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Biomedical subjects

L Scott

Publications and source records attributed to L Scott.

At least 73 records · Page 4Linked to original sources
PubMed1997

Iowa relaxes CON.

Explore the source record for details and available documents.

Capital Expenditures↗
PubMed1997

System growth a close race. 1997 multi-unit providers survey finds not-for-profits ahead by a nose.

For the first time in five years, the biggest dealmakers in 1996 were not-for-profit systems, not their giant for-profit brethren. But it was a close race, according to this year's Multi-unit Providers Survey. Based on total hospitals, not-for-profits grew 12% vs 11.3% at for-profits. In the psychiatric sector, the number of facilities rose 17%, but the number of deals tumbled 26%. And in the post-acute sector, outpatient and rehab services led the way.

Catholicism↗
PubMed1997

Communities strike back. Residents oppose ceding control to outside not-for-profit chains.

"We want our hospital back!" is the rallying cry in more communities as they fight outsider not-for-profit healthcare systems for control of their local hospitals. To date, most of the policy debate has centered on acquisitions of community hospitals by for-profit chains. But the rapid development of regional systems, which merge a number of once-independent hospitals, means even more bitter clashes lie ahead involving deals with the not-for-profit sector.

Community Participation↗
PubMed1997

Can marriage of academic, community hospitals work?

Can marriage of academic and community hospitals work? Executives at Fairview Health System in Minnesota believe it can--they have begun merging their system with University of Minnesota Hospital and Clinic, which Fairview purchased in January. But they admit the consolidation of two very diverse cultures will pose some intimidating challenges. If they succeed, Fairview's CEO says, "the potential is incredible."

Governing Board↗
PubMed1997

Outlook 1997. Batten down the hatches. Execs need to prepare for scrutiny of deals by citizens, regulators and the media.

Our reporters make their prognostications for a dozen major segments of the healthcare industry in 1997. A common thread runs through them: as mergers and consolidations continue to sweet through the industry, communities and regulators are becoming increasingly concerned about whether the public interest is being served. And, our reporters say, scrutiny of such deals is going to get even more intense.

Computer Communication Networks↗
PubMed1997

Local resection and brachytherapy confined to the lumpectomy site for early breast cancer: a pilot study.

BACKGROUND AND OBJECTIVES: The commonest site of local breast recurrence after breast conservation surgery is the primary tumor bed. We have tested the feasibility of outpatient high dose rate brachytherapy to the primary tumor bed as the only radiation. Our technique relies on the placement of surgical clips to mark the tumor bed. METHODS: Between March 1992 and January 1996, 39 patients with clinical T1 T2 breast cancer were enrolled in this pilot study. The first 13 patients had intraoperative implantation of the breast. The remaining 26 patients had outpatient postoperative implantation under general anesthesia (2 patients) or local anaesthesia (24 patients). High dose rate brachytherapy was given twice daily at least 6 hours apart for a total dose of 37.2 Gy in 10 fractions over 5-7 days. RESULTS: Three patients had mild clinical cellulitis responding to oral antibiotics. One patient had a small sinus in the lumpectomy scar requiring local excision to heal. Four patients developed fat necrosis at the lumpectomy site at 4 (1 patient), 13 (1 patient), and 18 months (2 patients) post radiotherapy. Patient rated satisfaction with treatment was high. At a median followup of 20 months, one infield local recurrence has been salvaged by wider resection and postoperative conventional external beam radiation. CONCLUSIONS: Except for fat necrosis, which may be associated with this technique, complications have been minimal. Outpatient implantation under local anesthesia is feasible. Longer followup is required to establish the local control rates.

Adult↗
PubMed1997

Intracortical inhibition of lower limb motor-evoked potentials after paired transcranial magnetic stimulation.

The aim of the present study was to determine the characteristics of intracortical inhibition in the motor cortex areas representing lower limb muscles using paired transcranial magnetic (TMS) and transcranial electrical stimulation (TES) in healthy subjects. In the first paradigm (n=8), paired magnetic stimuli were delivered through a double cone coil and motor evoked potentials (MEPs) were recorded from quadriceps (Q) and tibialis anterior (TA) muscles during relaxation. The conditioning stimulus strength was 5% of the maximum stimulator output below the threshold MEP evoked during weak voluntary contraction of TA (33+/-5%). The test stimulus (67+/-2%) was 10% of the stimulator output above the MEP threshold in the relaxed TA. Interstimulus intervals (ISIs) from 1-15 ms were examined. Conditioned TA MEPs were significantly suppressed (P<0.01) at ISIs of less than 5 ms (relative amplitude from 20-50% of the control). TA MEPs tended to be only slightly facilitated at 9-ms and 10-ms ISIs. The degree of MEP suppression was not different between right and left TA muscles despite the significant difference in size of the control responses (P<0.001). Also, conditioned MEPs were not significantly different between Q and TA. The time course of TA MEP suppression, using electrical test stimuli, was similar to that found using TMS. In the second paradigm (n=2), the suppression of TA MEPs at 2, 3, and 4 ms ISIs was examined at three conditioning intensities with the test stimulation kept constant. For the pooled 2- to 4-ms ISI data, relative amplitudes were 34+/-6%, 61+/-5%, and 98+/-9% for conditioning intensities of 0.95, 0.90, and 0.85x active threshold, respectively (P<0.01). In conclusion, the suppression of lower limb MEPs following paired TMS showed similar characteristics to the intracortical inhibition previously described for the hand motor area.

Adult↗
PubMed1997

Mouse in vitro fertilization, embryo development and viability, and human sperm motility in substances used for human sperm preparation for assisted reproduction.

OBJECTIVE: To investigate the endotoxin content and effects on mouse IVF and embryo development and human sperm motility of human sperm separation substances. DESIGN: One-cell and zona-free two-cell mouse embryo bioassays and Limulus Amoebocyte Lysate endotoxin tests and mouse oocyte parthenogenetic activation, IVF, preimplantation and postimplantation embryo development, and human sperm motility were performed in control medium or medium containing Percoll, Nicodenz, or the washings from Sperm Prep sephadex columns. SETTING: Research Laboratories, Sinai Hospital of Baltimore, Baltimore, Maryland. MAIN OUTCOME MEASURE(S): Endotoxin levels, embryo development, and sperm motility. RESULT(S): Mouse embryo bioassays indicated negative endotoxin levels in Percoll and Nicodenz but Limulus Amoebocyte Lysate assays had positive gel formation. Mouse IVF and preimplantation development was equivalent in control and Percoll- and Nicodenz-containing medium; none had parthenogenetic properties but postimplantation development was reduced for embryos grown in the presence of Percoll or Nicodenz. Human sperm remained motile in the presence of Percoll or Nicodenz. Sperm Prep column washes were toxic to mouse gametes and embryos and human sperm and had gel formation with the Limulus Amoebocyte Lysate assay. CONCLUSION(S): Percoll and Nicodenz, but not Sperm Prep sephadex column washes, were compatible with mouse preimplantation and postimplantation embryo development and human sperm motility.

Animals↗