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Journal Article↗
Biomedical subjects
L Price
Publications and source records attributed to L Price.
Effect of nutritional status on the incidence of infection in childhood cancer.
In 52 children with cancer, the effect of nutritional status on infection rate was studied. Thirty-two children had solid tumors and 20 had leukemia. Their treatment courses were arbitrarily divided into 3-month periods. Where treatment lasted for 9 months or more, the initial Nutritional Status score was correlated with infection rate during the subsequent 3-month period. Among the leukemic patients, a statistically significant inverse correlation (P < 0.05) was found between nutritional status and ensuing infection rate. No such correlation was found in children with solid tumors. Based on these findings, we recommend nutritional support to children with leukemia during chemotherapy to attempt to reduce the infection rate.
Antineoplastic Combined Chemotherapy Protocols↗
The comparative pharmacokinetics and pharmacodynamics of cisplatin and carboplatin in paediatric patients: a review.
Cisplatin and carboplatin are important drugs in the treatment of childhood cancers. Extensive data for carboplatin, and more limited results with cisplatin, indicate that there is significant inter-patient pharmacokinetic variability such that adaptive dosing may be necessary for the optimal use of these drugs. Glomerular filtration rate based dosing formulae have been developed for carboplatin and their use is reviewed. Further studies are needed with cisplatin in order to define the reasons for inter-patient pharmacokinetic variability and its relevance in clinical practice. Only very limited data are available on the clinical or molecular pharmacodynamics of cisplatin and carboplatin in paediatric patients. By analogy with adult studies, pharmacologically-guided platinum complex treatment should offer significant advances over empiric dosing.
Adolescent↗