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Biomedical subjects

L Sirovich

Publications and source records attributed to L Sirovich.

26 records · Page 2Linked to original sources
PubMed1985

Linearity of hue cancellation in sex-linked dichromacy.

The results of several recent studies concur in the finding that for normal trichromats red-green hue-cancellation data obey linearity properties over rather general conditions, but for most observers yellow-blue hue-cancellation data do not. It is of interest to examine the question of cancellation linearity in sex-linked dichromats under the assumption that they represent reduced systems. We measured both the wavelength of the spectral achromatic point over a large range of intensities and yellow-blue hue-cancellation functions over the full spectrum and at several luminance levels in protanopes and deuteranopes. Both sets of data for the two types of dichromat satisfy linearity properties. These results are consistent with a model in which both cone receptor response functions have the same form. Implications for trichromatic opponent-response functions are considered.

Color Perception Tests↗
PubMed1979

Effect of boundaries on the response of a neural network.

The effect an abrupt boundary has upon the dynamical response of a neural network is investigated. The retina of the Limulus eye is used as a model system for studying this effect. A theoretical technique is presented for the quantitative prediction of the manner in which this neural network responds in the vicinity of its boundary. Corresponding experimental measurements of the response to moving stimuli by single optic neurons located near retinal boundaries are presented. Theory and experiment show detailed quantitative agreement.

Animals↗
PubMed1979

Treatment of nerve impulse data for comparison with theory.

A procedure is given for the comparison of nerve impulse data with model predictions. This method utilizes information in the nerve impulse train that is ignored by the post-stimulus-onset histogram and thereby gives an improved signal-to-noise ratio. Comparison of observed responses in the Limulus retina with predictions derived from a detailed model gives good agreement.

Action Potentials↗
PubMed1977

On some mathematical techniques for the analysis of visual spectral sensitivities.

Starting from known spectral properties of visual photopigments and photoreceptors, a mathematical construction of neural response functions to visual stimuli is obtained. Included in this is a somewhat general derivation of the univariance principle. Temporal dependence of response on stimulus is included in the formulation. Special attention is given to the case of flash stimuli and their resulting spectral sensitivities. This formulation is applied to certain physiological spectral sensitivity measurements that are at variance with known spectrophometric results. An analysis of the data in these cases suggests that they correspond to "pseudo-pigments" arising from the neural interaction of several photopigments. The method of analysis is constructive and identifies the gamma-max's of the interacting photopigments. These are found to be in good agreement with existing spectrophotometric measurements.

Animals↗
PubMed1977

On subthreshold solutions of the Hodgkin-Huxley equations.

Subthreshold solutions of the Hodgkin-Huxley equations are considered here by means of the linearized forms of these equations. An asymptotic theory is obtained, based on dimensional analysis and scaling arguments. Explicit expressions for the crest speed are obtained and are shown to be in good agreement with experiment, with computation, and with an exact asymptotic value which is also obtained here.

Action Potentials↗
PubMedDate not supplied

On the simulation of large populations of neurons.

The dynamics of large populations of interacting neurons is investigated. Redundancy present in subpopulations of cortical networks is exploited through the introduction of a probabilistic description. A derivation of the kinetic equations for such subpopulations, under general transmembrane dynamics, is presented. The particular case of integrate-and-fire membrane dynamics is considered in detail. A variety of direct simulations of neuronal populations, under varying conditions and with as many as O(10(5)) neurons, is reported. Comparison is made with analogous kinetic equations under the same conditions. Excellent agreement, down to fine detail, is obtained. It is emphasized that no free parameters enter in the comparisons that are made.

Action Potentials↗