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Biomedical subjects

L Rosenthall

Publications and source records attributed to L Rosenthall.

At least 109 records · Page 6Linked to original sources
PubMed1978

99MTc-metyhlene diphosphonate concentration in soft tissue malignant fibrous histiocytoma.

Four cases of non-calcifying soft tissue malignant fibrous histiocytoma are presented which showed concentration of 99mTc-methylene diphosphonate. Angiography was performed in one of the patients and it featured hypervascularity, tumor staining and early draining veins indicative of arteriovenous shunting. As with other extraskeletal non-calcifying entities which exhibit enhanced uptake of 99mTc-phosphate complex, the mechanism of concentration is largely conjectural. Malignant fibrous histiocytoma can be added to the expanding list of conditions which may portray in avidity for 99mTc-phosphate complex.

Aged↗
PubMed1978

Radionuclide demonstration of relative increased blood flow in uniappendicular secondary hypertrophic osteoarthropathy.

A rare case of hypertrophic osteoarthropathy (HO) limited to one lower extremity is described in a male with a history of familial polyposis coli and bilateral aortofemoral grafts. The precise etiology remains unknown. Radiography depicted the HO, but 99m Tc-methylene diphosphonate imaging showed more extensive involvement. An intra-aortic injection of 99m Tc-macroaggregates of albumin portrayed a larger blood flow to the involved limb compared to the contralateral extremity. The major part of this increase was in bone rather than in the adjacent soft tissue.

Angiography↗
PubMed1978

Assessment of the utility of gallbladder imaging with 99mTc-IDA.

Cholescintigraphy was performed in 113 patients of whom 38 had normal gallbladders, 37 had acute cholecystitis and 38 had chronic cholecystitis. The radiopharmaceuticals used in the study were either 99mTc-dimethyl acetanilide iminodiacetic acid or 99mTc-paraisopropyl acetanilide iminodiacetic acid, both of which performed equally well. All patients with non-visualized gallbladders had cholecystitis, but visualization did not exclude disease. The rapidity of obtaining the results (within one hour), the complete absence of untoward reactions to the radiopharmaceuticals, the much lower frequency of subtle or indeterminate results, the ability to render useful information in the presence of moderate jaundice and the lack of interference from overlying intestinal contents establishes these radionuclide agents as superior to both radiographic oral and intravenous cholangiography in the investigation of the acute abdomen.

Acetanilides↗
PubMed1978

Serial 67Ga-citrate imaging during treatment of acute osteomyelitis in childhood.

To test the hypothesis that abnormalities on 67Ga-citrate scans parallel the clinical course of acute osteomyelitis and revert to normal with successful antibiotic therapy, serial scans were performed in ten children. Scans improved markedly within the first two to four weeks of treatment, but abnormalities persisted at six or more weeks in over 50% of the cases, despite complete clinical resolutions of disease.

Acute Disease↗
PubMed1978

Diagnosis of hepatobiliary disease by 99mTc-HIDA cholescintigraphy.

99mTc-HIDA is concentrated by the hepatocytes and excreted into the biliary system; the gallbladder, common bile duct, and early accumulation in the duodenum are visualized within 30 minutes of intravenous administration. The authors studied the utility of 99mTc-HIDA imaging in both acute and chronic cholecystitis and hepatobiliary disease in the presence of jaundice: (a) all normal gallbladders exhibited filling, (b) absence of visualization indicated gallbladder disease and/or cystic duct obstruction, (c) visualization of the gallbladder after cholecystokinin-induced emptying excluded an obstructed cystic duct and acute cholecystitis, and (d) a definitive diagnosis of hepatocellular disease, partial and complete obstruction, is possible in jaundiced patients with hyperbilirubinemias up to 5 mg%. Beyond that level, 99mT-HIDA imaging was of qualified value. The technique is useful in assessing biliary drainage in jaundiced patients with surgically altered biliary tract anatomy.

Acute Disease↗
PubMed1978

Clinical experience with the newer hepatobiliary radiopharmaceuticals.

Technetium 99m-labelled hepatobiliary imaging agents provide high resolution images not previously possible with rose bengal labelled with iodine 131. This has prompted a re-examination of the utility of these radioactive pharmaceuticals. We have found that the newer methodology provides a rapid, innocuous and accurate means of excluding acute cholecystitis from the diagnosis in patients with symptoms suggestive of this disease and of assessing surgically altered biliary anatomy. In the presence of moderate bilirubinemia, up to about 85.5 to 103 mumol/L [5 to 6 mg/dL], a definitive distinction can be made between medical and surgical jaundice.

Acetanilides↗
PubMed1977

Observations on the sequential use of 99mTc-phosphate complex and 67Ga imaging in osteomyelitis, cellulitis, and septic arthritis.

Sequential studies with 99mTc-methylene diphosphonate (99mTc-MDP) and 67Ga were performed in 40 patients to determine the role of each agent in evaluating osteomyelitis, cellulitis, and spetic arthritis. Apart from the value of 67Ga in distinguishing cellulitis from osteomyelitis, it is a good adjuvant to 99mTc-MDP imaging in chronic osteomyelitis to identify continuing or recurrent sepsis and localize the focus of infection more precisely.

Adult↗
PubMed1977

Technetium-99m-pyrophosphate bone scans in hyperparathyroidism.

Most patients with primary hyperparathyroidism have normal 5-hr bone-to-soft-tissue ratios for 99MTc-pyrophosphate. In contrast, all five patients with advanced secondary hyperparathyroidism in this study showed significant (p less than 0.001) increases of bone uptake. In the early period after parathyroidectomy, there was no quantitative or qualitative change in uptake. A limited decrease of bone uptake was observed only after prolonged periods of observation. In itself, parathyroid activity seems to have little direct influence on bone uptake of 99MTc-pyrophosphate.

Adolescent↗
PubMed1977

Clinical comparison of 99mTc-labeled preformed phytate colloid and sulfur colloid: concise communication.

An in vitro preformed colloid preparation of 99mTc-Sn-phytate was compared both qualitatively and quantitatively with a commercial 99mTc-sulfur colloid kit in 30 patients. The degree of liver and spleen deposition of radiocolloid was, for practical purposes, the same. A slightly higher background was visually noted in 33% of the patients receiving preformed colloidal 99mTc-Sn-phytate, but it did not interfere with the diagnostic quality of the liver and spleen images. The only advantage of the phytate compound was a preparation time of less than 5 min.

Colloids↗
PubMed1976

The role of radionuclide imaging in disease of the alimentary tract.

The current status of radionuclide imaging studies of the liver, spleen, and pancreas is reviewed. Although current instrumentation and radiopharmaceuticals allow considerably better images than in the past, the overall accuracy of detecting liver metastases remains at 80%. The specificity of detecting hepatic space occupying disease has been enhanced by additional radionuclide studies which reveal the vascular and metabolic properties of the lesion.--The frequency of spleen imaging has increased since 99mTc-labeled colloids have been used. In most instances, it is obtained as a coincidental portion of the liver scintigraphic examination although it has significant primary indications such as in the elucidation of masses in or trauma to the left upper quadrant of the abdomen.--Selenium-75 selenomethionine pancreatic scintigraphy is best performed with serial Anger Camera images. Interfering hepatic activity is best removed by electronic subtraction techniques; if available. Careful attention to patient selection for the procedure is important. The mean true-positive and negative rates are 86% and 20%, respectively.

Humans↗
PubMed1976

Observations on the mechanism of 99mTc-labeled phosphate complex uptake in metabolic bone disease.

This communication describes a series of clinical and animal in vivo and in vitro investigations designed to elucidate the mechanism of 99mTc-Sn-phosphate complex concentration in metabolic bone disease. Rachitic and lathyritic animals were used as experimental models. Based on these studies it is concluded that 99mTc alters the pharmacology of the phosphate complexes, in particular pyrophosphate, which was the test agent most extensively employed, so that the usual affinity for mineral is for the greater part replaced by organic matrix binding. There is also evidence to suggest the immature collagen moiety of the organic matrix is the prime target of 99mTc-Sn-phosphate complex binding. Specifically, the aldehyde groups of the collagen molecule are suspected as being the major site of interaction.

Aminopropionitrile↗
PubMed1976

Assessment of bone viability by scintiscanning in frostbite injuries.

Radionuclide bone imaging with a radiotechnetium-labeled phosphate (99mTc-methylene diphosphonate) has been employed to study the extremities injured by frostbite. The degree of accretion of the radiopharmaceutical in bone is dependent on the integrity of the vascular supply. This property has been used successfully to distinguish viable and nonviable bone.

Adult↗
PubMed1976

Progressive multifocal leukoencephalopathy.

The radionuclide, radiographic and pathologic findings in a patient with progressive multifocal leukoencephalopathy were correlated. Radionuclide imaging demonstrated the largest two of the many lesions observed at pathology. On repeated studies, one of the lesions developed a "doughnut" sign due to central necrosis. Cerebral angiography disclosed only one lesion which was initially suggestive of tumor encasement, but four weeks later, this deteriorated into an avascular zone. There were no characteristic features of the lesions demonstrated by radionuclide imaging and cerebral angiography that could be specifically attributed to progressive multifocal leukoencephalopathy.

Carotid Arteries↗
PubMed1976

Observation of the use of 99mTc-phosphate imaging in peripheral bone trauma.

The utility of 99mTc-phosphate imaging of fractured bones adjacent to joints soon after injury is examined. Joints usually respond to trauma by a generalized increased regional concentration of the radiopharmaceutical; but with careful attention to technique, a superimposed focal deposition due to the fractured bone can be seen. Fractures which were initially indefinite or which seemed normal at radiography were revealed as early as 7 hours after injury. In our experience, failure to show a focal concentration beyond 3 days excludes a fracture. However, a focal concentration need not necessarily represent a gross fracture; a ligamentous avulsion of a bone chip and/or periosteum could yield the same picture and not be disclosed by radiography. Radionuclide imaging of joint fractures is a useful adjunct to clinical assessment.

Adult↗
PubMed1976

Observations of radionuclide imaging in hypertrophic pulmonary osteoarthropathy.

99mTc pyrophosphate was employed in the study of patients with hypertrophic pulmonary osteoarthropathy. Several facts emerge when comparing the radionuclide, radiographic and clinical findings. Radionuclide imaging reveals the presence and extent of subperiosteal activity with greater clarity than does radiography. Synovitis associated with the syndrome is readily disclosed, and the regression of the skeletal manifestions following excision of the pulmonary lesion can be documented.

Female↗