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Biomedical subjects

L S Liu

Publications and source records attributed to L S Liu.

At least 73 records · Page 4Linked to original sources
PubMed1988

Urinary cations and blood pressure: a collaborative study of 16 districts in China.

Relationships between blood pressure and overnight urinary sodium, potassium and calcium were investigated in 3248 subjects from 16 districts in China. Average systolic (SBP) and diastolic (DBP) blood pressures of subjects from northern, middle and southern China were 116/74.2, 114/70.5 and 110.8/69.6 mmHg, respectively. Urinary sodium, potassium and calcium were 55.1, 8.3 and 1.1 mmol/l for the north, 63.6, 9.2 and 1.6 mmol/l for the middle and 50.0, 8.9 and 1.5 mmol/l for the south, respectively. The urinary sodium to potassium ratio was significantly and positively correlated with SBP and DBP in both males and females. Urinary sodium was weakly and positively correlated with SBP only in the north. Females over the age of 50 years were especially sensitive to sodium intake. Urinary calcium was negatively correlated with DBP in both males and females. Urinary calcium (creatinine) was negatively correlated with SBP in males, and with SBP and DBP in the south. Urinary potassium was negatively correlated with SBP and DBP only in the 20-29 year age group. Urinary potassium (creatinine) was negatively correlated with DBP only in the south. Age and body mass index were positively and level of education negatively correlated with blood pressure. Dietary factors for higher blood pressure in northern China were related to higher sodium, lower potassium and possibly lower calcium intake.

Blood Pressure↗
PubMed1987

Therapeutic actions of alpha-human atrial natriuretic polypeptide in 16 clinical cases.

Alpha-human atrial natriuretic polypeptide (alpha-hANP) was applied to 16 clinical patients, 6 patients with essential hypertension, 7 patients with congestive heart failure and 3 patients with cirrhosis. Following intravenous bolus injection of 400 micrograms of synthetic alpha-hANP, a hypotensive effect of very rapid onset was found, which was more potent in the hypertensive patients than in the normotensive cases. Cardiac functions were improved significantly with a similar time course as the depressor response in the cases of heart failure or hypertension. Hemodynamic observations showed a marked increase in cardiac output, cardiac index, stroke volume, ejection fraction and ejection rate, and a concomitant decrease of the pressure in the right side of the heart and pulmonary circulation in these subjects. In addition, the renal response to alpha-hANP induced obvious increases in urine volume, electrolytes and creatinine excretions in all the subjects. Finally, plasma levels of aldosterone, Arg-vasopressin and noradrenaline were also altered by alpha-hANP. No significant side effects were registered. The above result confirms the therapeutic actions of alpha-hANP in human subjects and opens the possibility to research alpha-hANP as a powerful pharmacological tool as well as potential new medicine for human disorders.

Adult↗
PubMed1987

Monitoring effects of alpha-human atrial natriuretic polypeptide (alpha-hANP) on left ventricular function in patients with essential hypertension with a cardiac probe.

The effects of alpha-hANP on left ventricular function were studied with a cardiac probe in ten patients with essential hypertension. Our data showed that intravenous administration of alpha-hANP significantly elevated left ventricular function. At 5 min, the elevation of EF, RCO, ER, RSV, PFR were 13.23% (P less than 0.02), 12.7 (P less than 0.02), 0.618 (P less than 0.02), 0.133 (P less than 0.05), 0.283 (P less than 0.01), respectively. At 10 min, the increase of EF, ER, were 11.07% (P less than 0.02) and 0.233 (P less than 0.01), respectively. Atriopeptin significantly reduced systolic and diastolic blood pressure from 2 min to 20 min (P less than 0.001-0.05).

Adult↗
PubMed1987

Cloning of genes developmentally regulated during plant embryogenesis.

Genes specifically induced during somatic embryogenesis may play key roles in plant embryo development. An antiserum against an extract of carrot somatic embryos revealed a few rare antigens induced at the onset of embryogenesis. Through differential immunoadsorption techniques, we purified antibodies against the embryo-specific antigens and probed a phage lambda gt11 library of cDNA from carrot somatic embryos. This paper describes three distinct cDNA clones that hybridize to embryo-specific RNAs. Monospecific antibodies, purified by affinity to the recombinant phage fusion proteins, confirm that the cloned cDNAs encode unique embryo-specific peptide antigens. One 50-kDa protein correlates with embryogenic ability in cultures of other plant species, including cereals.

Journal Article↗
PubMed1987

Variability of urinary sodium and potassium excretion in north Chinese men.

Variability of urine sodium (Na), potassium (K) and sodium/potassium (Na/K) excretion was studied in a sample of 50 employed normotensive male health professionals aged 27-50 in Beijing, China. Six 24-h urine specimens were collected from each participant during night-time (12-h) and daytime (12-h) fractions. The estimated ratio of intra- to inter-individual variances was 2.12 for night-time and 1.48 for 24-h urine Na, and 1.85 and 1.54, respectively, for urine K. Based on these values, six night-time and four 24-h urine specimens are necessary to reduce to 15% the diminution of a correlation between urine Na and another physiological variable. The corresponding numbers are five and four, respectively, for urinary K measurement. These data suggest that the ratio of within-person variation to between-person variation in Na excretion is smaller in these Chinese men than in Americans. The dietary Na intake of Chinese men can therefore be characterized with fewer urine specimens than are required for western populations. Night-time urinary Na and K showed good concordance with those from 24-h specimens in distinguishing high or low Na and K intake. These findings indicate that in large-scale epidemiological studies, overnight specimens may be adequate for classifying individuals with regard to Na and K intake.

Adult↗
PubMed1986

Relationship between salt excretion and blood pressure in various regions of China: Part 2.

Overnight urine samples were collected on three consecutive days from 2483 persons in 12 regions of China and the mean 9-hour overnight sodium and potassium levels subsequently determined. Analysis of the data by univariate regression, simple correlation, and multiple regression indicated that there was a positive correlation between the mean level of sodium in urine and blood pressure.

Adult↗