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Biomedical subjects

L Niskanen

Publications and source records attributed to L Niskanen.

113 records · Page 7Linked to original sources
PubMed1989

Compartment syndrome as a late complication of eosinophilic fasciitis.

Eosinophilic fasciitis (EF) was diagnosed in a 23-year-old man presenting characteristic symptoms, skin changes, blood eosinophilia and typical histology showing thickened deep dermal fascia with inflammatory cells. After one year of corticosteroid treatment he experienced increasing pain in both legs and fluctuating serum creatinine kinase levels. Direct measurement showed elevated resting intracompartment pressure and both static strain and dynamic exercise provoked the typical pain. At operation all 4 compartments of both legs were decompressed and he recovered uneventfully. The compartment syndrome may be a hitherto unknown, but expected complication of severe EF.

Adult↗
PubMed1987

Macrovascular complications in relation to hyperinsulinaemia in non-insulin-dependent diabetes mellitus.

Despite suggestive evidence from studies on experimental pathology and cell biology of the arterial wall and from clinical and epidemiological studies on non-diabetic subjects indicating that hyperinsulinaemia might be associated with an increased risk of atherosclerotic vascular disease (ASVD) information concerning the role of hyperinsulinaemia as a risk factor of ASVD in diabetic patients still is circumstantial. A few cross-sectional and still fewer prospective studies in patients with non-insulin-dependent diabetes (NIDDM), including two ongoing studies carried out by our own research group, have shown associations between hyperinsulinaemia and the occurrence of ASVD, but these data still are far from consistent and conclusive. Further studies applying combined clinical and epidemiological approach, building upon the results of experimental research concerning possible mechanisms, are needed for better clarification of the role of hyperinsulinaemia as a risk factor of ASVD in NIDDM.

Adult↗
PubMed1987

Hyperinsulinemia and hypertension in patients with newly diagnosed non-insulin-dependent diabetes.

An increased occurrence of hypertension was observed in a group of patients (N = 133) with newly diagnosed non-insulin-dependent diabetes as compared to non-diabetic control subjects (N = 144). In men the excessive occurrence of hypertension in diabetics seemed to be mainly confined to obese subjects, whereas in women it occurred both in obese and non-obese subjects. Fasting or postglucose serum insulin levels showed a positive correlation with blood pressure levels in non-diabetic men and in diabetic and non-diabetic women even after adjustment of insulin for obesity.

Analysis of Variance↗