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L Pageler

Publications and source records attributed to L Pageler.

5 recordsLinked to original sources
PubMed2006

Predictors of hazardous alcohol consumption among patients with cluster headache.

The purpose of this study was to identify predictors of hazardous alcohol consumption in patients with cluster headache (CH). We investigated 246 German CH patients with the Alcohol Use Disorders Identification Test (AUDIT). The average daily alcohol consumption was 6.5 g. Predictors for hazardous drinking (AUDIT>or=5 points; 21.5% of patients) were male gender [odds ratio (OR) 4.15, 95% confidence interval (CI) 1.35, 12.71], episodic as opposed to chronic CH (OR 4.8, 95% CI 1.38, 16.67) and a low demanding job as opposed to a high demanding job (OR 2.28, 95% CI 1.15, 4.51). Our data indicate that CH patients drink less alcohol compared with the German population and that CH seems to protect against hazardous alcohol consumption. Moreover, predictors for hazardous alcohol consumption in CH patients are not different from the general population.

Adult↗
PubMed2005

[Migraine].

Explore the source record for details and available documents.

Analgesics↗
PubMed2005

The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel group study.

We investigated efficacy, safety, and tolerability of two tablets of the fixed combination of 250 mg acetylsalicylic acid (ASA) + 200 mg paracetamol + 50 mg caffeine (Thomapyrin) in comparison with two tablets of 250 mg ASA + 200 mg paracetamol, two tablets of 500 mg ASA, two tablets of 500 mg paracetamol, two tablets of 50 mg caffeine, and placebo in patients who were used to treating their episodic tension-type headache or migraine attacks with non-prescription analgesics. For the primary endpoint "time to 50% pain relief" in the intention-to-treat dataset (n = 1743 patients), the fixed combination of ASA, paracetamol and caffeine was statistically significantly superior to the combination without caffeine (P = 0.0181), the mono-substances ASA (P = 0.0398), paracetamol (P = 0.0016), caffeine (P < 0.0001) and placebo (P < 0.0001). All active treatments except caffeine differed significantly (P < 0.0001) from placebo. The superior efficacy of the triple combination could also be shown for all secondary endpoints such as time until reduction of pain intensity to 10 mm, weighted sum of pain intensity difference (%SPIDweighted), extent of impairment of daily activities, global assessment of efficacy. All treatments were well tolerated. The incidence of adverse events observed was low.

Acetaminophen↗
PubMed1999

[Migraine costs and success of non-medicamentous therapy procedures. Relation of diagnostic measures].

BACKGROUND: Migraine is a common neurological disorder (16% women, 6% men) associated with high direct and indirect costs. We evaluated the diagnostic and paramedical therapeutic measures by estimating the expenditure per patient and the effect of treatment. METHODS: A questionnaire was sent to 1000 patients attending the Essen outpatient headache centre in 1995. A total of 293 patients responded, of whom 165 were eligible and could be evaluated. Patients were asked to report diagnostic tests, paramedical treatments applied, average duration of success (defined as meaningful reduction in migraine frequency) and costs of paramedical therapy. RESULTS: Paramedical methods of therapy most frequently used were acupuncture, special pads, relaxation methods and herbal therapy. A total of 579 (3.5 on average) diagnostic procedures such as brain or cervical spine CT and MRI or EEG was performed. The average cost for acupuncture was 465 US dollars, while the success was maintained for 3.2 months. 1510 US dollars was spent on psychotherapy, which was successful for 1.7 months. Patients spent 93 US dollars for relaxation methods, achieving migraine relief for 7.4 months. CONCLUSION: Paramedical treatments lack scientific proof, while both acute and prophylactic treatment strategies have been successfully tested in many clinical trials. Paramedical treatment shows a good temporally effect in individual patients.

English Abstract↗