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Biomedical subjects

L R Clark

Publications and source records attributed to L R Clark.

33 records · Page 2Linked to original sources

Gastric tuberculosis: a manifestation of acquired immunodeficiency syndrome.

A Haitian man with acquired immunodeficiency syndrome (AIDS), fever, malaise, and diarrhea is described. A computed tomographic (CT) scan showed a retrogastric mass with an associated ulcer. An upper gastrointestinal tract study showed an ulcer with both benign and malignant features. Endoscopy revealed a malignant-appearing ulcer, but cultures and histologic examinations of surgical biopsy specimens indicated gastric tuberculosis. The relationship between tuberculosis and AIDS is discussed.

Acquired Immunodeficiency Syndrome↗

Enhanced pancreatic CT imaging utilizing a geometric magnification technique.

Computed tomography (CT) using a geometric magnification technique was found to improve spatial resolution in phantom studies when compared with conventional third-generation geometry images. The clinical feasibility of using geometric magnification, small focal spot size, and dynamic contrast enhancement was studied in 143 patients referred to CT for clinically suspected pancreatic disease. This population included 46 patients with a normal pancreas and 36 patients subsequently proven to have primary pancreatic carcinoma. Using this new technique in conjunction with dynamic contrast enhancement resulted in high quality pancreatic images. Despite the limitations in tube current associated with a small focal spot size and low total heat capacity of the system, clinical imaging was not adversely affected. Use of the geometric magnification technique is recommended in departments where it is technically feasible.

Adult↗

Iatrogenic sclerosing cholangitis following hepatic arterial chemotherapy infusion.

A case of common hepatic duct stricture secondary to hepatic artery chemotherapy infusion is described. CT and endoscopic retrograde cholangiopancreatography (ERCP) may be used in concert to differentiate this entity from other causes of jaundice--namely, hepatic replacement by tumor, porta hepatis adenopathy, and chemotherapy hepatotoxicity.

Adenocarcinoma↗

The clinical and imaging spectrum of pancreaticoduodenal lymph node enlargement.

Pancreaticoduodenal lymph node enlargement, regardless of cause, has been a source of imaging confusion because of its propensity to mimic pancreatic malignancy yet not cause biliary obstruction. Thirty-eight patients with pancreaticoduodenal adenopathy were imaged with several methods. Pancreaticoduodenal lymphadenopathy could be distinguished from intrinsic pancreatic abnormality on only 44% (14/32) of CT scans and 54% (6/11) of sonograms. Demonstration of intact tissue planes separating adenopathy from pancreas and, to a lesser degree, extrapancreatic vascular displacement were the most helpful diagnostic signs. Surprisingly, 31% of patients had biliary obstruction. Care must be taken in distinguishing metastatic lymphadenopathy from primary pancreatic tumors. The presence or absence of jaundice should not be considered a helpful sign.

Adult↗

Pancreatic imaging.

In this article, the pancreas is evaluated with regard to the controversies surrounding this organ from a clinical standpoint, and an approach to imaging modalities is examined. The roles of computed tomography, ultrasound, endoscopic retrograde cholangiopancreatography, and magnetic resonance imaging are put into proper perspective.

Acute Disease↗

Imaging approach to the suspected renal mass.

The authors present their algorithmic approach to the detection, characterization, and staging of renal masses. Based on classification of urographic findings, the patient may be triaged to the appropriate cross-sectional or invasive imaging modality that will result in the most cost-effective management.

Abscess↗

Hepatic imaging: current status.

The radiologist needs to be aware of the varied appearance of hepatic mass lesions and be prepared to recommend the most cost-effective imaging approach. In this article, the authors discuss their hepatic imaging experience, common pitfalls, and current recommendations.

Biopsy, Needle↗

Controversies in the radiologic diagnosis of pelvic malignancies.

Although vast differences exist among the many pelvic malignancies, several unifying concepts emerge from this discussion. First, there is a different role for diagnostic imaging for each type of pelvic malignancy. The radiologist should be aware that although the radiographic findings may be similar, the clinical impact varies greatly with a particular tumor. Second, although clinical staging is notoriously inaccurate, nevertheless diagnostic imaging techniques only improve upon but do not replace it because of false-positive and false-negative results. Third, because of the high false-negative rates of most of the modalities in use, negative studies do not in fact rule out the presence of disease. A surgical procedure may still be needed. Finally, several new techniques, including MRI and transrectal or transurethral ultrasound, may improve the accuracy rates. These developments will probably further enliven the controversies surrounding the radiologic evaluation of pelvic malignancies.

Female↗

Imaging of the liver, biliary tract, and pancreas.

The interaction between the various noninvasive and invasive imaging modalities used to evaluate the liver, biliary tract, and pancreas is demonstrated in this article. By understanding this interaction and correlating noninvasive studies, the clinician will avoid diagnostic redundancy and the need for invasive testing may be reduced.

Adenocarcinoma↗

Perirenal cobwebs: the expanding CT differential diagnosis.

Although initially described as representing collateral venous structures, perirenal cobwebs may be due to a variety of benign and malignant conditions. Six representative cases illustrating the broad differential diagnosis are presented.

Aged↗

Computed tomography of acute renal failure secondary to rhabdomyolysis.

Two patients with rhabdomyolysis and renal failure were imaged with CT. The presence of a striate nephrogram, nephromegaly, and perinephric fluid has not previously been described on CT. Although nonspecific, these findings suggest the diagnosis of acute tubular blockade, and, once identified, administration of additional urographic contrast medium should be avoided.

Acute Kidney Injury↗

Dynamic CT vs 0.5 T MR imaging in the detection of surgically proven hepatic metastases.

Seventeen patients with 52 surgically proven hepatic metastases were studied preoperatively with dynamic CT and 0.5 T magnetic resonance (MR). Dynamic CT detected 38 metastases (73%), and the combination of short echo time (T1-weighted) and T2-weighted pulse sequences detected 46 lesions (88%). Magnetic resonance was also superior at assessing potential resectability. This study suggests that MR excels in detecting and anatomically localizing individual hepatic metastases.

Humans↗