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Biomedical subjects

L S Harris

Publications and source records attributed to L S Harris.

At least 181 records · Page 10Linked to original sources
PubMed1973

Tolerance to the hypothermic effects of 9-tetrahydrocannabinol as a function of age in the chicken.

1. (-)-Delta(9)-Tetrahydrocannabinol was administered to chicks (Gallus domesticus) of various ages and body temperature and tolerance to the hypothermic effects of the drug were examined as a function of age.2. The hypothermic effects were found to be greater in neonatal than older animals and likewise tolerance took longer to develop in younger chicks.3. The rate of tolerance development, however, could be increased in the neonate by preadministration of a high dose of the drug.

Aging↗
PubMed1972

Water-soluble derivatives of 1 -tetrahydrocannabinol.

Delta1-Tetrahydrocannabinol, which is resinous and insoluble in water and therefore difficult to study pharmacologically, can be converted to a watersoluble derivative without loss of its biological activity. This has been achieved by preparing esters bearing a nitrogen moiety with the use of carbodiimide as the condensing agent. The availability of such water-soluble derivatives will allow the evaluation of Delta1-tetrahydrocannabinol in self-administration studies in monkeys for its addiction liability potential in man. This technique of water solubilization is also applicable to other compounds of chemical and biological significance.

Amphetamine↗