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Biomedical subjects

L S Zingerman

Publications and source records attributed to L S Zingerman.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Rate of development and the size of the necrotic focus in patients with myocardial infarct treated by intracoronary thrombolysis].

Streptokinase intracoronary thrombolytic therapy (ITT) was given to 68 of 135 patients with large-focal myocardial infarction (MI) admitted to hospital within 6 hours of the attack. Coronary flow was recovered in 31 MI patients. The size of the necrotic focus was assessed on the basis of precordial cartograms from 35 ECG leads and serial measurements of MB CPK activity. ITT achieving successful thrombolysis is conducive to rapid formation and accelerated repair of the necrotic focus in MI patients. The recovery of coronary circulation after 3 hours of infarction was accompanied by the reperfusion syndrome, i. e. rapid necrotization of the ischemized region, a considerable release of MB CPK into the circulation, complex cardiac rhythm and conductivity disorders, and signs of transient heart failure.

Adult↗
PubMed1984

[Diagnosis and phasic character of the course of the midbrain syndrome secondary to acute intracranial hematoma].

Thirty patients with acutely developed intracranial hematomas of traumatic and nontraumatic origin were subjected to a combined examination. In all cases, cerebral angiography was performed and evoked auditory trunk potentials were studied. Comparison of the resultant findings with the data from a clinical-neurologic and echoencephalographic examinations and also with pathomorphological evidence made it possible to identify new diagnostic criteria for determining an acute dislocation syndrome at the temporal-tentorial level, particularly for the purpose of detecting cerebral infiltrations.

Acute Disease↗
PubMed1984

[Changes in the hemostatic system and the progression of arteriosclerosis in ischemic heart disease patients].

The effect of standardized mental stress on the hemostatic system was studied in 160 patients with coronary heart disease. The diagnosis of coronary atherosclerosis was documented by selective coronary angiographic findings. Emotional tension was modelled using the method of counting with interswitching in conditions of time deficit, irritating light and sound signals, as well as critical remarks about the work performed. According to the protective-adaptive activation of the anti-clotting system, the patients were divided into two groups: 1 with activation of heparin activity of the blood and fibrinolysis, 2 with depressed fibrinolysis and lowered blood heparin. Prior to the onset of the study the patients of both groups exhibited hypercoagulation as compared with the control group. The maximum degree of hypercoagulation was observed in the second group patients. Hypercoagulative changes both at rest and under stress were shown to depend on the degree of coronary artery damage.

Adult↗
PubMed1984

[Relationship between serum lipid level and the state of the coronary arteries in young patients with ischemic heart disease].

Selective coronary angiography was performed and variations of blood serum lipid levels were studied over time in 45 myocardial infarction survivors under 40 years of age. The results showed that the development of myocardial infarction in young individuals is underlied by coronary atherosclerosis. Hyperlipidemia was elicited in a larger proportion of cases as compared to changes on coronary angiograms, since the latter record only marked alterations whereas the initial stage of the active atherosclerotic process is manifested in changed lipid and lipoprotein concentrations in the blood serum in the absence of any changes on coronary angiograms. Functional impairments of the coronary circulation were implicated in the genesis of myocardial infarction only in 17% of the patients.

Adult↗
PubMed1983

[Fibrinolytic therapy and mechanical restoration of patency of the coronary arteries in acute myocardial infarction].

Results of a Moscow--Berlin collaborative study of urgent coronarography in acute myocardial infarction, using intracoronary treatments (fibrinolytic agents and mechanical thrombus destruction), are reported. Urgent coronarography was performed in 58 patients. Coronary flow could be recovered or improved in 27 patients, as evidenced by control coronarographic tests, particularly late follow-up ones. The procedure did not prevent myocardial infarction, but alleviated its course.

Adult↗
PubMed1983

[Elevation of the ST segment during physical exertion: computer analysis, comparison with angiographic data; clinical significance].

A total of 41 male patients responding with ST elevation to treadmill exercise were investigated using coronaro- and ventriculography, and sector-scanning echocardiography. All the patients had a history of anterior myocardial infarction. Computer analysis of changes in ST interval showed ST incline and integral to be the most informative parameters. Angiographically, marked stenosis (75% and more of the lumen) of one coronary artery was established in 21, two arteries, in 10, and three arteries, in 2 patients; coronary arteries were intact in 1 case. It is suggested that resting ST elevation as recorded from the leads with QS complex is more commonly associated with left ventricular aneurysm. The location of exercise-related ST elevation correlates well with marked proximal stenosis of a corresponding coronary artery an is not dependent on the presence of left ventricular aneurysm or the number of affected arteries. In patients with a history of transmural anterior myocardial infarction, the elevation of ST interval in response to exercise is due to dyssynergy of the left ventricular wall, rather than myocardial ischemia.

Adult↗
PubMed1983

[ECG manifestations in severe involvement of the coronary arteries in patients with chronic ischemic heart disease].

Correlation of electrocardiographic and coronarographic findings in patients with severe chronic coronary heart disease and massive coronary arterial lesions has demonstrated a tendency to increasing proportion of clinically normal electrocardiograms as more arteries are drawn into the pathologic process. Relationships between ECG voltage and different variants of coronary arterial damage are reviewed: the involvement of the right and part (at least one branch) of the left coronary arteries corresponds to low-voltage ECG. The association between left-ventricular aneurysm and the number of affected coronary arteries is examined.

Adult↗
PubMed1980

[Collateral circulation syndromes in the brachiocephalic artery system].

In 56 patients qualitative and quantitative characteristics of variants of collateral circulation in the system of occluded brachiocephalic arteries were studied. The objects of the studies were angiographic and clinical appearance of the variants of retrograde blood flow and the latter's connection with cerebral circulation. It was shown that the reversion of the blood flow from the Willis circle system was observed in 25% of patients with occlusive affections of the brachiocephalic arteries. The most frequent was the flow through the spinal arteries. The subclavicular steal syndrome led to cerebral circulation disturbances that manifested mostly in the form of transitory disturbances of the circulation in the vertebrobasilar and less often the carotid basins of the cerebral circulation. The neurological disturbances were the most specific in patients with isolated affections of the brachiocephalic stem or the subclavicular arteries. At the same time the intensity of the retrograde flow from the Willis circle system is regulated by the level of cerebral circulation, and depends on the degree of the vasocerebral insufficiency.

Adolescent↗