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Biomedical subjects

L Savini

Publications and source records attributed to L Savini.

27 records · Page 2Linked to original sources
PubMed1990

New quinoline derivatives: synthesis and evaluation for antiinflammatory and analgesic properties--Note I.

New 4-anilinoquinoline-3-carboxylic acids, N-[3-carboxyquinolyl (4)]anthranilic acids and their corresponding esters were synthetized by reacting 4-chloro-3-carbethoxyquinolines with substituted anilines and methyl anthranilate respectively. All the compounds were tested for antiinflammatory and analgesic activities. Some derivatives showed a significant antiinflammatory activity comparable to that of indomethacin.

Analgesics↗
PubMed1985

[Quinolylhydrazones with potential antimicrobial and antiparasitic activity].

Quinolinehydrazones prepared by condensation of hydrazinoquinolines with 1-phenyl-2,5-dimethyl-3-pyrrolcarboxaldehyde, 2-chloro-4-dimethylaminobenzaldehyde and 2,6-dichlorobenzaldehyde are described. All compounds were tested in vitro for antimicrobial activity, the results obtained are shown and discussed. The quinolinehydrazones of the 1-phenyl-2,5-dimethyl-3-pyrrolcarboxaldehyde were tested in vivo against Hymenolepis nana and Taenia taeniaeformis and proved inactive.

Aminoquinolines↗
PubMed1985

[Tridentate N-N-N chelating systems as potential antitumor agents].

Tridentate chelating agents, as potential antitumor agents, were prepared by condensing 2-quinolylhydrazines, 2-pyridylhydrazine and 2-benzothiazolylhydrazine with pyridine-2-aldehyde, 6-methylpyridine-2-aldehyde, 2-acetylpyridine and 2-benzoylpyridine. All compounds were tested against Lymphocytic leukemia P388. The active pyridine-2-aldehyde-4-methyl-2-quinolylhydrazone [1-(4'-methyl-2'-quinolyl)-3-(2'-pyridyl)-1,2-diaza-2-propene] (I d) was also tested against other experimental tumors and proved inactive.

Animals↗
PubMed1975

Anticestode quinolinehydrazones.

One hundred and seven 4-quinolinehydrazones were synthesized and tested in vivo against the tapeworm Hymenolepis nana. Twenty-five derivatives showed significant cestocidal activity; structure-activity correlations were performed using Free-Wilson methodology. Two compounds, 2,6-dimethyl-4-[(3-pyridinylmethylene)hydrazino]quinoline and 2,6-dimethyl-4-[2p][(6-methyl)pyridinylmethylene]hydrazino)quinoline, predicted to be maximally active, effected 100% reduction of H. nana in mice at 200 mg/kg, p.o.

Animals↗