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Biomedical subjects

L Oldrizzi

Publications and source records attributed to L Oldrizzi.

64 records · Page 4Linked to original sources
PubMedDate not supplied

Hypertension and progression of renal disease.

That systemic hypertension is involved in the progression of human renal disease is mostly suggested by the way anti-hypertensive treatment affects the course of the disease. Clinical evidence has been obtained from observational studies as well as from studies of dietary protein restriction. In addition, several trials have compared the effects of different antihypertensive agents. The angiotensin-converting-enzyme inhibitors have the best renoprotective effect when compared to conventional agents and calcium channel blockers. In most studies, ACE-inhibitors approximately halved the risk of progressive renal functional deterioration in patients with non-diabetic nephropathies; this protection was associated with a significant reduction in systemic blood pressure and proteinuria. Statistical analysis, however, also suggests a direct effect of ACE-inhibitors on the kidney.

Angiotensin-Converting Enzyme Inhibitors↗
PubMedDate not supplied

Dietary therapy in chronic renal failure. (A comedy of errors).

Controversies still exist about the use and the effects of low protein diets in chronic renal failure. The contrasting - sometimes opposite - results published over the last 30 years in several studies can be read and explained by a series of errors included in those studies. The new Comedy of Errors starts from the misinterpretation of experimental studies, the lack of appropriacy of clinical trials' design; it continues with neglecting the role of patients' compliance as well as of other clinical findings, here included the role of blood pressure. Finally pitfalls in the intrepretation of the results of clinical trials and meta-analyses were identified.

Antihypertensive Agents↗
PubMedDate not supplied

[Risk factors for the progression of chronic kidney failure].

Virtually all renal diseases progress, although at different rates, to end-stage renal failure. The main clinical factors which may explain such relentless progression are reviewed and include: the underlying renal pathology, with the most rapid progression rate observed in glomerular disease and in polycystic kidney disease; systemic hypertension, a significant risk factor for progression in any renal disease; the magnitude and duration of proteinuria with the fastest progression rate found in the nephrotic syndrome; the degree of functional renal deterioration at which so called conservative treatment is prescribed. The proper identification of these risk factors may result in rational dietary and non-dietary intervention with the aim of slowing the progression of chronic renal disease.

Humans↗