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Biomedical subjects

L Ovesen

Publications and source records attributed to L Ovesen.

108 records · Page 6Linked to original sources
PubMed1983

Hypothermia in a patient with anorexia nervosa.

A young woman with anorexia nervosa had severe recurrent hypothermia. Initial evaluation revealed a thiamine deficiency. Administration of pharmacologic doses of thiamine improved voluntary food intake, and her temperature normalized. Following the restoration of body weight, withdrawal of supplemental thiamine produced a clinical relapse. After reinstitution of supplemental thiamine, the patient again became asymptomatic until she chose to consume a calorically-restricted diet. With progressive weight loss, hypothermia recurred and was unresponsive to thiamine therapy. Fortuitously, the patient's intake of sucrose was abruptly increased, and her body temperature normalized within seven days. The potential roles of thiamine and carbohydrate in thermoregulation are discussed.

Adult↗
PubMed1983

The influence of dietary fat on jejunostomy output in patients with severe short bowel syndrome.

The effect of diet on jejunostomy output of fluid, fat, sodium, potassium, calcium, magnesium, zinc, and copper was studied in five metabolically stable, home parenteral nutrition patients. Three isocaloric diets were compared; one low in fat (30% kcal) but high in complex carbohydrate (55% kcal), and two high in fat (60% kcal) but low in carbohydrate (25% kcal). The polyunsaturated/saturated fatty acid ratios of the two high fat diets were 1:4 and 1:1. Although increasing the percentage of fat in the diet increased the amount of steatorrhea, altering the polyunsaturated/saturated fatty acid ratio had no clearly beneficial effect on the amount of fat absorbed. Neither the amount of fat, nor the type of fat, had any consistent influence on jejunostomy volume. The sodium and potassium concentration of the jejunostomy fluid stayed remarkably constant and hence net monovalent cation losses reflected jejunostomy volume rather than the fatcarbohydrate content of the diet eaten. The most consistent effect of the high fat diet was a marked increase in ostomy losses of divalent cations; calcium, magnesium, zinc, and copper. Most of the time a net divalent cation secretion on the high fat diet was converted into a net absorption on the low fat, high carbohydrate diet. Altering the polyunsaturated/saturated fatty acid ratio had no consistent effect on divalent cation losses. In conclusion, the proportion of fat versus carbohydrate calories does not appear to influence ostomy volume or monovalent cation loss in extreme short bowel, end jejunostomy patients; however, a high fat intake causes a significant net secretion of divalent cations.

Adult↗
PubMed1982

Reversible neurological symptoms caused by vitamin E deficiency in a patient with short bowel syndrome.

The effect of vitamin E deprivation on the fully developed human nervous system is not known. In children with fat malabsorption from various causes neuropathological and neurological changes have been ascribed to vitamin E deficiency. Herein we described a neurological deficit that occurred in a 64-yr-old man with chronic steatorrhea leading to severe vitamin E deficiency. long-term supplementation with vitamin E resulted in clinical improvement beginning a few months after normalization of his vitamin E status.

Ataxia↗
PubMed1980

Antiarrhythmic properties of a neuroleptic butyrophenone, melperone, in acute myocardial infarction. A double-blind trial.

In vitro animal studies suggest melperone, a neuroleptic butyrophenone, to be a type III antiarrhythmic drug according to the classification of Vaughan Williams. It has no negative inotropic effect on cardiac muscle. A double-blind trial of 3 hours' duration was carried out with melperone and placebo in 26 patients admitted to the CCU with suspected acute myocardial infarction (AMI) and ventricular arrhythmias. Melperone, 50 mg i.v., was superior to placebo in reducing the total number of ventricular ectopic beats (VEB) as well as the number of minutes with either frequent, multifocal, R-on-T-type or runs of VEB. The reduction became statistically significant in the second treatment hour in patients with definite AMI. Melperone induced sedation and reduction of systemic BP in most of the patients. Two patients with low initial systolic BP achieved a further reduction and had BP levels below 90 mmHg. Two patients experienced minor side-effects. In conclusion, melperone administered in large i.v. doses to patients with AMI induced sedation, acute BP reduction and some reduction of ventricular arrhythmia. X

Aged↗
PubMed1979

[Hartnup disease].

Explore the source record for details and available documents.

Diagnosis, Differential↗
PubMed1979

Drugs and vitamin deficiency.

During the past 10 to 20 years it has become increasingly clear that a certain number of drugs may lead to increased vitamin requirements. However, it is unusual for symptomatic avitaminosis to develop, and then only when circumstances are present which in themselves increase the risk of vitamin deficiency. Therapeutic doses of drugs will interfere with the vitamin status only to a restricted degree, provided they are administered for brief periods and to patients receiving a normal supply of vitamins. Most cases of vitamin deficiency have in fact been described in connection with drugs usually taken for a longer period of time by patients who were already in negative vitamin balance as a result of disease or marginal supply of the necessary vitamins. This review describes some of the more important articles covering this topic.

Ascorbic Acid Deficiency↗
PubMedDate not supplied

Changes in lipoprotein cholesterol distribution in weight-stable postjejuno-ileal bypass patients.

The influence of the jejuno-ileal bypass procedure upon serum lipoproteins was investigated. Lipoprotein cholesterol distribution was measured in 12 jejuno-ileal bypass subjects. The results were compared to 12 obese controls and 12 normal weight controls. In the bypass group, total cholesterol and low density lipoprotein cholesterol concentration was significantly reduced compared to both control groups. The high density lipoprotein cholesterol concentration in the bypass group was not significantly different when compared to the obese control group and in fact both obese groups had high density lipoprotein cholesterol levels significantly less than the normal weight controls. In the bypass group, the high density lipoprotein/low density lipoprotein cholesterol ratio was significantly increased compared to both control groups. These findings suggest a decreased atherogenic potential in jejuno-ileal bypass patients.

Adolescent↗
PubMedDate not supplied

The effects of oral soybean phospholipid on serum total cholesterol, plasma triglyceride, and serum high-density lipoprotein cholesterol concentrations in hyperlipidemia.

In a randomized, double-blind, cross-over trial soybean phospholipid and placebo, 18 g daily for 6 wk, were given orally to 20 patients on long-term treatment with standard lipid lowering diets. The effect of this treatment on serum total cholesterol and high-density lipoprotein cholesterol and plasma triglyceride was studied. After 6 wk mean (+/- SE) cholesterol concentration was decreased by 0.54 (+/- 0.19) mmol/liter in phospholipid-treated as compared to placebo-treated patients (p less than 0.02). The decrease in serum cholesterol was significant (p less than 0.02) only in patients assigned to receive phospholipid before placebo. A highly significant increase (p less than 0.001) followed the withdrawal of phospholipid. No effect on triglyceride and high-density lipoprotein cholesterol concentrations was demonstrated.

Administration, Oral↗
PubMedDate not supplied

Different quantities of two commercial liquid diets consumed by weight-losing cancer patients.

Twenty ambulatory, weight-losing patients with advanced cancer of the lung, breast, or ovary were randomized to supplement their diet for 2 months with either of two commercial complete liquid diets, one containing intact milk proteins and the other partially hydrolyzed soy proteins. Both products were prescribed as sip feeds in addition to normal food. The patients consumed more of the hydrolysate-containing product than of that with intact (milk) protein. The difference was significant and was maintained during both months of the study. An increase in total energy and protein was obtained in both groups, but was significant only with the hydrolysate product. At the end of the study there was no group difference in measures of nutritional status, but weight loss was halted in both groups.

Adult↗