[Information in support of barring the use of tetracyclines and streptomycin as growth stimulants].
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Biomedical subjects
Publications and source records attributed to L S Priputina.
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Experiments on white male Wistar rats with the use of the cinetelevision technique have shown that armine in a single LD50 provokes a 85-100% increase in the blood flow rate in the microvessels and a 45-50% elevation of the diameter of the pial arterioles. Administration of the drug in a dose of 1/2 of the LD50 brings about a 90% increase in the blood flow rate, whereas the diameter of the arterioles declines by 25%. The LD50 of armine lowers the cholinesterase activity in the brain and blood by 50-60%, while 1/2 of the drug LD50 by 20-30%.
Introduction of kormogrisein-10 and fradizin-10 into feeds of farm animals did not lead to accumulation in the animals' meat of grisin and tilozin residues or to an adverse effect of such meat on the body of experimental rats. In the course of oral administration of the preparations to the animals the authors determined the period of detectability of antibiotic residues in muscles and organs and the minimal toxic doses of the preparations.
Investigations made it possible to establish that in the period from 1925-28 to 1970-71 there took place in the Ukraine an increase in the consumption of animal products (milk, meat, fish, eggs), of sugar, vegetables, fruits and a fall in the consumption of cereals (bakery products, grits, macaroni, beans) and potato. Because of these dietary changes in the nutritional pattern of the population there were noted an elevated proportional share of proteins and fats, basically of animal origin, and a decrease in that of complex carbohydrates. A direct relation between the health status of the population and its alimentation has been ascertained; first--between the calorific value of the food products sets and their fat and carbohydrates content, on the one hand, and the body weight of the examined, on the other; and secondly--between the fluorine level in the food and the prevalence of fluorosis, caries, exostosis, aggravated by an imbalance of a number of nutritional components, on the other. Note has been taken at the same time of the fact that obese individuals suffer more often from cardio-vascular affections, gout, uro- and cholelithiasis and diabetes mellitus.