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Biomedical subjects

L Schnitzler

Publications and source records attributed to L Schnitzler.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Keratosis lichenoides chronica with mucous membrane involvement and ocular pseudo-pemphigus. Follow-up study over 18 years. Retinoid therapy (author's transl)].

A very uncommon ocular and mucocutaneous syndrome is reported. Cutaneous manifestations include keratotic plugs occasionally disposed into verrucous plaques (in mountainous chain), lichenoid lesions on face, neck and hand's back, and nail's involvement. Histologically three types of lesions are observed: marked hyperkeratosis, lichenoid aspect, and follicular pustulosis. Mucous membranes alterations, present for almost as long as 20 years, include stomatitis, chronic balanitis with ulcerative and keratotic lesions leading to synechiae; ocular abnormalities has had a follow up into lesions similar to those of cicatricial pemphigoid; direct immunofluorescence study in the vicinity of a buccal erosion showed a complement deposit on basement membrane; immunofluorescence studies on involved and uninvolved skin, and indirect immunofluorescence were negative. Several diagnosis were considered, in first place an atypical Reiter's syndrome. A part the possibility of a new entity, the most attractive hypothesis is this of a keratosis lichenoides chronica with severe mucous cicatrical lesions. A large number of treatment had been inefficacious but a clear improvement of keratotic lesions was noted with oral retinoid therapy.

Chronic Disease↗
PubMed1980

[Lipoatrophia semi-circularis of the thigh].

Two typical cases of this apparently rare condition usually observed in women are reported. 22 cases have been published since the first observation in 1974. Lesions are made of semi circular band-like, isolated, atrophy of the subcutaneous fatty tissue, involving half the circumference of anterolateral part of the thigh. No other clinical or biological abnormalities are noticed. Four stages may be histological considered. Ultrastructural investigation performed in our cases confirms histological findings: in the first case adipocyte's abnormalities, fibrillogenesis, and sclerosis are noticed, in the second case (persistent lipoatrophia) rarefaction of collagen's fibers appears to be the most important feature. Etiology remains unclear, but repeated external traumas seem the most plausible explanation in several cases of the literature and in our cases: case no. 1, related to leaning on bath's border for washing, was regressive after trauma's suppression, while the second case was not regressive since the patient did not discontinue wearing the responsible girdle.

Adipose Tissue↗
PubMed1980

[Evaluation of oral retinoid preventive action on human cutaneous epitheliomas (author's transl)].

Beneficial effects of oral retinoids in prophylaxis of epithelial neoplasias have been demonstrated by experimental works. In this study oral retinoid (RO 10-9359) was used in human dermatosis with high frequency of cutaneous malignancies: xeroderma pigmentosum with or without malignant neoplasias, Mibelli's porokeratosis with multifocal malignant degeneration, basal cell naevus syndrome with basal cell carcinomas, familial epithelioma of Ferguson-Smith and actinic keratosis. This work started in december 1977. Visible epitheliomas have been treated before trial. Initial dose of retinoid was 1 mg/kg daily, decreased depending on individual tolerance. Results were appreciated by comparising number of epitheliomas observed in years preceding retinoid therapy and number of them appearing during treatment; in two familial cases (basal cell naevus syndrom in twins and xeroderma pigmentosum in two brothers) comparison was made between treated and untreated patients. First results are very promising: an excellent response on solar keratosis is noted; epitheliomas occurrence seems actually to be prevented or delayed by oral retinoid therapy. Of course more numerous cases, a longer time, periods without treatment are necessary to confirm these interesting first results. On the other hand drug is not with this dose active on already constituted carcinomas.

Adolescent↗
PubMed1979

[Ultrastructural study in four cases of cutaneous xanthomas in children (author's transl)].

Three cases are associated with a Reclinghausen disease. Histological findings show typical xanthoma. Electron microscopical study indicates: --numerous intracytoplasmic lipid inclusions of various type (droplets, crystals, concentric lamellar bodies, ceroid granules) in dermal cells (histiocytic foam cells, endothelial cells, Schwann cells, fibroblasts and most cells); --large intranuclear inclusions in some histiocytes containing few lipids droplets; these figures could be compared to a slice of "petrified wood"; their significance is as yet unknown (Liesegang rings?).

Cell Nucleus↗
PubMed1979

[Erythema gyratum repens (Gammel's syndrome)].

A case of erythema gyratum repens is reported in 78 year old woman. The particularly typical eruption, mainly affecting the trunk, was associated with a squamous cell carcinoma of the esophagus. The paraneoplastic dermatosis cleared after radiotherapy of the cancer.

Aged↗
PubMed1978

[Lupus erythematosus profundus: two cases with ultrastructural study].

Lupus erythematosus profundus (panniculitis) is an unusual clinical variant of lupus erythematosus in which the lesions occur in deeper corium and panniculus. The diagnosis usually causes difficulty. Both reported cases are similar and concern young men with subcutaneous nodules appearing on the face and leaving depressed areas. Histological examination reveals a marked infiltrate in the dermis especially around the skin appendages, reaching the deep dermis and the fat tissue; this infiltarte is composed mainly of lymphocytes and histiocytes. Some moderate epidermal changes are present: liquefaction degeneration of the basal cell layer, epidermal atrophy, thickening of basement membrane (P. A. S.). Direct immunofluorescence of the lesions showed, in one case IgG deposits at the dermo-epidermal junction. Ultrastructural findingd are similar in both cases and may be an important point of diagnosis for isolated forms: -- tubular structures "paramyxo-virus-like-inclusions" are present in dermal infiltrate, endothelial cells and sometimes in keratinocytes of the basal layer; -- the basal lamina has many folds and villous projections;-- vacuoles and concentric lamellar formations are observed inside keratinocytes. No clinical or immunological signs of systemic lupus were found. Antimalaric drugs clear up the nodules.

Adolescent↗