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Biomedical subjects

L Parker

Publications and source records attributed to L Parker.

At least 253 records · Page 14Linked to original sources
PubMedDate not supplied

Isolation and microsequence analysis of a novel form of neuromedin U from guinea pig small intestine.

A multidimensional chromatographic regimen has been used to isolate and purify a peptide showing immunoreactivity for neuromedin U from guinea pig small intestine. Microsequence Edman N-terminal analysis and C-terminal analysis by enzymatic digestion showed this peptide to be a nonapeptide with the following sequence: H-Gly-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2. The C-terminal octapeptide of this sequence is the same as porcine NMU-8, and the C-terminal heptapeptide is identical to rat NMU(17-23).

Amino Acid Sequence↗
PubMedDate not supplied

Distribution and chromatographic characterization of peptide tyrosine leucine amide (PYLa) immunoreactivity in mammalian tissues.

Using a polyclonal antiserum raised against the mid-region of the abundant amphibian skin peptide PYLa (peptide tyrosine leucine amide) we have shown that immunoreactive PYLa is present in a wide variety of rat tissues, being particularly abundant in the liver, spleen and gut. In each tissue the predominant molecular form corresponds to a moderately hydrophobic, basic peptide of about 10 amino acids. Using the same antiserum in immunohistochemistry we have demonstrated that immunoreactive PYLa was present in endocrine cells, but not neurons, in the ileal mucosa of rat and man. These findings are consistent with an hormonal or local tissue regulatory role for immunoreactive PYLa in the intestine.

Amino Acid Sequence↗
PubMedDate not supplied

Paternal employment in agriculture and childhood kidney cancer.

This paper explores the hypothesis that there is an association between risk of childhood kidney cancer and paternal employment in occupations that have potential for exposure to herbicides and/or pesticides. In contrast to a previous study using paternal occupations at the time of the child's death, no significant association was found between such potential paternal exposures (using paternal occupations at the time of the child's birth) and the risk of cancer of the kidney in childhood (OR 0.88, 95% CI 0.20-3.84). In addition, this paper quantifies the extent to which paternal occupational information on death certificates can be used as a proxy for paternal occupation at birth and how such misclassification could affect risk estimates. An example is given showing how a recently reported association between kidney cancer and paternal agricultural employment may have been overestimated as a result of the use of death certificate information.

Adolescent↗