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Biomedical subjects

L Paris

Publications and source records attributed to L Paris.

30 records · Page 2Linked to original sources
PubMed1990

[Failure of prevention of malaria by mefloquine in West Africa].

Mefloquine (Lariam) is extensively prescribed for the prevention of malaria in chloroquine-resistant areas. However, in west Africa, most of the strains of Plasmodium falciparum are still sensitive to chloroquine. In addition, a few of these strains are inherently resistant to mefloquine. Under these conditions, we must expect to see the failure of mefloquine prophylaxis in travellers returning from west Africa. We report here 5 such failures. The in vitro susceptibility of Plasmodium falciparum isolates from 4 of these patients was evaluated and showed that all 4 had normal sensitivity to chloroquine and quinine, 3 were resistant to mefloquine and one had reduced susceptibility to mefloquine. Mefloquine blood levels (measured 3 times) were within the normal protective range. These case reports indicate that mefloquine should be used cautiously for malaria prevention in west Africa. They also point out that, regardless of the prophylactic method used, fever in a traveller returning from endemic malaria regions always dictates the analysis of a thick blood smear to rule out the diagnosis of malaria.

Adult↗
PubMed1987

Detecting immunoglobulin abnormalities in the cerebrospinal fluid (CSF): which methods are best for clinical purposes?

Several techniques are now available for the quantitative and qualitative examination of CSF proteins modified during the course of neurological disease. The CSF and serum of 42 patients suffering from various neurological diseases and of 7 controls were examined using quantitative methods--single radial immunodiffusion, nephelometric analysis--and qualitative methods--isoelectric focusing on polyacrylamide gel and on agarose gel, isoelectric focusing of unconcentrated CSF followed by transfer to cellulose nitrate membranes and immunoperoxidase staining and double antibody peroxidase labeling and avidin-biotin amplification. In the present study the results and the advantages of different methods are described and compared.

Evaluation Studies as Topic↗
PubMed1981

[Variations in blood serotonin during antiepileptic therapy].

5-OH-tryptamine blood levels, at 8 and 12 a.m., were determined in a 32 epileptics sample, receiving anticonvulsant therapy. As compared to normal controls, 5-HT blood levels in epileptics significatively decreased in the second measurement probably in consequence of anticonvulsant drugs. Moreover 5-HT blood levels decreased more outstandingly in those patients who were treated with more than one anticonvulsant drug. To explain results, two hypotheses are proposed: an inhibiting effect of anticonvulsant drugs on 5-HT catabolizing enzymes, or an increased tryptophan in C.N.S./tryptophan in the blood ratio, induced by therapy.

Adolescent↗
PubMed1976

Lend me your ears.

Explore the source record for details and available documents.

Allergy and Immunology↗
PubMedDate not supplied

Immunologic aspects of carbamazepine treatment in epileptic patients.

Immune abnormalities have been found in epileptic patients receiving antiepileptic drugs (AEDs). Phenytoin (PHT) produces a decrease in serum IgA and IgM levels and a decrease in blastic transformation of circulating lymphocytes stimulated with phytohemoagglutinin (PHA). The effects of carbamazepine (CBZ) on the immune response are still conflicting. To elucidate the effects of CBZ on some immunologic parameters, serum concentrations of IgA, IgG, IgM, the phagocytosis and killing properties of polymorphonuclear leukocytes (PMNs), the cytotoxic activity of natural killer cells and the response of lymphocytes to mitogenic agents were studied. Forty healthy individuals and 39 epileptic patients treated with carbamazepine (CBZ) monotherapy (age range 18-40 years) entered the study. Student's t test was used to evaluate the data. CBZ had no effect on the serum immunoglobulin concentrations or on lymphocytic reactivity to phytohemoagglutinin (PHA) mitogen. CBZ produced a significant enhancement of phagocytosis and killing properties of PMNs and an increase in natural killer (NK) cell activity. Therefore, a negative effect of CBZ therapy on the immune system was not observed in this study.

Adolescent↗
PubMedDate not supplied

[Cystic cervico-dorso-lumbar teratoma].

The authors describe a rare case of teratomatous cervical-dorsal-lumbar cyst. Spinal CT was of particular interest in showing lesion extension and its intramedullary and extramedullary location.

Adult↗