Teratoma of the head and neck in infancy.
Explore the source record for details and available documents.
Head and Neck Neoplasms↗
Biomedical subjects
L Sirota
Publications and source records attributed to L Sirota.
X-ray microanalysis of the fingernails in term and preterm infants.
The element content of the fingernails of 10 term and 14 preterm infants, clipped for the first time after delivery, was determined by x-ray microanalysis. The results showed a decrease in sulfur and aluminum, and a higher chlorine content in term infants in comparison with preterm ones, the difference being statistically significant. Sodium, potassium, calcium, and zinc content did not differ in the two groups. Copper, iron, magnesium, aluminum, and phosphorus were detected in trace amounts only. Cobalt was not detected in the fingernails of newborns in either group. The elevated content of aluminum in the fingernails of preterm infants may be a clue to the osteopenia observed in these infants.
Aluminum↗
In vivo and in vitro effects of theophylline on the peripheral blood mononuclear cells from preterm infants.
The in vivo effect of aminophylline (theophylline ethylenediamine) on cAMP levels and the mitogenic response of peripheral blood mononuclear cells (PBMC) from preterm infants were investigated. Increased cAMP levels and reduced response of these cells to concanavalin A (Con A) were found in preterm newborns who received intravenous aminophylline. No inhibitory effect of the drug on phytohemagglutinin (PHA)-induced proliferation was observed. cAMP levels of PBMC derived from preterm infants were significantly lower than those of term newborns. The in vitro effect of theophylline on the mitogenic response of PBMC from adults, term and preterm infants was also compared. It was found that PBMC from adults were significantly more sensitive to the inhibitory effect of theophylline on Con A-induced proliferation than were PBMC from either term or preterm infants, whereas the effect of the drug on the mitogenic response to PHA was similar in the three groups. These data suggest differences either in the sensitivity to increased cAMP concentration between PBMC from adults and newborns or in their lymphocyte subpopulations.
Adult↗
Breast milk jaundice in preterm infants.
A retrospective study was performed comparing bilirubin levels in 40 preterm newborns with uncomplicated courses fed a combination of premature breast milk and formula to those of 60 comparable preterm newborns fed formula only. A significantly higher bilirubin level was noted in the group fed the combined diet on the 6th day of life and on the day of discharge. Seventy-six and seven tenths percent of the preterm infants fed breast milk and formula met the criteria for phototherapy, whereas only 45 percent were treated in the group fed formula alone. Our findings indicate that premature breast milk might cause early and late increase in bilirubin levels in healthy preterm newborns.
Bilirubin↗
Myoglobinuric renal failure in a newborn after traumatic delivery.
Fetal and neonatal asphyxia is the main cause of transient or acute renal failure (ARF) in neonates. Rhabdomyolysis and subsequent myoglobinuria have been rarely reported in neonates. We describe a case of ARF in a newborn infant in whom asphyxia, birth trauma and hypovolemic shock precipitated rhabdomyolysis which contributed to ARF.
Acute Kidney Injury↗
[Congenital intestinal obstruction due to apple peel small bowel atresia].
Explore the source record for details and available documents.
Anastomosis, Surgical↗
Production of interleukin-1 by mononuclear cells of newborns and their mothers.
The ability of peripheral blood mononuclear cells derived from newborn infants, their mothers and healthy adults to produce interleukin 1 (IL-1) was examined. It was found that newborn and maternal mononuclear cells have a normal capacity to produce IL-1. In addition, a lower stimulatory activity of IL-1 production was found in maternal serum, suggesting another mechanism for the suppression of the maternal immune system during pregnancy. Furthermore, evidence is presented on the existence of sex-related blocking factors in the maternal serum which affect IL-1 production.
Adult↗
Difference in the placental ferritin levels measured by a specific monoclonal antibody enzymoassay in preterm and term delivery.
The use of a new monoclonal antibody (MoAb) enzymoassay for the specific measurement of placental ferritin (PLF) enabled it to be quantitatively determined in the sera of pregnant women, women at full-term and preterm delivery, and in their newborns. High levels of PLF were measured in the sera of pregnant women at 17 weeks of gestation up to full-term delivery as compared with normal adult women who mostly lack PLF. The level of PLF in the serum was irrespective of the total ferritin level. In full-term newborns, PLF concentration was lower than that found in their mothers although it increased compared to healthy adults. It was further found that in the blood of women who delivered at 29-36 weeks, PLF was undetected or was very low. Accordingly their preterm infants also exhibited very low or undetectable PLF in their serum. These results suggest the possible use of PLF as a prognostic indicator in pregnancy.
Adult↗
Proximal femoral focal deficiency associated with severe brain atrophy.
Explore the source record for details and available documents.
Atrophy↗
An infant with multiple deformations born to a myasthenic mother.
An infant with multiple deformations born to a mother with untreated myasthenia gravis presented with arthrogryposis multiplex, craniofacial dysmorphism, kyphoscoliosis of the thoraco-lumbar spine, severe hypotonia, absence of the sucking reflex, and other neurological deficits. The neurological state of the infant supported the diagnosis of congenital myasthenia gravis, but the negative Tensilon test and the lack of clinical improvement after prolonged Mestinon treatment ruled out this diagnosis. We believe that the multiple deformations and reduced fetal movements are related to the maternal myasthenic environment associated with mild polyhydramnion.
Abnormalities, Multiple↗
Rib fractures as a cause of immediate neonatal tachypnoea.
Two macroscopic term neonates are described who presented with uncomplicated tachypnoea immediately following vaginal delivery. The tachypnoea was not associated with lung injury, metabolic, endocrine or cardio-respiratory disease but with multiple unilateral posterior rib fractures. The neonatologist should be aware that neonatal tachypnoea immediately after vaginal term delivery, especially in macrosomic infants, may be caused by the pain of fractured ribs. The diagnosis can be made only by careful inspection of the ribs on chest X-ray.
Female↗
Familial vesicoureteral reflux: a study of 16 families.
Siblings of patients with vesicoureteral reflux (VUR) are reported to have an increased incidence of reflux. We present 16 families with 33 affected children out of a total of 493 patients with VUR. Twenty-seven had urinary tract infection and 6 were asymptomatic and were examined because a sibling had VUR. Renal scarring was present in 19 cases; reflux was more marked and more often bilateral in the siblings than in sporadically affected children. In view of our findings we suggest that siblings of patients with VUR be screened early for reflux to prevent renal damage from untreated VUR.
Adolescent↗
Cord serum inhibits allogeneic mixed lymphocyte reaction and stimulates lymphokine production.
An inhibitory activity on the two-way allogeneic mixed lymphocyte reaction (MLR) was detected in maternal and cord serum at delivery. The inhibitory effect of the maternal serum was found to be more pronounced and was detected in almost all sera tested, whereas the inhibitory capacity of cord sera was observed in only 70% of the cases. In addition, a lower stimulatory activity for interleukin-2 (IL-2) production was found in the maternal serum, suggesting an additional mechanism for the suppression of the maternal immune system during pregnancy. On the other hand, a higher stimulatory activity for IL-2 production was observed in cord serum as compared with adult normal serum. The possibility that a fetal humoral factor is involved in the regulation of the immune system via the stimulation of IL-2 production is discussed.
Adult↗
Neurodevelopmental and psychological aspects in a child with 49XYYYY karyotype.
Neurodevelopmental and psychological aspects in a child with 49XYYYY karotype are described. The developmental examination revealed mild mental retardation (I.Q.=50), disturbances in gross and fine motor development and speech disorders. The child was treated by developmental therapy which improved his abilities for a better social adjustment.
Child↗
Thrombopoietic activity in preterm newborns and infants.
Platelet count and thrombopoietic activity were investigated in preterm infants at birth and during their first four months of life. Thrombopoiesis stimulating factor activity in cord serum was significantly lower than that of adults and of the respective mothers. No difference was noted between thrombopoietic activity in cord serum in the various gestational ages studied--that is, 24 through 39 weeks. Preterm infants followed during their first four months of life showed a mean platelet count significantly higher than that observed in term infants at the respective age. Furthermore, thrombocytosis was found in premature thriving infants at the age of 1 and 2 months. It is suggested that this thrombocytosis is responsible for the low thrombopoietic activity observed in these infants during their first four months of life.
Adult↗
Thrombopoietic activity in newborn infants.
Platelet count and thrombopoietic activity were investigated in newborns and in infants during their first 4 months of life. Four-day-old newborns, although not thrombocytopenic, showed a significantly reduced platelet count as compared to that of control adults. Furthermore, a significantly lower thrombopoietic activity was found in the sera of newborns compared to that in the sera of adults. In addition, the thrombopoiesis-stimulating factor (TSF) activity in cord serum was significantly lower than that in the mothers' sera. Since 7 of 37 newborns examined in the present study showed a very low TSF activity, lower than that found in the saline controls, the possibility that an inhibitor for thrombopoiesis exists in the newborns is suggested and discussed. The follow-up study revealed a low TSF activity in the sera of 1-month-old infants followed by a gradually increased activity, reaching in the 4th month levels similar to those of adults. Concomitantly with the rise in TSF activity in the serum, an increased platelet count was observed.
Blood Platelets↗
Bart's syndrome: a mechanobullous disease of the newborn. Report of five cases and review.
Bart's syndrome is one among the lesser known presentations of epidermolysis bullosa. It is characterized by congenital localized bullae of skin and mucous membranes sometimes associated with nail deformities, all of which disappear during the neonatal period. Early recognition allows for avoidance of inappropriate systemic or local therapy.
Diagnosis, Differential↗
Congenital anterior urethral diverticulum associated with bilateral urinomas and dysplastic kidneys.
Congenital anterior urethral diverticulum (AUD) is a rare condition. We report a case of AUD associated with urinary ascites, bilateral urinomas and dysplastic kidneys. The diagnosis of urethral obstruction was established in utero by means of ultrasound. The right perirenal urinoma appeared "septated", and we believe that this is related to its hemorrhagic content. Improvement of the clinical condition and renal function was noted after decompression by bilateral cutaneous loop ureterostomy.
Diverticulum↗