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Biomedical subjects

L R Weitkamp

Publications and source records attributed to L R Weitkamp.

At least 91 records · Page 5Linked to original sources
PubMed1975

The linkage relationships of HL-A with other genetic marker systems.

Data on the linkage relationships of HL-A with 31 autosomal genetic markers are presented. Among 40 markers for which some information on the linkage relationship with HL-A is available, four (PGM3, GBG, Ch and Pg) have lod scores greater than +3. The most likely order for the polymorphic systems tentatively assigned to chromosome 6 is Kell: Pg:(HL-A,GBG):Ch:PGM3:P.

Blood Group Antigens↗
PubMed1975

Probable genetic linkage between a locus for human urinary pepsinogen and the HL-A loci.

The genetic basis of familial variation in the relative intensities of human urinary pepsinogen isozymes is not completely clear from family studies. An investigation of the linkage relationships of pepsinogen isozyme 5, considering only segregation for the presence or absence of Pg 5, yields a peak lod score of 4.1 at theta = .1 for linkage with HL-A1 or HL-A2. Added to data from segregation interpreted according to a scheme proposed for the inheritance of intensity differences in Pg 5, the peak lod score becomes 3.0 at theta = .2. Data derived from the segregation of pepsinogen isozyme 4, possibly determined by an allele to that controlling the presence or absence of Pg 5, further reduces the total lod score at theta = .2 to 2.9. The results indicate probable linkage between a locus for urinary pepsinogen and the HL-A loci, but are insufficient to permit any conclusion concerning possible heterogeneity in the linkage relationships of Pg 4 and Pg 5 to HL-A.

Black People↗