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Biomedical subjects

L Okmian

Publications and source records attributed to L Okmian.

At least 37 records · Page 2Linked to original sources

Artificial ventilation in children during anaesthesia using a tidal volume ventilator.

Standards for artificial pulmonary ventilation at ventilatory frequencies of 15 and 20 cycles per min, (PETCO2 4 +/- 0.5 kPa), were defined in 16 children with healthy lungs and body weights between 2.6 and 22.6 kg. A tidal volume ventilator and balanced anaesthesia were used during abdominal surgery. At f = 20 cycles/min an approximately direct proportionality existed between tidal volume and body weight (VTpat = 12.3 . kg b.w.--2.1, r = 0.99). The mean value VTpat per kg b.w. was 12.1 +/- 1.4 ml/kg. At f = 15 cycles/min, a linear relationship between tidal volume and kg b.w. was recorded (VTpat = 14.6 . kg b.w. + 16, r = 0.97). The mean value VTpat per kg b.w. was 15.9 +/- 1.5 ml/kg. A significant decrease in total compliance was recorded during the initial part of the surgical procedure. A rectilinear relationship existed between total compliance and kg b.w. (CTOT = 11.2 . kg b.w.--12.5, r = 0.95). The mean value CTOT per kg b.w. was 9.7 +/- 0.54 ml/kPa/kg at f = 20. The endotracheal peak pressure maintained a fairly constant pressure level independent of the initial pressure within the ventilator, the tidal volume and the body weight, a phenomenon explained by the hypothesis that the proportional increase in total lung volume and functional residual capacity in the older children compensated for the higher pressures.

Abdomen↗

Oesophageal clamp anastomosis and stricture formation. An experimental study in the piglet.

End-to-end oesophageal anastomoses were performed with a metal clamp in 8 piglets. A transanastomotic catheter was kept in position for 5 weeks following release of the clamp. The results were evaluated by contrast radiography after a further 2 weeks. All the animals survived the operation and the pre-determined observation period. All the anastomoses healed without signs of leakage. They showed strictures of varying degrees, as assessed by radiography of the specimens. The dissected specimens showed scarred changes in the anastomoses where the thin mucosa was regenerated. The results are explained by the fact that the method of clamp anastomosis per se leads to a mucosal defect at the site of anastomosis with ensuing secondary wound healing. The intraluminal tube therby prevents wound contraction with luminal obliteration by giving the mucosa time to regenerate.

Animals↗

Renal blood flow and function during neuroleptanaesthesia and at elevated intravesical pressure. An experimental study in the pig.

During two hours of neuroleptanaesthesia in five pigs, renal blood flow was unchanged, whereas renal vascular resistance and the mean arterial blood pressure increased. The glomerular function was not significantly altered. The tubular function was moderately impaired. The intravesical pressure was successively elevated in seven pigs. This caused no changes in renal blood flow. The renal vascular resistance increased parallelled by a slight increase of the mean arterial blood pressure. Both glomerular and tubular function decreased when the intravesical pressure was elevated to 50 mm Hg or above.

Animals↗

Renal blood flow and function at elevated ureteric pressure. An experimental study in the pig.

The unilateral ureteric pressure was successively elevated in five piglets. Bilateral studies of renal blood flow and related parameters (cardiac output, renal vascular resistance, mean arterial and mean venous blood pressures) revealed no significant changes. At a unilateral ureteric pressure of 10 mm Hg, there was a temporary decrease in the renal vascular resistance in both kidneys concomitatnt with an increase in renal blood flow. Glomerular and tubular function decreased successively as the unilateral ureteric pressure was increased. At a retrograde pressure of 75 mm Hg, some renal function was still preserved, probably due to pyelolymphatic backflow.

Animals↗