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Biomedical subjects

L P Gunderson

Publications and source records attributed to L P Gunderson.

12 recordsLinked to original sources
PubMed1995

Endotracheal suctioning of the newborn piglet.

Suctioning of the endotracheal tube (ET) is a necessary procedure to remove secretions and debris that naturally accumulate over time. Endotracheal suctioning protocols often call for the injection of small (< or = 0.5 ml) amounts of normal saline down the ET tube just prior to commencing the suctioning procedure. Comparisons of room temperature and body temperature normal saline injectate protocols and their impact on arterial blood gas parameters and heart rate alterations prior to, during, and following the endotracheal suctioning procedure were conducted. Eleven newborn Yorkshire piglets less than 24 hours of age were randomly exposed to both the room temperature (RT) and body temperature (BT) normal saline suctioning protocols. The analysis and interpretation of the results revealed that the RT normal saline injectate caused a greater decline in heart rate and greater alterations in arterial blood gas parameters than did the BT normal saline injectate.

Animals↗
PubMed1992

Clinical trials.

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Clinical Trials as Topic↗
PubMed1986

Partially ventilated endotracheal suction. Use in newborns with respiratory distress syndrome.

Ventilator adapters that permit endotracheal suction without disconnection from mechanical ventilation may overcome several of the theoretical contributors to the hypoxia and bradycardia associated with neonatal endotracheal suction. Such an adapter allows for partially ventilated endotracheal suction (PVETS) as opposed to traditional, nonventilated endotracheal suction. To test the clinical value of PVETS using an endhole adapter, changes in transcutaneous partial pressure of oxygen and heart rate were compared during paired PVETS and nonventilated endotracheal suction events on 32 occasions in 11 premature neonates with respiratory distress syndrome. Partially ventilated endotracheal suction was associated with a significant decrease in the incidence and severity of hypoxic events. Partially ventilated endotracheal suction, however, did not affect the incidence of bradycardic events; PVETS had a small but statistically significant effect on reducing the severity of bradycardia. No clear relationship between bradycardic and hypoxic events was evident.

Bradycardia↗
PubMedDate not supplied

Endotracheal suctioning-induced heart rate alterations.

The purpose of the experimental study was to identify mechanical and/or neural factors contributing to the heart rate alterations associated with endotracheal suctioning (ETS). Effects of catheter insertion alone and catheter insertion with the application of negative pressure on the partial pressure of arterial oxygen (PaO2) and heart rate prior to and following vagal blockade with atropine were examined. Eleven newborn swine less than 24 h of age were randomly exposed to (a) suction catheter insertion alone and (b) suction catheter insertion and the application of suction. Preoperatively, the subjects were anesthetized with ketamine and xylazine (.05 mL/kg). The ECG in lead II was recorded on a Gould 2600S recorder. Arterial blood (aB) O2 levels were withdrawn 1 min before and at 20 s, 1 min, 2 min, and 3 min following ETS and analyzed on a calibrated Corning 158 semi-automated aB gas machine. There was a significant decline in PaO2 from baseline at 20 s post ETS in both the no suction and suction protocols, p less than .05. The application of suction caused a greater decline in mean PaO2 (41 torr) compared to no suction (13 torr) at 20 s post ETS which was similar in pattern following vagal blockade (suction: 37 torr; no suction: 2 torr). Following the first pass of the catheter, mean heart rate (HR) declined 14 beats per min with suction and 9 beats per min with no suction. The difference was obliterated following the second pass of the catheter. There was no difference in the HR following vagal blockade.

Animals↗