Search PubMed⌕ Search

Biomedical subjects

L R Baxter

Publications and source records attributed to L R Baxter.

65 records · Page 4Linked to original sources
PubMed1986

A possible diurnal variation in trazodone clearance.

Diurnal variations in drug metabolism that have clinical consequences have been described for several drugs used in internal medicine but have not been reported for antidepressants. The long half-lives of most antidepressants may obscure such variations. Trazodone hydrochloride has a short half-life compared with other commercially available antidepressants. The authors measured serum levels of trazodone 11 hours after both 9 a.m. and 9 p.m. equal doses of the medication in individuals who had been on these doses for more than 3 days. For patients on other medications in addition to trazodone, serum levels were significantly higher at 8 a.m. than at 8 p.m. (N = 7, P less than 0.01) and approached significance for patients on trazodone alone (N = 8, P = 0.06). Induction of hepatic microsomal enzymes by the other medications may have exaggerated the tendency for trazodone to show diurnal variations in serum levels.

Adolescent↗
PubMed1985

Cerebral metabolic rates for glucose in mood disorders. Studies with positron emission tomography and fluorodeoxyglucose F 18.

Cerebral metabolic rates for glucose were examined in patients with unipolar depression (N = 11), bipolar depression (N = 5), mania (N = 5), bipolar mixed states (N = 3), and in normal controls (N = 9) using positron emission tomography and fluorodeoxyglucose F 18. All subjects were studied supine under ambient room conditions with eyes open. Bipolar depressed and mixed patients had supratentorial whole brain glucose metabolic rates that were significantly lower than those of the other comparison groups. The whole brain metabolic rates for patients with bipolar depression increased going from depression or a mixed state to a euthymic or manic state. Patients with unipolar depression showed a significantly lower ratio of the metabolic rate of the caudate nucleus, divided by that of the hemisphere as a whole, when compared with normal controls and patients with bipolar depression.

Adult↗
PubMed1985

Two cases of obsessive-compulsive disorder with depression responsive to trazodone.

Two patients with severe obsessive-compulsive disorder with superimposed depression, who had failed to respond to a wide variety of antidepressants, were treated with trazodone hydrochloride. Both seemed to obtain a rapid and impressive improvement in both their depression and obsessive-compulsive disorder while receiving trazodone. One patient subsequently had a monoamine oxidase inhibitor added to his treatment and experienced some additional improvement, but most of his improvement had occurred earlier, while he was receiving trazodone only.

Adult↗
PubMed1984

Clinical utilization of the dexamethasone suppression test in an inpatient setting.

In 100 consecutive admissions to an inpatient psychiatric ward, results of the dexamethasone suppression test significantly influenced both treatment and discharge diagnosis. In contrast, MMPI results had no such effect. A positive DST correlated with a diagnosis of, and biologic treatment for, major affective disorder. A negative DST correlated with other diagnoses and the use of nonbiologic treatments, but may have been used incorrectly as evidence against the existence of an affective disorder.

Dexamethasone↗
PubMedDate not supplied

Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease.

OBJECTIVE: Cerebral parietal hypometabolism and left-right asymmetry occur early in the course of Alzheimer disease (AD), and the apolipoprotein E type 4 allele (APOE epsilon 4) is a risk factor for familial AD. To determine if APOE epsilon 4 is associated with lowered brain function in nondemented relatives at risk for familial AD, we studied 12 relatives with APOE epsilon 4 and 19 relatives without APOE epsilon 4. We also compared them with seven patients with probable AD. DESIGN: After grouping subjects according to diagnosis and genotype, brain function measures were compared among groups. SETTING: University medical center. PATIENTS: At risk subjects had mild memory complaints, normal cognitive performance, and at least two relatives with AD. Subjects with APOE epsilon 4 did not differ from those without APOE epsilon 4 in mean age at examination (56.4 vs 55.5 years) or in neuropsychological performance (mean Mini-Mental State Examination score, 28.8 vs 29.3). MAIN OUTCOME MEASURES: Cerebral glucose metabolism was measured using positron emission tomography and fludeoxyglucose F 18. RESULTS: Parietal metabolism was significantly lower and left-right parietal asymmetry was significantly higher in at-risk subjects with APOE epsilon 4 compared with those without APOE epsilon 4. Patients with dementia had significantly lower parietal metabolism than did at-risk subjects with APOE epsilon 4. CONCLUSIONS: These results suggest that the inheritance of APOE epsilon 4 is associated with reduced cerebral parietal metabolism and increased asymmetry in non-demented relatives at risk for probable AD. Longitudinal study will determine if glucose metabolic measures provide a means to monitor experimental treatment responses during the early phases of the disorder.

Adult↗