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L S Ross

Publications and source records attributed to L S Ross.

52 records · Page 3Linked to original sources
PubMed1982

A review of oral cancer screening and detection in the metropolitan Detroit cancer control program.

In summarizing the experience of the twenty-seven months of the oral cancer screening and detection program the data indicate: 1.) Cancers were detected at earlier stages than is reported nationally. Further investigation is needed to determine whether there is a correlation between early detection and increased survival. (Kaufman 1980). 2.) The detection of fifteen precancerous lesions is significant in that intervention may have precluded malignant transformation. 3.) Of those found with oral cancers, eight were symptomatic and two were asymptomatic, while in the premalignant group five were symptomatic and seven were asymptomatic. On the basis of these data, it appears that the symptomatic group chose the screening program as a pathway of entry into the medical system. The motivation for this choice requires investigation. Possible hypotheses are: screening by a registered dental hygienist and in a familiar setting was less threatening than by a physician or dentist in a formal medical setting. The reputation of the MCF, as a center of excellence in cancer control, may have contributed to the willingness to be screened. 4.) The incidental detection of five skin and three laryngeal cancers was an aid to cancer control. 5.) The program successfully trained and utilized registered dental hygienists in oral cancer screening thereby demonstrating an economical use of professional health resources. Follow-up is needed to ascertain whether their training is successfully applied in private practice. 6.) Efforts to reach the high risk population were less productive than expected because, while target screening sites serviced heavy drinkers and smokers, their populations were sometimes less than 40 years-of-age. This finding suggests a need for more refined strategies for accessing high risk populations.

Adult↗
PubMed1981

Routine hormonal screening of infertile men: is it worthwhile?

More than 800 men referred for infertility have been evaluated in a male infertility clinic. Routine hormonal screening of these patients has included at various times thyroid function studies, 24-hour urine samples for 17-ketosteroids and pregnanetriol, serum dehydroepiandrosterone-sulfate, serum 17-alpha-hydroxy progesterone, testosterone and prolactine in some instances. The results of this hormonal screening are analyzed and discussed from the point of view of positive diagnostic findings and success of treatment. An outline and recommendations for the routine use of such studies are made.

17-Ketosteroids↗
PubMed1980

Clomiphene treatment of the idiopathic hypofertile male: high-dose, alternate-day therapy.

Increasing reports suggest that clomiphene citrate (clomid) is useful in the treatment of idiopathic hypofertile males. Recent studies have advocated low-dose, cyclic therapy (25 mg daily for 25 days, 5 days' rest) and, although significant clinical responses have been reported, the hormone response has been erratic. This study of 53 patients, given high-dose, alternate-day therapy (100 mg three times/week), shows an over-all positive response rate of 66% and a pregnancy rate of 26%. Significant gonadotropin and testosterone surges were seen in the responders, but a selective lack of a follicle-stimulating hormone surge was noted in a small group of nonresponders. Clomiphene given in this dosage seems to be safe for periods of up to 15 months and appears to be a rational and useful agent for the treatment of this patient group.

Adrenal Cortex Hormones↗
PubMed1979

Effect of metabolic inhibitors on vasopressin-stimulated transport systems in the toad bladder.

Vasopressin increases the permeability of receptor cells to water and, in tissues such as toad bladder, to solutes such as urea. While cyclic AMP appears to play a major role in mediating the effects of vasopressin, there is evidence that activation of the water permeability system and the urea permeability system involves separate pathways. In the present study, we have shown that inhibitors of oxidative metabolism (rotenone, dinitrophenol, and methylene blue) selectively inhibit either vasopressin-stimulated water flow or vasopressin-stimulated urea transport. There was no inhibition, however, when exogenous cyclic AMP was substituted for vasopressin, and little to no inhibition when the potent analogue 8-bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) was employed. Rotenone had no effect on adenylate cyclase activity or cyclic AMP levels within the cell; dinitrophenol decreased adenylate cyclase activity minimally. Additional studies with vinblastine and nocodazole, inhibitors of microtubule assembly, demonstrated an inhibition of vasopressin and cyclic AMP-stimulated water flow but showed no effect on urea transport. We would conclude that water and urea transport, as examples of hormone-stimulated processes, have different links to cell metabolism, and that in addition to cyclic AMP, a non-nucleotide pathway may be involved in the action of vasopressin.

Adenylyl Cyclases↗
PubMed1979

What about the other kidney?

Sophisticated diagnostic techniques have made the isolation of renal lesions more accurate. However, it must be remembered that simultaneous bilateral kidney pathology can exist in any patient. The most obvious lesion may not be the most important. Four cases are presented to illustrate this point.

Aged↗
PubMed1977

Epidermoid cysts of testis: rationale for conservative management.

The literature on epidermoid cyst of the testis is reviewed, and 2 additional cases are presented. Etiology and pathology of the disease are discussed. Our review revealed that 85 per cent of patients have undergone orchiectomy for this benign disease. Diagnostic characteristics of this lesion are emphasized so that in selected cases enucleation of the pidermoid cyst may be considered without violating the principles of cancer surgery.

Adult↗