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Biomedical subjects

L S Halstead

Publications and source records attributed to L S Halstead.

At least 19 recordsLinked to original sources

The John Stanley Coulter lecture. The power of compassion and caring in rehabilitation healing.

Rehabilitation of persons with catastrophic illnesses or injuries is a complex, labor-intensive interaction between patients and caregivers. Experiences of overwhelming loss and suffering evoke strong emotions that shape the behavior of both patients and staff during the rehabilitation process. In response to each patient's unique experience, compassion, caring, and other humanistic qualities of the effective caregiver help create a healing environment. Although these qualities are universally accepted as important, they have not been widely studied or critically examined. In recent years, however, there has been a growing interest in use of scientific methods to investigate the impact of "humanistic elements" (ie, complementary and alternative medicine) as therapeutic agents. A review of 7 articles from this literature provides examples of research-based interventions with potential for enhancing outcomes in traditional rehabilitation populations. In today's high-tech impersonal health care system, the use of scientific methods to show that humanistic treatments are effective may represent an important new frontier and opportunity for rehabilitation research.

Complementary Therapies↗

National rehabilitation hospital limb classification for exercise, research, and clinical trials in post-polio patients.

A need exists for an objective classification of polio patients for clinical and research purposes that takes into account the focal, asymmetric, and frequent subclinical nature of polio lesions. In order to prescribe a safe, effective exercise program, we developed a five-level (Classes I-V) limb-specific classification system based on remote and recent history, physical examination, and a four-extremity electrodiagnostic study (EMG/NCS). Class I limbs have no history of remote or recent weakness, normal strength, and a normal EMG. Class II limbs have no history of remote or recent weakness (or if remote history of weakness, full recovery occurred), normal strength and EMG evidence of prior anterior horn cell disease (AHCD). Class III limbs have a history of remote weakness with variable recovery, no new weakness, decreased strength, and EMG evidence of prior AHCD. Class IV limbs have a history of remote weakness with variable recovery, new clinical weakness, decreased strength, and EMG evidence of AHCD. Class V limbs have a history of severe weakness with little-to-no recovery, severely decreased strength and atrophy, and few-to-no motor units on EMG. In a prospective study of 400 limbs in 100 consecutive post-polio patients attending our clinic, 94 (23%) limbs were Class I, 88 (22%) were Class II, 95 (24%) were Class III, 75 (19%) were Class IV, and 48 (12%) were Class V. Guidelines for the use of this classification in a clinical/research setting are presented along with sample case histories and class-specific exercise recommendations.

Adult↗

Relief of spasticity in SCI men and women using rectal probe electrostimulation.

Although there are numerous approaches to the treatment of spasticity, many patients are still unable to find a satisfactory method of managing their spasms with acceptable side effects. In the course of our fertility studies using rectal probe electrostimulation (RPES) in SCI men to produce ejaculation, we observed that a majority of the men experienced significant relief of their spasticity for many hours. This report describes a prospective, single-blinded study of this phenomenon in six SCI men and three SCI women who underwent RPES a total of 71 times. The mean age of the subjects was 28.2 years (21-41), the mean time from injury was 6.0 years (0.5-15); there were three paraplegic and six quadriplegic persons: four were Frankel class A and five were class B. Although all subjects had moderate to severe spasticity, only four took antispasm medications; one had undergone surgery for implantation of an epidural stimulator. The effectiveness of RPES on spasticity was evaluated by each subject for frequency of spasms and interference of daily activities and by independent, blinded assessors for tone, frequency of spasms and DTRs; four patients underwent quantitative videotape analysis of the pendulum test and two underwent somatosensory evoked potentials (SSEPs) to evaluate electrical activity in the central nervous system. Treatment variables included varying probe sizes and number of stimulations. All subjects experienced good to excellent decrease in tone, frequency of spasms and interference with ADL from 3 to 24 hours depending on treatment variables used. Mean duration of relief was 8.2 hours.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Fertility options and success after spinal cord injury.

Over the past 9 years, the fertility potential for men with spinal cord injury and other neurological impairments has improved. Approximately 80% of men with spinal cord injury have semen (collected either by vibration or by electroejaculation using rectal probe) of sufficient quality to use in intrauterine insemination or in vitro fertilization. Assuming that other factors are equal, it would seem that length or level of injury are not dominating factors that control the quality of semen from these men.

Adult↗

The effects of rectal probe electrostimulation on spinal cord injury spasticity.

Spasticity is a common sequel of spinal cord injury (SCI) with well documented effects on daily activities and increased morbidity. In the course of our fertility studies using rectal probe electrostimulation (RPES) and SCI men to produce ejaculation, we observed that a majority of the men experienced significant improvement in their spasticity for many hours. This paper describes a preliminary effort to quantitate this phenomenon in 14 consecutive subjects treated for anejaculation on 65 occasions in our SCI Fertility Clinic. The effectiveness of RPES on spasticity was evaluated by pre- and post-RPES subject assessment and neurological examinations and follow-up self reports via telephone interviews. Six of the 14 patients (42%) experienced excellent relief following 30 of 33 RPES treatments; 4 (29%) had good to fair relief following 14 of 15 RPES treatments and 4 (29%) had no effect on all 17 RPES trials. The mean duration of relief was 9 hours (3-24). There was no relation between subject age, age of injury, level or completeness of injury or ejaculatory response with relief of spasticity. All men taking medications felt RPES was more effective than drugs in relieving spasms. No untoward effects were reported and 7 (50%) said they would use a home model for daily RPES, if available.

Adolescent↗

Rectal probe electrostimulation in the treatment of anejaculatory spinal cord injured men.

This paper reviews our experience with rectal probe electroejaculation (RPE) which is part of a larger effort to determine the correlates of successful ejaculation and fertility in SCI men. RPE is performed in the outpatient clinic using specially designed rectal probes. Over the past 18 months, we have attempted RPE on 38 occasions in 12 subjects (eight paraplegics and four quadriplegics) with an age range of 23-38 years and 0.5-18 years since onset of injury. Anterograde ejaculation occurred in nine subjects with improvement in percent motility and total live sperm count on repeated stimulations in five subjects. Significant retrograde ejaculation occurred in one person and sperm acceptable for artificial insemination (AI) was obtained from four subjects. The major side effects were mild dysreflexia (three subjects) and disruption of a normal bowel program (one subject). We conclude that RPE is a safe, relatively brief outpatient procedure and, with repeated stimulations, has a good potential for producing sperm acceptable for AI in selected patients.

Adult↗

Team care: an analysis of verbal behavior during patient rounds in a rehabilitation hospital.

Patient rounds are an important aspect of multidisciplinary team care. Team perceptions of ideally functioning rounds were compared with the actual communication patterns in rounds in a physical rehabilitation hospital. Perceptions of the patients' needs in the content areas of physical, psychosocial, and support systems were also compared with the actual distribution of content in rounds. Physicians spoke more (41%) and made more authoritative statements (62%) than did staff from any other discipline. The physicians participated far more than was perceived as ideal in all areas but the physical. Patients contributed only 9% of the discussion and less than 1% of authoritative statements. The physical content area was overemphasized (65%) and the psychosocial area was underemphasized (14%) when compared with the perceived needs of the patients. Interpretations of these findings and implications for investigation of the impact of team care are discussed.

Authoritarianism↗

The innovative rehabilitation team: an experiment in team building.

This article describes an effort by one rehabilitation team to create innovative approaches to team care in a medical rehabilitation hospital. The major arena for implementing change was the weekly patient rounds. We worked to increase patient involvement, developed a rounds coordinator role, used a structured format, and tried to integrate research findings into team decision making. Other innovations included use of a preadmission questionnaire, a discharge check list, and a rounds evaluation questionnaire. The impact of these changes was evaluated using the Group Environment Scale and by analyzing participation in rounds based on verbatim transcripts obtained prior to and 20 months after formation of the Innovative Rehabilitation Team (IRT). The results showed decreased participation by medical personnel during rounds, and increased participation by patients. The rounds coordinator role increased participation rates of staff from all disciplines and the group environment improved within the IRT. These data are compared with similar evaluations made of two other groups, which served as control teams. The problems inherent in making effective, lasting changes in interdisciplinary rehabilitation teams are reviewed, and a plea is made for other teams to explore additional ways to use the collective creativity and resources latent in the team membership.

Decision Making↗

Late effects of poliomyelitis. Part I: Report of five cases.

We present five case reports to illustrate the late effects of acute paralytic poliomyelitis occurring many years after recovery. We emphasize the importance of ruling out common medical causes for the symptoms and address the question of a "postpolio syndrome." The cause of progressive muscle weakness 30 to 40 years after recovery from poliomyelitis remains unknown.

Acute Disease↗

New problems in old polio patients: results of a survey of 539 polio survivors.

Presented are the results of a questionnaire survey on new health problems in 539 polio survivors. The most common new problems were fatigue, weakness in previously affected and unaffected muscles, muscle pain, and joint pain. The median time from polio to the onset of these problems ranged from 30 to 40 years. Factors at onset of polio most strongly associated with developing these new health problems were: being hospitalized, being over 10 years old, being on a ventilator, and having paralytic involvement of all four limbs. The differential diagnoses of these new problems, implications for treatment and areas for future research are discussed.

Activities of Daily Living↗

Drug absorption in spinal cord injury.

The absorption characteristics of drugs in spinal cord injury (SCI) were studied using an actively transported drug [riboflavin (RBF)] and a passively absorbed drug [acetaminophen (ACE)]. RBF absorption was studied following oral administration of 150mg RBF as 5'-phosphate flavin mononucleotide in ten clinically complete quadriplegic patients (C1 to C7, two to 15 months post-onset) and six control subjects matched for age, sex, and weight. Urinary excretion was measured under fasting (F) and nonfasting (NF) conditions for time to peak, peak excretion rate, and percent dose recovered. The results showed a significant difference (p less than 0.05) for all parameters between F and NF conditions for both the SCI and able-bodied groups. However, there was no significant difference for the same parameters between the two groups. ACE absorption was studied in five SCI clinically complete quadriplegic patients (C1 to C7, two to 15 months post-onset following the administration of a 650mg tablet. Serum samples were analyzed for ACE content and showed: time of peak, 1.35 +/- 0.6hr; maximum serum level, 6.8 +/- 2.68 micrograms/ml; half-life, 2.89 +/- 1.81hr; absorption lag time, 18.1 +/- 1.8min; area under the serum level-time curve, 21.8 +/- 6.7 micrograms/.hr/ml. When compared to able-bodied population data in the literature, there was a significant increase in the time to peak and lag time, and a decrease in the maximum ACE serum concentration obtained.(ABSTRACT TRUNCATED AT 250 WORDS)

Acetaminophen↗

Results of a survey of 201 polio survivors.

We present the results of a survey on the late effects of poliomyelitis in 201 persons. The most common new problems were fatigue, weakness in previously affected and unaffected muscles, muscle pain, and joint pain. The median time from poliomyelitis to onset of new problems ranged from 30 to 40 years. Factors at onset of polio most strongly associated with development of these late effects of polio were (1) hospitalization (P less than 0.00001), (2) age greater than 10 years (P less than 0.00001), (3) ventilator use (P less than 0.0029), and (4) paralytic involvement of all four limbs (P less than 0.0240). The differential diagnosis of these new problems, implications for treatment, and areas for future research are discussed.

Activities of Daily Living↗

Metabolic and endocrine changes in spinal cord injury: III. Less quanta of sensory input plus bedrest and illness.

This is the fourth article (Part III) of a 4-part series which provides a comprehensive review and analysis of the pertinent literature published over the last 25 years on the metabolic and endocrine consequences of spinal cord injury (SCI). The studies on SCI patients reviewed in this article include reports and investigations concerning plasma ACTH, plasma and urine corticosteroids and their diurnal variations at rest and during stress, of fasting values of TSH and growth hormone, thyroxine, testosterone, and of urinary skin collagen metabolites and urinary tryptamine. Information from articles reviewed here is organized under the following headings: Problems studied, Methods of investigation and results, Conclusions, Summary of results, Discrepancies, Areas of research needed, and Practical clinical implications. Highlights of pertinent data contained in the original articles are organized in tables to facilitate direct comparisons between similar studies and between data on healthy and subjects with spinal cord injuries.

Adrenal Cortex Hormones↗