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Education, Nursing, Baccalaureate↗
Biomedical subjects
L R Moore
Publications and source records attributed to L R Moore.
Antagonism of fentanyl-induced respiratory depression with nalmefene.
We determined the ability of a new opioid antagonist, naimefene, to prevent fentanyl-induced respiratory depression in 8 healthy male volunteers. Ventilation and pulmonary function were measured with the respiratory inductive plethysmograph (RIP), which is non-invasive and requires no connection to the airway. Each volunteer was tested two times on different days. During the first session, each volunteer was monitored for one hour of baseline measurement followed by 4 hourly injections of fentanyl (1 microgram/kg) administered in an open-label manner. In the second session, the subjects were monitored for one hour after 1 mg of intravenous nalmefene was administered. Intravenous fentanyl or identical placebo were then given in a double-blind manner as in the first session. Progressive and profound respiratory depression occurred with fentanyl administration alone. In the absence of nalmefene, fentanyl converted normal breathing pattern to an irregular breathing pattern. When the subjects were treated with nalmefene prior to fentanyl administration, all of these changes were almost completely prevented. Pulmonary variables which reflected this difference between the fentanyl-alone group and the nalmefene-pretreated groups included frequency (p less than 0.001), tidal volume (p less than 0.001), percent rib cage contribution to tidal volume (p less than 0.001) and expiratory time (p less than 0.001). This study showed that nalmefene is an effective long-acting opioid antagonist, and that RIP accurately measures changes in respiration caused by opioid administration.
Adult↗
Influence of family functioning on maternal-fetal attachment.
Although the development of a positive relationship between the mother and infant most likely begins during pregnancy, the correlates of maternal-fetal attachment are poorly understood. This study examined the influence of family functioning on maternal-fetal attachment in a sample of varied ethnic and socioeconomic backgrounds. The authors surveyed 339 pregnant women in their last trimesters with the Family Adaptability and Cohesion Scales-III (FACES-III), Maternal-Fetal Attachment Scale (MFA), and a demographic interview. On the basis of correlational and regression analyses, the demographic variables of parity, ethnicity, age, education, and occupation of primary wage earner correlated significantly with maternal-fetal attachment. When entered in a multiple regression analysis, parity, ethnicity, and occupation explained 12% of the variance in the MFA scores. The FACES-III total score and the subscale scores of adaptability and cohesion also correlated significantly with scores on the MFA and explained an additional 3% of the variance in the MFA beyond that explained by the demographics. Support of positive family dynamics during pregnancy by health care workers may potentially increase the quality of maternal-fetal attachment.
Adaptation, Psychological↗