Biomedical subjects

L Roux

Publications and source records attributed to L Roux.

76 records · Page 5Linked to original sources

PubMed1975

Isolation of RNA transcripts from the entire Sendai viral genome.

Three classes of viral transcripts (18S, 24S, and 33S) were isolated from viral ribonucleoproteins in Sendai virus-infected cells. Hybridization studies with virion minus strand genome RNA demonstrated that the 18S RNA contained transcripts from 60% of the viral genome while the 33S RNA contained transcripts from the entire viral genome. Brief heat of ME2SO treatment of the 33S RNA demonstrated that this RNA was composed of two classes: RNA which continued to sediment at 33S (33S RNA) and 18S RNA aggregates (18S RNA). The 33S RNA was determined to be a transcript from the 40% of the viral genome not protected by the 18S RNA. The aggregated 18S RNA does not appear to be an artifact of isolation.

Culture Techniques↗

PubMed1975

[Effect of tranquilizer doping on the muscular activity on the sport horse. I. -- Acepromazine (author's transl)].

Doping with tranquilizers has appeared recently in horse-back riding sports. In this paper we study the effects of acepromazine, one of the main tranquilizers used, on various physiological and biochemical aspects of muscular activity (cardiac and respiratory rhythms, seric rates of glucose, urea, protein, creatine phosphokinase, glutamate oxalacetate transaminase, alkaline phosphatase). A low dose (0.02 mg/kg) of acepromazine is injected; the evolution of the variables is studied before and after a standardized effort. After the effort and during recuperation, acepromazine administration causes: -- a decrease of respiratory rhythm and seric protein rats, -- an increase of creatine phosphokinase rate. A discussion of these results suggests that acepromazine depresses the respiratory centers and has a possible toxic effect on the muscle cell.

Acepromazine↗

PubMed1975

[Effect of tranquilizer doping on the muscular activity of the sport horse. II. -- Diazepam (author's transl)].

The practise of repeated doping of the sport horse led us to examine its effects on the health of the animal, and particularly on muscular activity. The main doping agent used at present (acepromazine) has already been studied (COURTOT et al., 1974). In this paper, we study the secondary effects of diazepam, a derivative of the benzodiazepine series, which is being used more and more frequently on horses. In treated animals as compared to controls, we observe: -- a slight respiratory depression related solely to effort, -- an increase in seric creatine phosphokinase rate with no apparent relation to effort. A discussion of these results leads to the conclusion that the secondary effects of diazepam are: -- a punctual effect on respiration as related to decreasing effort intensity, -- a toxic effect on muscle.

Animals↗

PubMed1974

Protein kinase associated with Sendai virions.

A protein kinase activity has been found associated with purified Sendai virions. Most of the virion proteins and exogenous protamine served as substrates for this enzyme.

Adenosine Triphosphate↗