Biomedical subjects

L Ries

Publications and source records attributed to L Ries.

21 records · Page 2Linked to original sources

PubMed1986

Temporal trends in breast cancer survival in Sweden: significant improvement in 20 years.

Of all women with a newly diagnosed breast cancer diagnosed in 1960-78 in Sweden, 57,068 (98%) were included in a complete follow-up during 1-19 years of observation. The 5-year mortality attributable to breast cancer was reduced by 29% from the period 1960-64 to 1975-78, which corresponded to an increase in relative survival by 10.5% (95% confidence limits, 7.2 and 13.8). There was a highly significant and regular trend during the study period toward a decrease in the annual hazard rate; this was confined to the first 4-5 years after diagnosis. The temporal trend toward improved survival was apparent in all age groups, but it was of lower magnitude among women younger than 45 years old.

Adult↗

PubMed1985

Long-term survival in 406 males with breast cancer.

Survival was analyzed during a follow-up period of up to 20 years in 406 (97%) of all 420 males in whom breast cancer was diagnosed in Sweden in 1960-1978. After correction for the expected mortality in the general population, cumulated survival rates (with 95% confidence limits) of 66 (58.7-72.5)% and 52 (42.0-62.1)% at 5 and 10 years respectively were found. These figures and the general pattern of relative survival rates were in close accordance with those noted in a concomitant series of female breast cancer. There was a trend toward slightly improved survival rates during the period of study and the median survival times were 3.9, 4.8 and 7.2 years for patients diagnosed in 1960-64, 1965-69 and 1970-74 respectively. Age at diagnosis was seemingly unrelated to the long-term relative survival. We conclude that, except for a slightly higher mean age at diagnosis in males, there is a striking similarity in the natural history of breast cancer between men and women after initial treatment, with an excess death rate which still persists at long-term observation.

Adolescent↗

PubMedDate not supplied

Survival results depend on the staging system.

The results of expressing patient outcome are compared using two staging systems: localized, regional, and distant (LRD) and the TNM of the American Joint Committee on Cancer (AJCC). Expressing patient outcome depends on the staging system used. There is overlap between the stage definitions of the LRD and the TNM. A single stage in the LRD may include more than one stage grouping of the TNM and vice versa. For most sites, "localized" provides lower survival rates than stage I of the TNM. The TNM provides more precise information about prognosis because its definitions reflect the latest survival information and diagnostic technology. Time trends can be measured only with the LRD because of its stability over the years. The precision of the TNM has been achieved at the expense of time trend analysis. The LRD is usually not an acceptable end point for the assessment of early cancer detection.

Breast Neoplasms↗