whereby at least one-third of all cancer patients can be cured if their disease is detected early. Unfortunately, however, most cancer activities currently in place were developed haphazardly and lack overall coordination. National cancer control efforts can be more effectively planned and implemented if they follow a systematic stepwise approach of assessing the current situation, setting health objectives, evaluating the possible strategies, and setting priorities using quantitative assessments. Cancer affects both developed and developing countries of the world, and well planned national efforts emphasizing prevention and early detection can significantly reduce the cancer problem.

Adolescent↗
PubMed1983

Surveillance, epidemiology, and end results lung cancer data applied to the World Health Organization's classifications of lung tumors.

Less than 1% of the lung cancer cases from the Surveillance, Epidemiology, and End Results (SEER) Program changed categories as a result of the World Health Organization's revision of histologic classifications of lung tumors. Of the 28,119 microscopically proved lung cancers reported to SEER in 1977-79, 32% were squamous cell carcinoma, 16% were small cell and/or oat cell carcinoma, 27% were adenocarcinoma, 8% were large cell carcinoma, and 5% were other specified types. A further 12% (approximately 3,500 cases) were reported with such nonspecific terms as bronchogenic carcinoma, carcinoma of the lung, and undifferentiated or anaplastic carcinoma. The magnitude of the use of these nonspecific terms showed the need for greater precision in reporting and recording data.

Carcinoma↗
PubMed1973

A proposal for a standardized system of reporting human lymph node morphology in relation to immunological function.

This memorandum proposes a standardized system of reporting the histology of human lymph nodes based on commonly used simple staining techniques. The purpose is to provide a uniform, internationally acceptable system by which the histological structure of lymph nodes can be correlated with other parameters of immunological status. The proposed protocols are intended to provide information that is not available in conventional written reports that use such terms as ;hyperplasia' or ;nonspecific lymphadenitis'.

Agammaglobulinemia↗
PubMed1972

A proposal for a standardized system of reporting human lymph node morphology in relation to immunological function.

This Memorandum proposes a standardized system of reporting the histology of human lymph nodes based on commonly used simple staining techniques. The purpose is to provide a uniform, internationally acceptable system by which the histological structure of lymph nodes can be correlated with other parameters of immunological status. The proposed protocols are intended to provide information that is not available in conventional written reports, that use such terms as "hyperplasia" or "nonspecific lymphadenitis".

Histiocytes↗