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Biomedical subjects

L Sarli

Publications and source records attributed to L Sarli.

At least 91 records · Page 5Linked to original sources
PubMed1984

Influence of bile flow interruption on acute experimental pancreatitis.

The influence of bile flow interruption on the pathogenesis of acute pancreatitis has been evaluated in the rat. The pancreatitis was induced by Pfeffer's technique and the severity of the disease was assessed by a macroscopic examination of the pancreatic damage and the calculation of amylase-to-creatinine clearance ratio (ACCR) as well. The results showed that the bile reflux into the pancreas made the pancreatic lesions caused by stasis in the gland associated with hyperstimulation of exocrine secretion more severe. On the other hand the bile reflux had no influence when the pancreatitis was due to flowing back of duodenal contents into the pancreas (closed duodenal loop). It was concluded that the bile effect is probably consistent with a pressure mechanism. In addition the reliability of ACCR in the diagnosis of acute pancreatitis was confirmed, and the test was effective in detecting even milder pancreatic damages.

Acute Disease↗
PubMed1984

Cholelithiasis and colorectal cancer.

To assess whether the higher risk of colorectal cancer is related to cholelithiasis rather than to cholecystectomy, a retrospective epidemiologic study was carried out on 350 patients operated for colorectal cancer. The incidence of a previous cholecystectomy or concomitant cholelithiasis was shown to be significantly higher in colorectal cancer patients with respect to controls (relative risk: 1.48 and 1.99 respectively). The association in both cases was more frequent for colorectal cancer. These results permit to hypothesize that the association with colorectal cancer does not concern previous cholecystectomy but rather cholelithiasis which is contemporaneously present or responsible for cholecystectomy.

Cholecystectomy↗
PubMed1983

[Protective effect of ranitidine in acute experimental pancreatitis in the rat].

Acute experimental pancreatitis was induced in rats, with a polyethylene splint placed into the duodenum, by the closed duodenal loop technique. Ranitidine (20 mg . kg-1) or saline were administered intraperitoneally every 8 hrs, beginning 15 min prior to surgery. The degree of pancreatitis and the amylase to creatinine clearance ratio (ACCR) were evaluated in all the animals after sacrifice. Ranitidine-treated animals showed significant by reduced pancreatic damage and ACCR values in comparison with non-treated rats. These data confirm the efficacy of ranitidine as a preventive agent in the development of acute pancreatitis and suggest that controlled trials should be performed with this H2-antagonist in the human subyects with this disease.

Acute Disease↗
PubMed1983

Lipase clearance in experimental acute pancreatitis.

Renal clearance of lipase, expressed as a proportion of simultaneous creatinine clearances was evaluated in an experimental model of acute pancreatitis in the rat. The lipase creatinine clearance ratio resulted very low in normal and control animals, while in rats with acute pancreatitis it increased regularly, significantly and proportionally to the degree of pancreatic damage. These observations indicated that, in this experimental model, the increased lipase creatinine clearance ratio is a sensitive index of acute pancreatitis, providing a basis for using the test in clinical practice.

Acute Disease↗
PubMed1981

[Diagnostic problems in lymphomas of the gastrointestinal tract].

The experience of the Authors refers to 10 cases of gastrointestinal lymphomas which came to our observation for December 1975 to July 1980. Of the 10 cases observed, 7 had a primary representation of the disease, the other 3 showed a generalized ò lymphoma. In 6 patients the stomach was affected and the small intestines in 4. Total or subtotal gastrectomy was carried out in 6 patients, Ileal resections in 3 and right hemicolectomy in 1. There were no post-operative mortalities and after treatment 7 patients survived. The Authors emphasize the difficulty created by the lymphomas of the digestive tract, particularly the primary ones, in as far as an exact preoperative diagnosis is concerned.

Adolescent↗
PubMed1981

[Our experience in the treatment of nonneoplastic obstructive pathology of the common bile duct by papillosphincteroplasty (author's transl)].

Starting from a discussion of the controversial views on the indications and correct execution of papillosphincteroplasty (PSP), the Authors report their own experience with the procedure and their first-hand evaluation of its merits, based on a series of 77 patients treated by PSP over the last 3 years (out of a total of 650 patients treated surgically for nonneoplastic pathology of the biliary tract). Their followup to date (up to 3 years after surgery), based on clinical, biohumoral and radiological findings, shows that the long-term results were excellent in 85%, good in 13%, and poor in 2% of the cases.

Adult↗
PubMed1980

[Cimetidine after operations on Vater papilla (author's transl)].

The effectiveness of Cimetidine in preventing complications, like acute pancreatitis and hemorrhagic gastritis, after operations on Vater papilla (ISP) is studied. In patients treated with Cimetidine the volume of nasogastric secretion was smaller and diastasemia and diastasuria treated values returned to the normal range earlier than in non-treated patients. In the latter group a case of pancreatitis and one of post-operative hemorrhagic gastritis were found. The treated patients, instead, did not suffer these complications. It was concluded that Cimetidine after IPS is useful, because it complies with the request that determined its employ.

Adult↗
PubMed1980

[Biliary lithiasis in patients aged over 70 years: considerations on 125 operations].

An experience with 125 over 70 aged patients, undergone surgery for biliary lithiasis, is here reported. These operations represent 17 percent on the whole performed ones for non malignant biliary tract diseases in Institute of Surgical Pathology of the University of Parma. As the age gets elder, we can see a percent increase of complications of lithiasis, and particularly of acute cholecystitis, of common bile duct diseases and generally of emergencies. Mortality rate was 5,6%. After cholecystectomy for uncomplicated gallstones mortality rate was zero. After operations for complications of cholelithiasis it was 9.3% (6,8% in elective, 18,7% in emergent surgery). According to the Authors, these results suggest that surgical elective indications in the aged patients have to be extensive, in order to reduce the risk of worse and often unavoidable complications.

Acute Disease↗
PubMed1978

[Experimental study on hepatic encephalopathy: EEG and blood amino acid findings].

The AA. describe a method of gradual occlusion of the portal vein in the rat to induce a hepatic encephalopaty. This method allows to realise a condition of hepatic ischemia and a portal hypertensive state accompanied by spontaneous portal-systemic shunts. These two factors produce a hepatic encephalopaty like in cirrhotic state or in patients after portal systemic anastomosis. A part from similar behavior at the beginning of the encephalopaty it is possible to define two classes of animals: one showing a slow recovery and one showing a transient and slight improvement followed at the end by the death of the animal. The AA. found a definite correlation amoung the clinica, EEG's, serum aminoacids and biochemical data. Probably the different anatomical and phisiological aspects of the induced portal systemic shunts and the different ways of hepatic rivascularization may determine the two different evolutions of the animals.

Amino Acids↗
PubMedDate not supplied

DNA content in human colon cancer and non-neoplastic adjacent mucosa.

DNA content was determined by flow cytometry in a series of 51 paired fresh tissue samples of primary colorectal carcinomas and the respective non-neoplastic adjacent mucosa in order to assess the relationship between DNA ploidy and the most commonly used prognostic factors. Aneuploidy was observed in 70.6% of the tumors and more than one aneuploid peak was present in 3.9%. Aneuploid tumor frequency was higher in left (93.3%) and right colon (64.7%) cancers than in rectal carcinomas (60.0%), and multiple aneuploid clones were detected more frequently in men than in women and in patients with advanced disease (Dukes stage D). Non-neoplastic mucosa adjacent to aneuploid tumors showed aneuploidy in 4 out of 51 samples (7.8%). The mucosa adjacent to diploid cancers had only diploid characteristics. Ploidy did not correlate with histological abnormalities. These findings suggest that DNA content as determined by flow cytometry needs further study with adequate follow-up to evaluate possible correlations with relapse-free and overall survival. Furthermore the aneuploidy of non-neoplastic mucosa provides evidence for a field defect in mucosa adjacent to colorectal cancer and supports the concept that this alteration may be of influence on carcinogenesis.

Adenocarcinoma↗