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Biomedical subjects

L O Badalian

Publications and source records attributed to L O Badalian.

At least 19 recordsLinked to original sources
PubMed1997

[Nerve tissue-specific proteins in the assessment of the permeability of the hemato-encephalic barrier in comatose states in children].

The role of functional state of hematoencephalic barrier (HEB) was estimated in terms of development of pathological process in coma. The quantitative determination of neurospecific protein (NSP), exactly of alpha 1 and of alpha 2 cerebral globulins (produced by astrocytes and oligodendroglial cells) was used for estimation of HEB state. The clinical examination of 138 children in comatose state caused by different factor (meningitis, encephalitis, cerebrocranial trauma, infectious toxicosis) was performed. Enzyme immuno-assay of alpha 1 and of alpha 2 cerebral globulins allowed to control HEB's functional state objectively in "brain-blood" direction: in cases of alteration of HEB's function the autoantibodies to NSP may penetrate into cerebral tissue and cause nonspecific reaction in form of edema or inflammation. The membrane stabilizing effect of Dexamethazone was established.

Acute Disease↗
PubMed1995

[The use of the Lüscher color test for assessing the emotional status of children and adolescents with an organic central nervous system lesion and borderline psychopathology].

The diagnostic value of Lüscher's colour test for the estimation of emotional state of children and juveniles (teenagers) with central nervous system's organic alteration and borderline psychopathological disturbances was analysed. Moreover a number of other additional tests were used namely the colour estimation of current and optimal state, the measurement of personal emotional anxiety according to Scott scale as well as the comparison of colour selection results and colour perception in dream. It was demonstrated that color selection results depended upon both neuroticism level and presence or type of psychopathological disturbances. They had their own specificity if organic CNS alteration took place and were determined by pathological focus localization. The psychological characteristics that were symbolized in colours according to Lüscher corresponded mainly to personal peculiarities in both neurosis-like and certain types of psychopathological alteration in which the definite colours were preferable.

Adolescent↗
PubMed1995

[West syndrome in tuberous sclerosis].

Observation's analysis of 5 children in age from 9 months to 4 years 11 months with tuberous sclerosis was performed. The initial manifestations of disease were following: early children form of epilepsy exactly infantile spasms (West syndrome) appearance, dermal alterations in the form of depigmented spots as well as nonprogressive delay in psychoverbal development. Together with clinical symptoms the main criterion in early form of tuberous sclerosis diagnosis determination turned out to be brain's specific alterations (tubers) which were revealed by computer tomography. The correlation was observed between epileptic seizures polymorphism and frequency as well as brain's morphological alterations. Derivatives of valproic acid were the basic drugs in treatment of epileptic seizures in patients.

Anticonvulsants↗
PubMed1994

[The enkorat treatment of infantile spasms and the Lennox-Gastaut syndrome].

The drug encorat, an analogue of valproic acid (Sun, India) was given to 16 children aged from 4 month to 5 years suffering from resistant forms of early infantile epilepsy. Twelve of them had infantile spasms, four Lennox-Gastaut syndrome. The treatment produced good results in 75% of the patients. Encorat mono- or polychemotherapy is able to discontinue or decrease the frequency of the epileptic fits, improve the patients' condition in resistant early childhood epilepsy.

Anticonvulsants↗
PubMed1994

[The study of dreams in a complex method for the neuropsychological examination of children and adolescents with organic lesions and functional disorders of the CNS].

The dreams were analyzed in 73 patients aged 10-14, among them 22 had brain tumors, 23 epilepsy, 18 neurotic and psychopathic-like disturbances. The control group included 10 healthy children. The results showed that the frequency and pattern of the dreams are related to functional disturbances secondary to the organic lesions of the brain as well as to organic lesions themselves and relevant location. Correlation between dream features and psychologic characteristics of the patients has also been demonstrated.

Adolescent↗
PubMed1994

[The neurological syndromes in Lyme disease in children].

Clinical characteristics of Lyme disease (LD) course in children have been studied. Altogether 86 patients were examined. Serodiagnosis was made in patients basing on indirect immunofluorescence and enzyme immunoassay with LD agent antigens. Erythema--free forms, combination of mite-borne Borrelia infection with tick-borne encephalitis were detected. Two clinicoimmunological LD variants were verified: seropositive and seronegative mite-borne Borrelia infection with typical clinical manifestations. The disease took a benign course responsive to antibiotics in combined treatment of neuromuscular lesions.

Adolescent↗
PubMed1993

[Temporal-lobe epilepsy with psychosensory and gustatory attacks].

A variety of temporal epilepsy that manifested by paroxysms in the form of psychosensory and gustatory ones is described. A 20-year-old man was placed under observation. Since 14 years of age he demonstrated attack-like conditions with a sensation of the pushing apart and swelling in the head, of an increase of the head size, and unpleasant sickly sweet taste in the mouth. The attacks were accompanied by anxiety and general weakness. Neurological examination revealed left-handed hemisymptomatology, EEG demonstrated activity prevailing in the occipitotemporal leads on the right. The neuropsychological findings attested to the impairment of the structures of the right temporal lobe. Analysis of the clinical manifestations of epilepsy, of the neurological findings, and the neuropsychologist's conclusion made it possible to suggest the site of the epileptic focus in the field of the hippocamp on the right.

Adult↗
PubMed1993

[The characteristics of the immune status of patients with Alzheimer's disease].

Disorders seen in patients with Alzheimer's disease are also related to the pathology of immunity. In order to study it in a more detailed manner, some immunity parameters were examined in 30 patients with Alzheimer's disease, 15 patients with Huntington's chorea which may have similar mechanisms of immunologic defects, and 15 healthy donors. A study was also made of the capacity of peripheral blood lymphocytes to respond to polyclonal mitogens in blast transformation test and according to the production of immunoglobulins in vitro. The subpopulation composition of these cells was investigated as well. A significant rise of the count of C 8+ lymphocytes, depression of proliferative response, low spontaneous and high Phytolacca mitogen-stimulated immunoglobulin production have been revealed. The changes recorded in Huntington's chorea had the same nature of development. The disorders revealed allow a conclusion about an important role that may be played by the immune system in these degenerative diseases of the brain.

Alzheimer Disease↗
PubMed1993

[Neuro-AIDS in children].

The paper analyzes the results of studying nervous diseases in children with HIV infection. A total of 57 children aged 1.5 to 16 years who had different stages of AIDS were examined. HIV-related encephalopathy, encephalopathy with the polyneuropathy syndrome, encephalomyelopolyneuritis, mixed AIDS-related encephalopathy and perinatal encephalopathy, as well as the myopathic syndrome were identified. The affliction of the nervous system was more severe with an earlier history of infection. The clinical syndromes were supported by electromyographic indices.

AIDS Dementia Complex↗