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Biomedical subjects

L Semino

Publications and source records attributed to L Semino.

8 recordsLinked to original sources
PubMed1975

[Evaluation of the reliability of the Heremans serum protein index in the differential diagnosis of jaundice].

Heremans' serum proteins index was evaluated in the diagnosis of 58 cases of icterus. Analysis of variance was employed in assessing the behaviour of the index in various forms of the disease. Its reliability was evaluated in the light of its sensitivity, specificity, suspicion, positivity, confirmation, validity and accuracy indices, information content and entropy. Multivariance analysis was also used to determine the mean and optimal values for the discriminating functions of neoplastic and non-neoplastic icterus forms.

Blood Proteins↗
PubMedDate not supplied

Deficiency of INFgamma producing cells in adenoids of children exposed to passive smoke.

Exposure to passive smoke is a very common event associated with increased susceptibility to respiratory tract infections. Many related adverse effects result from the ability of cigarette smoke extracts to interfere with the immune system, but the mechanism is not yet completely understood. The aim of the present study is to evaluate the intracellular cytokine profile in adenoids and peripheral blood cells of children exposed to passive smoke. Children undergoing adenoidectomy exposed or not exposed to passive smoke were studied. The intracellular cytokine profile of lymphocyte subsets in adenoids and in peripheral blood were evaluated by flow cytometry analysis. Children exposed to tobacco smoke showed a significantly lower percentage of INF-gamma producing CD4+ and CD8+ cells in adenoids. Moreover a significant correlation was observed between the quantity of exposure and reduction in Th1 (CD4+INFgamma+ and CD8+INFgamma+) cells in adenoids. This reduction may be a contributing factor in the increasing susceptibility to respiratory tract infection in children exposed to tobacco smoke.

Adenoids↗