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Biomedical subjects

L R Weitkamp

Publications and source records attributed to L R Weitkamp.

At least 55 records · Page 3Linked to original sources
PubMed1982

Genetics of Standardbred stallion reproductive performance.

Reproductive performance of 10 Standardbred stallions was related to the probability that the embryo resulting from a given mating would be heterozygous for transferrin or plasma esterase. Fertility, measured by foaling rate per insemination or by foaling rate per year, showed a highly significant regression on the probability of offspring heterozygosity for transferrin and, to lesser extent, for esterase. Substantial differences between stallions in the slope of the regression line and no deficiency of foals homozygous for either protein suggests that the relationship to fertility is indirect, probably a reflection of the amount of outcrossing between lines within the breed. An example of the potential impact of maximizing the probability of foal transferrin heterozygosity on the productivity of an actual farm is presented.

Animals↗
PubMed1981

Depressive disorders and HLA: a gene on chromosome 6 that can affect behavior.

To determine whether HLA-linked genes on chromosome 6 influence susceptibility to depressive disorders, we tested hypotheses concerning the distribution of HLA haplotypes among specific constellations of affected and unaffected family members. HLA haplotype identity among pairs of affected siblings in families with two affected siblings and among pairs of older unaffected siblings in families with one or two affected siblings was increased over random expectation (P less than 0.005). There was no increase in HLA haplotype identity among affected siblings in sibships with more than two affected members. When parents had a relative difference in estimated load of genes for susceptibility, HLA haplotypes were randomly transmitted to unaffected or affected children from the affected, "high-load" parent, but not from the unaffected, "low-load" parent (P less than 0.001). These results locate a gene contributing to susceptibility to depressive illness on chromosome 6 and provide a second example of the value of the hypotheses in defining the genetic bases of nonmendelian, familial diseases.

Adolescent↗
PubMed1981

Familial Alzheimer's disease in two kindreds of the same geographic and ethnic origin. A clinical and genetic study.

Alzheimer's disease (AD) occurred in 37 individuals from two kindreds of Jewish ancestry with a mode of transmission suggesting an autosomal dominant genetic trait. Both kindreds originated from Byelorussia and spoke the Lithuanian dialect of Yiddish. In one of the two families one case of pathologically confirmed AD occurred with clinical and neuropathological signs of Parkinson's disease. In the other family one case of amyotrophic lateral sclerosis and one case of Down's syndrome occurred, both without clinical or pathological signs of AD. In the single kindred tested, a study of the chromosome 6 markers HLA, Bf and GLO failed to reveal a correlation between the transmission of AD and the segregation of these markers. The association of increased aneuploidy of peripheral blood chromosomes with AD was not confirmed in either of these families. Genetic differences between the familial and the sporadic form of AD are discussed.

Adult↗
PubMed1981

HLA and disease: predictions for HLA haplotype sharing in families.

An analysis of published data on the segregation of HLA haplotypes in families with more than one individual affected with insulin-dependent diabetes mellitus or multiple sclerosis yields three conclusions: (1) In families with unaffected parents, affected sib pairs are much more often HLA haplotype identical in sibships with two affected sibs than in sibships with three or four affected sibs (P less than .01). (2) In families with unaffected parents and HLA half-identical affected sibs, well siblings more often receive the single haplotype not found in the affected sibs than is expected by chance (P less than .05). (3) In families with one affected parent, well siblings of affected individuals may share with the affected child a haplotype from the unaffected parent less than 50% of the time (P less than .10). These results are consistent with the premise that in some non-Mendelian, familial, HLA-associated disease more than one gene may contribute to susceptibility to the disorder.

Diabetes Mellitus, Type 1↗
PubMed1980

Genetic marker studies in a family with unipolar depression.

A study of genetic markers was undertaken in a kindred containing 19 individuals affected with a depressive illness. The pedigree was selected for study because the distribution of affected family members is consistent with transmission of an autosomal gene for susceptibility to psychiatric abnormality. Evidence against linkage of the postulated dominantly transmitted susceptibility gene with 29 segregating marker loci, including HLA, excluded the postulated gene from 6% of the autosomal genome. However, the distribution of HLA haplotypes in affected sibling pairs and within the family as a whole is compatible with the hypothesis that expression of affective disorder in this family depends in part on an HLA-linked susceptibility gene.

Adolescent↗
PubMed1979

Equine peptidases: correspondence with human peptidases and polymorphism for erythrocyte peptidase A.

Equine erythrocyte peptidases were compared to the six human erythrocyte peptidases, A, B, C, D, E, and F, regarding substrate specificity, relative activity, and electrophoretic mobility. Five equine erythrocyte peptidases appeared homologous to human peptidases A, B, D, E, and F. In contrast to human, equine peptidase C was absent in red cells, although it was weakly active in white cells. On the other hand, an equine peptidase, probably homologous to human peptidase S, was weakly active in red cells as well as present in white cells. Polymorphism for equine erythrocyte peptidase A is reported.

Animals↗
PubMed1978

Concerning the linkage relationships of the Gc and MNSs loci.

Lod scores for the linkage relationships of the Gc and MNSs loci are presented for data from a number of published pedigrees and 103 new families. Linkage may be excluded at a recombination frequency of less than 25% in males and 30% in females.

Alpha-Globulins↗