Biomedical subjects
Publications and source records attributed to L Olmos.
Study of the histiocytes from a large variety of skin diseases demonstrates a close relationship between the cell processes peculiar to those cells and their degree of phagocytic activity. The membrane structures, as well as the dense bodies localized in the peripheral cytoplasm, suggest a type of endocytosis distinct from pinocytosis and phagocytosis.
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The authors observed one case of plasmocytic reticulosis which was noticable by its strictly left unilateral localisation, involving the face, the underscapular region, the shoulder and the elbow, the leg with an important augmentation of the left foot. Histologically, dense plasmocytic infiltration can be observed without anomalies. Electron microscopy confirmes the presence of plasmocytes at any stage of activity without monstruosities. This observation can not be classified in the forms that are actually described: Klüken's and Simonis' plasmocytic reticulosis, plasmocytomas with osseous and medullar lesions, extramedullar plasmocytoma.
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Clinical, histopathologic, and ultrastructural observations in a patient who developed all the characteristics of the Stewart-Treves syndrome 25 years after mastectomy has convinced the authors that the neoplasm arises as a glandular metastasis after an initial phase of sclerosis and that the neoplastic cells are of myoepithelial type.
A randomized, double-blind, placebo-controlled trial was conducted to assess interferon-beta efficacy and safety in the treatment of anogenital condylomatous lesions. One hundred patients received a daily intramuscular injection of either interferon-beta (IFN-beta) (2 MIU/day) or placebo for 10 days. Of 94 evaluable patients, the complete response rate observed 8 weeks after treatment was significantly higher in the group receiving IFN-beta, as compared to the placebo-treated group (51% vs 28.9%, P < 0.05). After one year, 24 patients (100%) out of 24 complete responders to IFN-beta who attended for follow-up remained free of lesions. Twelve of 13 patients with complete response to placebo (92.3%) remained free of lesions after one year. Side effects were mild and no significant analytical changes were observed. In conclusion, interferon-beta is an effective and safe treatment for long-term eradication of anogenital condylomatous lesions.
Three hundred and ten patients, 129 under sixty-five years (group A) and 181 over this age (group B), were studied to determine the clinical differences between young and elderly patients with acute myocardial infarction. Women were significantly more present in group A and heavy smokers in group B. Hypertension, although not significantly, was more frequent among the elderly. Serial ECG and enzyme determinations followed the same classic pattern in both groups. Age did not influence neither the localization of the infarction nor the incidence of subendocardial infarction. Young patients remained more often in functional class I, whereas class IV was twofold more frequent among the older. First and second degree A-V block were equally present in the two groups, while third degree A-V block was significantly more frequent in patients over 65. Finally, as expected, in-hospital mortality was significantly higher (34% vs 16% p less than 0.001) among the older patients.
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