Biomedical subjects
Publications and source records attributed to L Santamaria.
A case of female urethral leiomyoma is presented. Due to its site of origin, at the bladder neck, the clinical picture resembled that of male prostatic median lobe enlargement. TUR was performed successfully and the authors feel that this should be considered the procedure of choice for leiomyomas arising in the proximal female urethra.
In a study of 143 selected human stomachs, resected for different pathologic changes, specific criteria were adopted to define the features of early gastric cancer, carcinoma in situ, gastric dysplasia, and gastric maturation disorders. The results in general did not lead to agreement in diagnoses, except in cases of early carcinoma, intestinal metaplasia, adenomatous polyps, and maturation impairment. A theory concerning the morphogenesis of gastric cancer was proposed in accordance with the data presented. This theory takes into account all possibilities of differentiations and dedifferentiations of the gastric gland stem cell pathway, as was determined from data of experimental carcinogenesis.
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The numbers of Ap and Ad spermatogonia per unit section of the testis were calculated in autopsy specimens from young adults and elderly men without testicular pathology. The number of Ap spermatogonia decreased from the 6th decade of life, whereas that of Ad spermatogonia began to decrease in the 8th decade. Although it has been reported that Ad spermatogonia are more sensitive to noxious agents than Ap spermatogonia, the involution of Ap spermatogonia precedes that of Ad spermatogonia. These findings provide new information on concepts relating to the spermatogonia precedes that of Ad spermatogonia. These findings provide new information on concepts relating to the spermatogonial stem cell in man.
The occurrence of diverticula in human seminiferous tubules was investigated in the adult human testis in normal as well as physiologic (aging) and pathologic (germ cell depletion, obstruction of male excretory ducts, varicocele and systemic arteriosclerosis) conditions. Diverticula, which are evaginations of the seminiferous epithelium surrounded by a thin tunica propria, were present in all groups studied. The number of diverticula per mm2 testis was higher in the testis with obstruction than in those without obstruction at each age considered. The number of diverticula increased with age in both the obstructed and nonobstructed testis. No changes in the number of diverticula per mm2 testis were found in relation to systemic arteriosclerosis or different degrees of germ cell depletion. Varicocele was only associated with increased numbers of diverticula when it was also associated with obstruction. The formation of diverticula in human seminiferous tubules seems to be an obstructive process related to increasing age.
The number of mononucleate and multinucleate Leydig cells per unit area of the testis was determined in normal adult men using the peroxidase-anti-peroxidase method for testosterone detection. The results of this study indicate that the number of multinucleate Leydig cells increases markedly with age, whereas the total Leydig cell population decreases.