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Biomedical subjects

L Rolle

Publications and source records attributed to L Rolle.

At least 19 recordsLinked to original sources
PubMed1998

Congenital bilateral absence of vas deferens with a new missense mutation (P499A) in the CFTR gene.

We describe a congenital bilateral absence of the vas deferens (CBAVD) patient with a compound heterozygosity in the cystic fibrosis transmembrane regulator (CFTR) gene for a stop mutation W1282X and a new missense mutation P499A. The P499A is interpreted as a mild mutation whose phenotypic effects, in this case limited to the development of wolffian duct derivatives, are revealed only in combination with a severe CFTR mutation.

Adult↗
PubMed1998

[False penile shortness].

The rising interest on male genital aesthetics increased the number of patients complaining of short penis. therefore, the andrologist must be able to perform a correct diagnostic assessment and to make the correct therapeutical choice as well, even if there's no standard yet. The aim of this paper is to discuss some diagnostic troubles about penile shortness and, in particular, to explain the basic surgical strategies suitable for the treatment of "hidden penis".

Body Image↗
PubMed1995

[Psychosexual interventions combined with biologic therapy of erectile dysfunction].

The authors, beginning from che concept of erectile disorder with mixed pathogenesis, describe its clinical dimension. The psychic variables which prevent the use of biologic-andrologic therapy (FIC, penis prosthesis) are then considered: 1) psycho-sexual difficulties before the onset of the organic lesion; 2) the partner's relationship with the biologic-andrologic therapy; 3) the patients' relationship with the biologic therapy. A model of intervention (Group Psycho-sexologic Intervention) on the psychic variables interfering with the use of the biologic-andrologic therapy is then described. The authors end by considering the psychological impact and the possible psychoiatrogenicity of biologic-andrologic therapies.

Erectile Dysfunction↗
PubMed1995

[Italian centers that deliver treatment for male sexual dysfunction].

In agree with President and Committee of Andrological Italian Society (S.I.A.), authors have carried on a research to know: 1) main features of Italian Structures interested in male sexual dysfunction 2) actual trend in diagnosis and therapies of male sexual dysfunction, Authors report results and data about this research, particularly regarding new trends in therapia (therapy).

Delivery of Health Care↗
PubMed1995

[Penile prosthesis].

In this article the Authors, after describing the history of the penile prosthesis surgery and analyzing the technical progresses made in the last twenty years, offer their personal experience and data from the most recent literature about treatment of erectile dysfunction through the application af penile prosthesis, about the indications for the operation and the choice of the type of prosthesis. They also explain all the possible complications and eventual mechanical failures, which have considerably decreased in the last few years.

Erectile Dysfunction↗
PubMed1994

[The pharmaco-erection test].

Intracavernous administration of vasoactive drugs induces an erection in absence of erotic stimuli; we can use this property in the study of impotent patients, inducing the appearance on an erection to examine it in all its phases (FIC Test). In case of the appearance of a good erection, the test should rule out the presence of a penile arterial disease or of a corpora-veno-occlusive deficiency. When the administration of the drug does not cause complete tumescence, it is very probable that the erectile dysfunction is caused by arterial vascular alterations or by organic disorders of veno-occlusion mechanism, but we cannot exclude for a certainty a psychogenic dysfunction. In fact an excessive noradrenergic autonomic control, as during stress condition, may limit FIC Test response. Therefore we hope that more efficacious molecules will be available in a near future. Nevertheless, we consider the opportunity of enclosing tests in the diagnostic algorithm of impotent patients to reveal an excessive adrenergic tone, such as, for example, psychological tests, study of cavernous potential, or intracavernous catecholamine dosage.

Alprostadil↗
PubMed1994

[Psychological problems related to the sexual stimulation video (SSV) test in the diagnosis of erectile disorders].

The Authors analyze scientific community's attitude towards VSS test. Related psychological problems are examined: the doctor's fear to be accused of voyeurism, the doctor's inadequacy in "invading" patient's field of intimacy, the doctor's relationship with his own erotic fantasies and with pornography, the "castrating" aspects in hospital environment and so on.

Diagnosis, Differential↗
PubMed1993

[Transvaginal ultrasonography in the diagnosis of urethral diverticula].

The authors report their experience on transvaginal ultrasound in the diagnosis of urethral diverticula, using a high frequency linear probe, that is generally employed for transrectal prostate sonography. This non invasive method seems to be more reliable than voiding cystourethrography. This investigation may be recommended in women who have symptoms of lower urinary tract infection, urethral pain, dyspareunia, palpable mass of the anterior vaginal wall.

Diverticulum↗
PubMed1993

[Anatomo-functional changes in the cavernous body in the elderly].

The main histological alteration that happens to the structure of the corpora cavernosa as years go by, is the progressive increase of collagen fibers compared to the decrease of both smooth muscle and elastic fibers. This phenomenon is held responsible of consequences on the hemodynamic events occurring during the erection.

Aged↗
PubMed1992

Monoclonal antibody Ki-67 in the study of the proliferative activity of bladder carcinoma.

We studied the proliferative activity of bladder carcinoma using monoclonal antibody Ki-67, which is able to stain a nuclear antigen exclusively present in cells in the cell cycle, that is with activated deoxyribonucleic acid (DNA). We used this immunohistochemical technique on neoplastic tissue removed by transurethral resection from 101 patients. A significant correlation was observed (p less than 0.003) between cells with activated DNA and histological grading, even though within the context of each grade we observed tumors with a different proliferation index. Furthermore, we studied the location of the activated cells in the context of the tumor. In invasive tumors (stages T1 to T4) cells with activated DNA were always present at the base of implant of the tumor and in the neoplastic tissue that infiltrates the bladder wall. In regard to noninvasive tumors (stage Ta), in 57% of the cases most cells with activated DNA were present in the vegetative portion of the tumor and there were no recurrences at followup, while in 43% of the cases such cells were present also or especially at the base of implant of the tumor, near the lamina propria. In the latter patients we observed a 94% recurrence rate. These results suggest that the immunohistochemical assessment of the proliferative activity of transitional tumors of the bladder, using monoclonal antibody Ki-67, and the evaluation of the location of stained neoplastic cells provide a more reliable estimate of biological aggressiveness than that obtained with histopathological patterns alone.

Antibodies, Monoclonal↗
PubMed1991

[Reliability of transrectal echography in the early diagnosis of prostatic carcinoma: our experience].

The Authors observed a group of 20 patients, each of them suffering from prostatic carcinoma clinically localized in only one lobe. All patients were investigated by trans-rectal US tomography, performed with a 5 MHz linear sound, and by prostatic biopsy in both lobes. The Authors evaluate US tomography results in comparison with biopsy executed on the apparently normal lobe and appreciable sensibility, specificity and predictive capability of this method. The Authors believe that trans-rectal US tomography, after having considered sensitivity and specificity values is not to propose as a screening method for early diagnosis of prostatic carcinoma.

Biopsy, Needle↗
PubMed1991

[The treatment of priapism].

Priapism, that is a long lasting erection in absence of sexual desire and is sometimes painful, has represented a rare occurrence until few years ago; such occurrence has become much frequent since pharmaco-erection have been used. There are still many doubts about the etiopathogenesis of priapism, that anyway happens because of a long lasting pathological discrepancy between arterious flux to penis corpora cavernosa and venous down flowing. For to establish how and when we must treat priapism, it is very important to know the causes of it, so that we can use the more properly therapy for each case. It's possible to classify the therapies in the following ways: a) extracavernosa, b) located in the corpus cavernosum. These last ones are most used and include the punction and the drainage of the blood of the cavernous body and sometime the "shunt" spongio-cavernosum. The treatment must be effected without loss of time in those rare cases of spontaneous priapism. Indeed, according to our experience, it's not necessary to be extremely supporting for intervention for priapism post pharmaco-erection. In fact the wait of 8-10 hours reduces the number of invasive treatments, without danger for the integrity of cavernous tissue.

Anesthetics↗
PubMed1991

[Coagulation and fibrinolytic activity of blood from the corpus cavernosum].

Thrombosis in cavernous bodies during erection-induced blood stasis is a exceptional phenomenon. This observation, induced the Authors to study coagulative and fibrinolytic activities of blood in cavernous bodies during pharmacologically induced erection. The results of the tests performed show that the blood of cavernous bodies has a fibrinolytic activity 3 times higher than peripheral blood (FPLA = 277 +- 83 mm2) and did not decrease when plasma was incubated with anti t-PA. During middle length erections, this activity is not expressed and the absence of thrombi formation seems to be due to a slowing of blood coagulation processes. On the other hand, during long-lasting erections, fibrinolysis is induced resulting in a local consumption like coagulopathy. Fibrinolysis in this district is not related to high t-PA plasma levels.

Adult↗
PubMed1990

[Indications for correction of varicocele].

In this paper are indicated the procedures to correct the varicocele, based on both the experience of the Authors and the data from the literature. In prepubertal subjects only varicoceles of II and III grade should be operated, meanwhile the I grade can be followed up because it can improve spontaneously. In young people, the asymptomatic varicocele diagnosed incidentally, for instance when people are controlled for military duty, should be operated in order to avoid possible dyspermic troubles. Infertile Adults with varicocele should be always surgically treated but which have either contemporary elevated serum FSH values or different untreated infertility causes. The age limits between which a varicocele can be successfully treated, in order to improve the infertility, are not yet precisely identified. Patients over 35 years are unlikely to recover fertility after operation.

Adolescent↗