[Medico-legal activity in a hospital setting. A hospital specialty in itself].
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Biomedical subjects
Publications and source records attributed to L Roche.
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Nitrites and nitrates are often responsible for methemoglobinemy. Infants, on account of their greater sensibility to oxidizing agents, are particularly liable to poison by nitrates and nitrites. Sodium nitrite can be responsible for poisoning after accidental ingestion or owing to an overdose when preparing salt provisions, or because it has been mistaken for another product. Then it is often a case of collective poisoning. Nitrates generally produce methenoglobinemy when they are changed into nitrites under the influence of a bacterial proliferation or of a reductase held in plants. It happens with spinach and carrot soup. Nitrates can pollute municipal water supply and chiefly well water. As regards therapy, cases of methemoglobinemy have been noted after an overdose of potassium nitrate and especially of bismuth subnitrate. The treatment of methemoglobinemy caused by nitrates and nitrites is not specific: suppression of the oxidizing agents, oxygenation, prescription of reducing agents.
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A blood investigation was carried out on 3,030 volunteer blood donors and the results treated on a computer by multivariant analysis. The authors noted a depressor effect of the urban environment on the red and white cells, a rise in small lymphocytes and a reduction in monocytes in patients living in industrial areas. This stimulation of the lymphocyte system may be compared with the experimental results obtained by the same authors in animals.
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