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Biomedical subjects

L P Kaiushin

Publications and source records attributed to L P Kaiushin.

At least 19 recordsLinked to original sources
PubMed1993

[The compensatory-adaptive mechanisms in nitrite-induced hypoxia in rats].

Concentration of blood proteins, alpha-amino nitrogen, cGMP and endothelin-1,2 was studied in rat's blood at nitric hypoxia. The injection of NaNO2 (5 mg/100 g body weight) was followed by decrease in total protein, albumin and hemoglobin content and by sharp increase in methemoglobin and Hb-NO complexes concentration in rat's blood. Simultaneously, the elevation of free amino acids and peptides with m.w. 2500 D in blood was discovered. One of these peptides was the endothelin-1,2, whose concentration increased twice in plasma at nitric hypoxia. The increase in endothelin and cGMP concentrations is mostly linked with activation of compensative mechanisms, arising as a response to high concentrations of nitro compounds and NO in rats.

Adaptation, Physiological↗
PubMed1978

[Electron paramagnetic resonance study of the products of the reaction between nitrogen oxides and several organic compounds].

A method of electron paramagnetic resonance was applied to the study of a possibility of paramagnetic centres formation in the nitrogen oxide reaction with saturated and unsaturated fatty acids and aromatic amino acids. Several paramagnetic centres are formed in interaction of NO2 with oleic acid at 20 degrees C. Saturated fatty acids formed no paramagnetic centres in the reaction with NO2. NO formed no paramagnetic centres not only with butyric, palmitic, and stearic acids, but also with oleic acid. The capacity of NO2 to form paramagentic centres with tyrosine in its saturated solution was revealed. In case of interaction between NO and NO2 with saturated phenylalanine and tryptophane solutions no formation of paramagnetic centres was observed. It is suggested that unsaturated fatty acids and tyrosine remnants of the membrane lipoprotein complexes could serve as peculiar targets with which NO2 interacted, and that formation of paramagnetic centres in the NO2 reaction with the mentioned substances was the primary act of the membrane damage.

Amino Acids↗
PubMedDate not supplied

[Letter: Study of the interaction of histones F1, F2b, F2a1, F3 with nucleotides by the method of high resolution nuclear magnetic resonance].

Interaction of nucleotides with histones F-1, F-2b, F-2a1, F-3 have been studied by NMP method. It has been found that the interaction of nucleotides with histones increase in the line F-1. F-2b, F-3, F-2a1. It is suggested that histone F-1 is bound with the nucleotides mainly by electrostatic forces. Bounding of histones F-2a1 and F-3 with nucleotides is due not only to electrostatic sinteractions but also to more specific bonds of the base ring with protein.

Adenosine Diphosphate↗