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Biomedical subjects

L Selvaggi

Publications and source records attributed to L Selvaggi.

At least 145 records · Page 8Linked to original sources
PubMed1982

[Fetal glucose regulation: glycosylated hemoglobin in cord blood].

Glycosylated haemoglobins were assayed at delivery in 64 pregnant women (48 normals and 16 diabetics) in maternal and cord blood with the colorimetric method of Fluckigër and Winter-halter. A good correlation was observed between maternal and funicular glycosylated Hb (r = 0.67, p less than 0.001) in normal subjects; there wasn't any significant correlation in diabetic pregnant; (r = 0.29). Maternal glycosylated haemoglobins were compared to Schlichkrull's M of glycemic cycles in diabetic pregnant all these subjects showed a good glycemic regulation. Colorimetric technique can separate glycosylated haemoglobins from Hb F, and so allows their detection in cord blood. Glycosylated haemoglobin's assay in cord blood at delivery is an index of fetal glycoregulation in the last trimester of pregnancy and it represents a parameter of fetal pancreatic insulin incretion during intrauterine growth.

Blood Glucose↗
PubMed1982

Perinatal mortality and risk of delivery. What's happening in Italy?

The aim of this paper is to establish the exact incidence of risk in delivery as related to perinatal mortality rate. The entire 1976 Italian population was statistically sampled (latest data available), specifically enucleating the sanitary data reported in 1976 by ISTAT (National Institute of Statistics) for the various regions of Italy. Furthermore, the importance of preventive Medicine in reducing the rate of perinatal mortality is discussed. Our results showed that 29.2%, of total perinatal mortalities is connected to delivery. Yet in Southern Italy and on the islands (geographical districts with the highest perinatal mortality date reported) perinatal mortality was not principally due to delivery, showing that delivery is only one aspect of the complex problem of perinatal mortality, which is thus obviously not dependent on socio-economical and territorial factors. As other studies (I p. 131) report that the types of delivery procedures adoperated during that period (1976) were relatively homogeneous throughout Italy, we may conclude that the high perinatal mortality rate in Southern Italy is due to pathology regarding the pregnancy and not to the risk in delivery itself. (This is probably true even for other countries). For example, toxemia could very likely be one of the main causes. Therefore, the real incidence of toxemia together with the actual way of monitoring labor, etc. should be re-evaluated and considered in relation to the whole perinatal mortality. With this study, we obtained the following conclusions. Thus, from the point of view of preventive perinatal medicine, it could be more efficient to apply public health preventive actions during pregnancy than monitoring during labor.

Female↗
PubMed1982

Behaviour of immune complexes and the complement system in normal pregnancy and pre-eclampsia.

A quantitative study of the circulating immune complexes (IC) was carried out on women during normal pregnancy (286) and the post-partum period (20) and women with pre-eclampsia (30). Furthermore, the behaviour of the complement (C) system was followed. Results showed that IC were low in the first trimester of normal pregnancy (25.3%) and decreased in the following trimesters, whereas they were always present in pre-eclampsia. A very significant difference (p less than 0.0001) was seen when we compared the incidence of IC in normal pregnancy at the third trimester and the pre-eclamptic patients. The follow-up study of the IC, carried out on 4 pre-eclamptic women, showed an increase in the IC levels associated with the exacerbation of the pre-eclamptic picture and a decrease after delivery. The study of complement in normal pregnancy showed a decrease in C1-INH, C1s and C1q, whereas C3, C5, C9 and the properdin factor B increased during the following weeks of gestation; CH50 did not vary excepting during the 1st trimester. In the puerperium all values increased. There was no significant difference between the serum levels of the C components in the 3rd trimester of normal pregnancy and pre-eclampsia. High levels of C3d were observed in normal pregnancy at the 3rd trimester and in pre-eclampsia. The study of this split product of C3 showed that there is activation of the C system, but, since the synthesis of the C components is increased, activation could be masked. Alloantibodies and circulating IC could be the factors responsible for this activation in normal pregnancy and in pre-eclampsia, respectively.

Adult↗
PubMed1982

Evaluation and comparison of hemocoagulation parameters both in serum and in ascites from patients with gynecologic malignancies.

The authors report the results obtained investigating PT - PTT - Fbg - Alcohol test - FDP - AT III in the serum and FDP in the ascitic fluid of 18 patients with ovarian cancer, 2 patients with pelvic relapse of cervical cancer and 10 patients with cirrhosis of the liver. It is pointed out the presence of FDP in the ascitic fluid in large amounts, so it not seems to be an ovarian cancer specific marker, but an aspecific marker of malignancy.

Ascitic Fluid↗
PubMed1981

[The prune-belly syndrome. Antenatal diagnosis (author's transl)].

The authors describe an unusual case of the Prune-Belly Syndrome which was diagnosed antenatally using ultra-sound. They note at the same time that the urinary tract dilated very rapidly in the last weeks of pregnancy and that it was pointless to empty the fetal bladder repeatedly.

Adult↗
PubMed1981

Multiple malignant tumors of the uterus.

A case of a 59 year old patient with a diagnosis of uterine double carcinoma, namely of the cervix and of the corpus is reported. Pathological criteria of diagnosis and pathogenetic hypotheses are then discussed.

Adenocarcinoma↗
PubMed1979

[Action of complement in normal pregnancy and gestosis].

Behaviour of the complement system was studied in normal pregnancy, puerperium and in pre-eclampsia. CH50 showed no variations during normal pregnancy, excepting for first trimester, whereas it increased in puerperium. CVFAH50 increased steadily during all trimesters. C1q, C1s and C1-INH progressively decreased, while C3, C5, C9 and C3PA augmented. All values were clearly raised in puerperium. The decreased values of the early classical pathway components could be attributed to "blocking factors" (antibodies or immune-complexes) which could interfere with cellular immunity at fetoplacental level. The other components probably increase because there is a hormone-stimulated raised synthesis and a high turnover. The data obtained from pre-eclampsia did not reveal significant variations as compared to normal third trimester pregnancy, excepting for CVFAH50 which was reduced. This, however, does not exclude the possibility that there is an immunological pathogenesis of the pre-eclampsia, since activation of the C system is not always detectable in circulation.

Adult↗