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Biomedical subjects

L Schweiberer

Publications and source records attributed to L Schweiberer.

At least 217 records · Page 12Linked to original sources
PubMed1986

[Osteoid induction].

Osteoinduction is a biological principle. The implantation of tissue with inductive properties results in the proliferation and differentiation of undifferentiated cells to cartilage and bone. This process, which is similar to a cascade-type mechanism, is controlled by a series of humoral and local growth factors. It was possible to isolate a number of macromolecular substances with osteoinductive, mitogenic, or chemotactic properties specifically from the extracellular bone matrix. A deeper understanding of the regulative mechanisms as well as the greater availability of growth factors may lead to new therapeutic approaches in bone surgery.

Animals↗
PubMed1986

The effects of reaming and intramedullary nailing on fracture healing.

Most closed fractures of the shaft of the femur and tibia can be treated successfully with internal fixation with medullary or interlocking nails. Unlike plate fixation, intramedullary nailing does not provide absolutely rigid fixation, so that some motion at the fracture site exists. The process of reaming causes circulatory disturbances in the inner two-thirds of the diaphyseal cortex. However, this does not impede the formation of external callus. The parts of bone that have sustained vascular damage by trauma or surgery are revascularized. Delay in the healing process due to disruption of the blood supply to fracture fragments is not known. The majority of patients are able to weight-bear a few days after surgery.

Animals↗
PubMed1985

[Soft tissue and bone defects of the tibia. Treatment with pedicled muscle transfer and a microvascular anastomosed myocutaneous flap].

The free tissue transfer by microvascular anastomoses has opened new dimensions in reconstructive surgery. However a free microvascular myocutaneous flap should only be used in case of a local pedicled flap being impossible. In treating complicated defects of soft tissue and bones a clear cut gradation of therapeutic steps has to be observed: 1. control of wound infection, 2. wound debridement, 3. soft tissue repair, 4. bone reconstruction.

Adult↗
PubMed1985

[Anorectal malignant melanomas: report on 7 personal cases and 374 cases from the literature. Report of the experiences of a tumor center].

Seven cases of anorectal malignant melanoma are described and presented together with 374 cases reported on in the literature. The therapeutic procedure in stage I and II disease relies on radical surgery (abdominosacral rectum amputation), combined in cases of local metastasation with adjuvant chemoimmunotherapy using DTIC and BCG. In stage III disease therapeutic measures can achieve palliation only.

Adult↗
PubMed1984

[The problem of load stability in pathological fractures. Considerations on its indications using typical cases as examples].

Differentiated management of pathological fractures and multiple bone metastases is shown by means of 7 typical case examples. In the proximal femur, the total replacement of tumor-bearing bone areas by total hip prosthesis seems to provide the best stability. The femur shaft is stabilised without risk by intramedullary nailing, whereas metaphyseal stabilisation is best done by means of the interlocking nail. In the humerus, neutralisation plates are used, but they should be chosen long enough to anchor the implant in zones free fo tumour. The limitations of operability are demonstrated in one case. On the other hand, one case is shown where multiple metastases were treated palliatively by excochleation and filling the defect with bone cement, thus preserving the functional ability of the limb and the independence of the patient.

Aged↗
PubMed1984

[Restoration of an infected hip joint with sartorius-plasty].

For treatment of infected hip joints we use the proximally based sartorius muscle. After ligation of the vessels in the distal part of the muscle, the sartorius muscle is elevated and transposed to the floor of the deep joint cavity. By completely filling the space defect, reinfection of the osteomyelitic cavity is prevented. In addition, the transposed muscle flap directs optimal blood perfusion to the hypoxemic capsule tissue via its own vascular pedicle.

Aged↗
PubMed1984

[Infrared coagulation of the lung. Initial experimental and clinical results].

With regard to the good results which were found using the infrared coagulator (IRC) in hemostasis of liver and spleen experimental and clinical investigations of the lung were performed. Animal experiments elucidated the necessity of ligation of greater vessels as well as bronchi. Secure plugging of lung tissue was also possible following increased positive pressure respiration. A mean maximal extend of necrosis of 3 mm was measured. Clinical use in 11 patients proved secure plugging of tissue due to IRC application. Drainages could be removed within 4 days without appearance of broncho-pleural fistulas.

Adult↗