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Biomedical subjects

L S Zhang

Publications and source records attributed to L S Zhang.

At least 37 records · Page 2Linked to original sources
PubMed1990

Influences of refined konjac meal on the levels of tissue lipids and the absorption of four minerals in rats.

This paper reports a study on the hypocholesterolemic effect of the refined konjac meal (RKM) containing about 80% glucomannan prepared from the tubers of Amorphophallus konjac K. Koch. Male and female Sprague-Dawley rats, 5 weeks old, were divided into five groups and fed a normal basal diet, a hypercholesterolemic diet (control diet), and three test diets (RKM added to the control diet at levels of 2.5, 5, and 10%, respectively) for 12 weeks. The results obtained indicate that RKM could markedly lower the cholesterol levels in the serum and the liver of rats eating hypercholesterolemic diets. At the end of the 4th week of feeding experiment, the serum cholesterol levels in the 5 and the 10% RKM groups and the liver cholesterol level in the 10% RKM group were significantly lower than those in the control groups. At the end of the 12th week, the serum cholesterol levels of all the three RKM groups were lowered to a normal level as was the liver cholesterol level of the 10% RKM group. The lipotropic effect of RKM was also confirmed by histopathologic examination of the livers. In addition to the hypocholesterolemic effects, RKM diets also increased stool bulk. Minor effects on the absorption and utilization of Ca, Fe, Zn, and Cu were found.

Animals↗
PubMed1988

The measurement of platelet aggregation and ATP-release in mice with liver damage induced by carbon tetrachloride (CCl4) using a whole blood aggregometer.

Time course change in platelet function on liver damaged mice was studied by a whole blood aggregometer. The liver damaged animals were produced by single and multiple injections (p.o.) of 20% CCl4 in olive oil to ddY mice (6 weeks). Platelet aggregation and ATP-release were induced with collagen (final conc. of 2 micrograms/ml), ADP (final conc. of 20 microM) and arachidonic acid (AA: final conc. of 100 microM). After a single injection of CCl4, platelet counts increased at 5 and 12 hr, and then they decreased from 24 to 120 hr. Multiple injections of CCl4 resulted in a significant increase in platelet counts. A single injection of CCl4 suppressed aggregation by collagen at 24 and 48 hr and diminished the rate of ATP-release from 12 to 48 hr. AA-induced platelet aggregation was depressed at 48 hr, and ATP-release was also diminished from 24 to 72 hr after a single injection. ADP-induced platelet aggregation was decreased 24 and 48 hr after a single injection and at 48 hr after multiple injections, while, the rate of ATP-release by ADP was significantly increased after single and multiple injections. These changes in platelet functions might be consistent with our original report on the alterations in coagulative and fibrinolytic activities with CCl4-induced liver injury.

Adenosine Diphosphate↗
PubMed1987

Correlation of dietary aflatoxin B1 levels with excretion of aflatoxin M1 in human urine.

Corn and peanut oil (total, 253 samples) were collected from 32 households in Fushui county of the Guangxi autonomous region of the People's Republic of China, where high liver cancer incidence has been reported, every day over a period of 1 week and analyzed for aflatoxin B1 (AFB). A total of 252 urine samples were collected simultaneously from the residents in the households which were shown to have consumed AFB and were analyzed for aflatoxin M1 (AFM) by a competitive direct enzyme-linked immunosorbent assay. A good correlation between total dietary AFB intake and total AFM excretion in human urine was observed during a 3-day study. A regression equation of 0.143 plus 0.0135 multiplied by the amount of AFB consumed was observed. Between 1.23 and 2.18% of dietary AFB was found to be present as AFM in human urine. A good correlation was also observed between the AFB concentration in corn and the AFM concentration in human urine. The results suggest that analysis of AFM in urine by enzyme-linked immunosorbent assay could be used as an index for human exposure of AFB in an extensive epidemiological study.

Aflatoxin B1↗
PubMed1987

[Effect and toxicity of entrapped polysiloxane 5-Fu polycondensate].

Entrapped 5-Fu polysiloxane polycondensate (DMS-Fu) and equivalent doses of 5-Fu were tested on S-180 mice. At the dose of 100 mg/kg, the inhibition potency of these two compounds on tumor was similar, but the inhibition on the body weight was more marked in 5-Fu treated mice. At the dose of 250 mg/kg, all mice treated with 5-Fu died of toxicity but the mice treated with DMS-Fu survived and showed no obvious toxic effect. At the dose of 150-200 mg/kg, the peripheral white blood cells and the bone marrow nucleated cells of 5-Fu treated mice were seriously reduced, which lasted for several days before recovery. In the DMS-Fu group, the inhibition was mild.

Animals↗