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Biomedical subjects

L Simon

Publications and source records attributed to L Simon.

450 records · Page 25Linked to original sources
PubMedDate not supplied

[The hyperostotic foot].

Clinical and radiological examination of the foot in 25 cases of ankylosing verteral hyperostosis revealed signs of the disease in 16 cases: eleven patients had painful symptoms (predominantly pain in the heel, 9 cases) and and five had radiological changes in the feet which led to the discovery of the characteristic vertebral involvement. As for other extra-vertebral sites of vertebral hyperostosis, the foot warrants careful examination. The radiological lesions consist of osteophytic proliferations of the calcaneum (sometimes pathognomonic), scattered ossifications in the ligaments of the inferior and posterior aspects of this bone, the neck of the talus, the dorsum of the mid-foot, the internal aspect of the tarsal scaphoid or the external face of the styloid apophysis of the 5th metatarsal, and a bony proliferation enlarging the base of the distal phalanx of the big toe.

Aged↗
PubMedDate not supplied

[Sesamoid pathology of the 1st metatarsal bone].

The sesamoid region constitutes an "anatomo-clinical entity" because the small sesamoid bones and the tendino-sero-cutaneous formations which surround them are in close association. Subjected to various microtraumatisms, (professional, sports or static), it expresses its pathology through a painful sesamoid point, a localized tumefaction that is more or less ifnlammatory (sometimes with a pseudo-gout aspect) or a painful corn that disturbs walking. The observation of radiologic alterations of the sesamoid bones results in the discussion of osteonecrosis (Renander's disease) or a fracture. This region may also be the site of a specific micro-cristalline inflammation (with deposit of various crystals) or a rheumatic (mainly rheumatoid, sometimes psioriatic or spondylarthritic) responsible for sesamoid alterations of variable intensity. I can also be involved in an infectious process that is either acute or chronic (fistulization). The sesamoid region has a rich pathology, that is often poorly understood since it is inadequately investigated.

Adolescent↗
PubMedDate not supplied

A set-up for bronchial provocation by continuously generated aerosols.

Bronchial provocation tests have become a standard procedure to establish the diagnosis of asthma when symptoms are current but spirometry is normal. A simple, reproducible and widely used method for measuring airway responsiveness is continuous aerosol generation and tidal breathing inhalation. This paper presents the method, the apparatus built-up in our lung function office, reproducibility of aerosol production, and expression of results. With our set-up we are able to perform technically well regulated challenge. It has the advantages of relative simplicity in terms of equipment needed, short distance and no obstacles between nebulizer and mouthpiece. Our specially conceived computer programme is easy to handle, allows comparison and recalculation of data. Variations of nebulizers' output needs a carefully individual evaluation before use to allow reproducibility.

Aerosols↗
PubMedDate not supplied

Increased prevalence of soft tissue hand lesions in type 1 and type 2 diabetes mellitus: various entities and associated significance.

Sixty Type 1 (insulin dependent) and sixty Type 2 (non insulin dependent) diabetic patients attending a diabetology unit were examined in search of limited joint mobility, Dupuytren's disease, flexor tenosynovitis and carpal tunnel syndrome, in comparison with two populations of 60 non diabetic controls matched for sex and age with the Type 1 and the Type 2 diabetic patients. Microangiopathic and neuropathic complications, glycaemic control, blood pressure and tobacco consumption were simultaneously assessed in 39 of the 60 type 1 and in all the type 2 diabetic patients. The prevalence of the various soft tissue hand lesions was higher in both diabetic populations (respectively Type 1 and Type 2) than in their control populations: Limited joint mobility: 33.3 and 26.7% vs 5.0 and 8.3% (both p < 0.01); Dupuytren's disease: 35.0 and 30.0% vs 6.7 and 10.0% (both p < 0.01); flexor tenosynovitis: 23.3 and 16.7% vs 0.0 and 3.3% (p < 0.01 and p < 0.05); carpal tunnel syndrome: 26.7 and 15.0% vs 3.3 and 5% (p < 0.01 and NS). The prevalence of limited joint mobility in Type 1 diabetes was independently associated with increasing age (p < 0.05) and to lower extent with increasing duration of diabetes (p = 0.05), whereas the prevalence of Dupuytren's disease only correlated with increasing age in both types of diabetes (p < 0.05). In Type 2 diabetes, the prevalence of flexor tenosynovitis also increased independently with age (p < 0.05), and the prevalence of limited joint mobility increased in the opposite way to the body mass index after adjustment on age, duration of diabetes and sex (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

[Thyroid actinomycosis (actinobacteriosis)].

An extremely rare case (the 15th case reported in the literature, according to our knowledge) of the infection with Actinomyces Israeli localized at the level of thyroid gland is presented. Although the clinical and imaging data, the fine needle aspiration biopsy, and the intraoperative aspect clearly suggested the diagnosis of thyroid cancer, the microscopic examination surprisingly identified "sulfur granules", specific to actinomycosis, so that treatment and prognosis were reconsidered.

Actinomycosis↗