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Biomedical subjects

L Rosen

Publications and source records attributed to L Rosen.

At least 91 records · Page 5Linked to original sources
PubMed1989

A preliminary investigation of the pragmatic abilities of a group of language disordered children.

The communicative acts, conversational acts, and breakdown repair abilities of six language-disordered children with a syntactic age of +/- 3 years old as determined by the LARSP (Crystal, Fletcher, Garman: 1976) were investigated. Sampling of each subject involved two separate naturalistic interactions with a familiar adult and a language disordered peer. The data obtained from the transcriptions were analysed in terms of linguistic and nonlinguistic behaviours on the Communication Profile by Wollner and Geller (1982). Specific patterns of deficit and strengths were observed and these trends were related to recent literature in this area. The study emphasises that there is as much heterogeneity in the pragmatic skills as in the other communication skills of language disordered children, although this is due to some extent to the limitations of assessment in naturalistic settings. It also indicates individual areas of pragmatic deficit that require remediation.

Child, Preschool↗
PubMed1988

Regression of oral hairy leukoplakia after orally administered acyclovir therapy.

To define the role of Epstein-Barr virus (EBV) in the pathogenesis of oral hairy leukoplakia, 13 human immunodeficiency virus-seropositive men with clinical and histologic evidence of oral hairy leukoplakia were enrolled in an open-label trial of orally administered acyclovir therapy (3.2 g/d for 20 days). Of six patients who received therapy, five exhibited clinical regression. Once therapy was discontinued, recurrences occurred in all responders. Among seven patients who refused therapy, no spontaneous remissions occurred. Before therapy, EBV replication within the leukoplakia was demonstrated by immunofluorescence tissue staining or electron microscopy in five patients who were studied. Human papillomavirus was not detected by immunocytochemistry or electron microscopy from tissue specimens of six patients. After therapy, biopsy specimens from two patients with complete responses revealed a normalization of histologic abnormalities and an inability to detect EBV in previously involved mucosa by immunofluorescence or in situ DNA hybridization assays. It was concluded that EBV replication within the epithelial cells of the tongue is necessary for the development of oral hairy leukoplakia.

Acyclovir↗
PubMed1988

Development of an inflammatory bowel disease registry.

Inflammatory Bowel Disease is characterized by two major entities, Crohn's Disease and Ulcerative Colitis. These bowel diseases have associated problems involving the eyes, joints, skin, kidneys, immunological system, hepatobiliary system, and psychiatric disturbances. A regional IBD registry encompassing 18 hospitals and IBD specialists in east/northeast Pennsylvania was established to promote awareness of the clinical and epidemiological aspects of the disease. Results of this data collection effort will be shared with patients and physicians through the use of newsletters and symposia. A Basic History (HX) form, an Operative Data (OR) form, and an Annual Follow-up (FU) form was used to collect relevant data. Participation is voluntary and all information is confidential.

Humans↗
PubMed1988

Anoplasty.

Because of the anatomic variations of stricture or ectropion, the surgeon should master several of the techniques quoted here. These methods may have to be modified in selected patients, but all changes should be based on sound anorectal plastic principles.

Anal Canal↗
PubMed1988

An orbivirus of mosquitoes which induces CO2 sensitivity in mosquitoes and is lethal for rabbits.

An orbivirus, JKT-7400, isolated from Culex mosquitoes in Indonesia, replicated to a high titer and induced cytopathic effects in Aedes albopictus cell cultures. The virus produced lethal sensitivity to carbon dioxide in Culex and Aedes mosquitoes as well as in Drosophila melanogaster fruit flies but was not the agent of the hereditary sensitivity to carbon dioxide previously described for Culex quinquefasciatus. When injected intravenously in high doses, JKT-7400 virus was lethal for rabbits, apparently without replicating to a significant extent. It was not pathogenic for adult mice inoculated intravenously or for adult or suckling mice inoculated intracerebrally and intraperitoneally. Unlike an orbivirus isolated from Culex mosquitoes in China, JKT-7400 did not interfere with the replication of Japanese encephalitis virus in mosquitoes.

Aedes↗
PubMed1988

Further observations on the mechanism of vertical transmission of flaviviruses by Aedes mosquitoes.

As previously observed for dengue viruses, vertical (i.e., transgenerational) transmission of Japanese and St. Louis encephalitis viruses by Aedes albopictus takes place when the fully formed egg, enclosed in the chorion, is oviposited. The demonstration of such a mechanism for three flaviviruses suggests that vertical transmission of all mosquito-borne flaviviruses may occur in the same manner.

Aedes↗
PubMed1988

Vertical transmission of dengue viruses by Aedes mediovittatus.

Aedes mediovittatus, a forest and peridomestic mosquito found in the Caribbean area, has previously been shown to be highly susceptible to oral infection with dengue viruses in the laboratory. In the present study, the species was found to transmit all four dengue serotypes vertically (i.e., from one generation to another) at rates much higher than any observed previously for flaviviruses in mosquitoes. Vertical transmission rates (the percentage of parent females transmitting to one or more progeny) ranged up to 95%. Filial infection rates (the percentage of infected progeny) varied widely by family but rates greater than or equal to 20% for individual families were not uncommon. Since Ae. mediovittatus feeds readily on humans and is relatively abundant, there is no apparent reason why it would not serve as a vector of dengue. If it does, vertical transmission of the virus in this species would contribute to the maintenance of viral endemicity.

Aedes↗
PubMed1987

The Bacon pull-through procedure.

Twenty-eight patients who underwent the Bacon pull-through procedure for carcinoma of the midrectum were reviewed retrospectively. The results were comparable to low anterior resection and abdominoperineal resection. Although the indications are limited, it is a viable option in a highly selected group of patients.

Aged↗
PubMed1987

Endoscopic retrieval of foreign bodies from the rectum.

A technique is described and illustrated by case reports wherein removal of foreign bodies of the rectum is simplified by using the flexible sigmoidscope. Evidence from the literature indicates that delayed perforation is rare in this situation, and that outpatient management would suffice for most patients.

Adult↗
PubMed1987

Serological evidence of Hantaan-related viruses in Hong Kong.

Sera from rats (Rattus norvegicus), domestic animals and man in Hong Kong were studied by immunofluorescent antibody assay and plaque reduction neutralization tests for evidence of infection by Hantaan-related viruses. Antibody probably arising from infection by Seoul or a Seoul-like virus was detected in rat and human sera (and one pig serum), highlighting the potential public health importance of this group of viruses in Hong Kong, and in the region.

Adolescent↗
PubMed1987

Vertical transmission of dengue viruses by mosquitoes of the Aedes scutellaris group.

Seventeen strains of mosquitoes belonging to 12 species in the Aedes scutellaris subgroup were tested for an ability to transmit one or more dengue virus serotype(s) vertically. Strains of virus employed for dengue types 1, 2, 3, and 4 were from Fiji, Bangkok, Burma, and Medan, respectively. After parental females were infected by intrathoracic inoculation, F1 larval and pupal progeny were tested for the presence of virus by inoculating aliquots of triturated suspensions into Toxorhynchites amboinensis mosquitoes. Dengue type 1 was transmitted vertically by 11 strains of mosquitoes representing 8 species with the highest filial infection rates observed for Ae. cooki (1.2%). Vertical transmission of the other dengue virus serotypes was observed for fewer species of mosquitoes, however the filial infection rates of those demonstrating vertical transmission were between 1%-2% for types 2 and 3, and about 0.5% for type 4. Tests with the progeny of individual Ae. cooki and Ae. polynesiensis infected with dengue virus types 1 and 3, respectively, showed that approximately greater than or equal to 50% of the parental females transmitted virus to their progeny. Highest filial infection rates were 6.7% for Ae. cooki and 4.6% for Ae. polynesiensis.

Aedes↗
PubMed1987

Overwintering mechanisms of mosquito-borne arboviruses in temperate climates.

It can be concluded from the data cited that transovarial transmission is a plausible explanation for the overwintering of mosquito-borne bunyaviruses of the California serogroup. Vertical transmission of mosquito-borne flaviviruses could explain the overwintering of this group of viruses, but this is far from having been established. At present, the mechanism by which mosquito-borne alphaviruses pass the winter is obscure.

Alphavirus↗
PubMed1987

New spiroplasmas from insects and flowers: isolation, ecology, and host association.

Eight spiroplasma strains from insects and one from spring flowers failed to react with antisera specific for any of the 11 described spiroplasma groups, with sera directed against spiroplasma Group I subgroups, or with sera directed against two unnumbered groups previously reported to occur in tabanid flies. Strains, all from Maryland, were isolated from the hemolymph of the spotted cucumber beetle Diabrotica undecimpunctata and the lampyrid beetle Ellychnia corrusca, and the guts of the cantharid beetles Cantharis bilineatus and C. carolinus. Other strains were obtained from a tabanid fly, Tabanus gladiator and from the firefly Photuris pennsylvanica in Maryland and from the mosquito Culex tritaeniorhynchus in Taiwan. An isolate from pooled Cicadulina bipunctella leafhoppers in Syria apparently represented a unique group. A single isolate from spring flowers in Oklahoma also appeared to be unrelated to existing groups or subgroups. One-way deformation tests using sera prepared against known beetle and tabanid spiroplasmas showed each of the above strains to be unique. Although these results strongly indicate that the nine strains studied are representatives of unique new spiroplasma groups, the formal designation of new groups awaits fulfillment of recently proposed criteria.

Animals↗
PubMed1987

Mechanism of vertical transmission of the dengue virus in mosquitoes.

Both experimental and field data suggest that some tropical mosquito-borne flaviviruses, such as dengue and yellow fever, survive dry seasons by vertical (i.e. transgenerational) transmission in their mosquito hosts. Although vertical transmission of arboviruses in mosquitoes is considered to be transovarial in nature, observations reported here indicate that this is probably not true for dengue virus. Rather, infection of the next generation with this virus apparently takes place when the fully developed egg, enclosed in the chorion, is fertilized at the time of oviposition. In contrast to transovarial transmission, the latter mechanism permits the infection of progeny following a single maternal blood meal.

Aedes↗
PubMed1987

Sexual transmission of dengue viruses by Aedes albopictus.

Male Aedes albopictus experimentally infected with dengue virus types 1, 2, 3, or 4 transmitted their infection sexually to female Ae. albopictus. Such transmission was enhanced if the females had taken a bloodmeal 2 to 7 days prior to mating. Male Ae. albopictus also transmitted dengue virus vertically to their F1 progeny. Infected progeny were found among those derived from eggs laid greater than or equal to 73 hr after mating but not among those derived from eggs laid prior to that time. This suggests that virus probably was not transmitted directly to ova but, rather, underwent prior replication in the female genital tract. Female Ae. albopictus experimentally infected with dengue type 1 virus did not transmit their infection sexually to males. This finding supports the hypothesis that male mosquitoes naturally infected with dengue virus acquired their infection vertically.

Aedes↗
PubMed1986

Comparing predictive decision rules in postoperative CEA monitoring.

To evaluate the usefulness of serial postoperative carcinoembryonic antigen (CEA) assays, seven previously published decision rules for predicting tumor recurrence were compared retrospectively using CEA values from 214 patients followed 36 to 120 months after surgery for colorectal carcinoma. Decision rules employing cutoff values to predict tumor recurrence were found inadequate for the asymptomatic patient. This attenuation of prognostic usefulness appeared attributable to inadequacies of CEA assays for predicting late recurrences. From these analyses, elevated CEA results without other objective evidence might be insufficient to justify second-look surgery. In addition, late recurring tumors tended not to cause elevated CEA levels.

Adult↗