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Biomedical subjects

L Nilsson

Publications and source records attributed to L Nilsson.

At least 433 records · Page 24Linked to original sources
PubMed1975

Effects of hypothermia and hyperthermia on brain energy metabolism.

The influence of elevated and reduced body temperatures upon the metabolic state of the brain was evaluated from the tissue concentrations of phosphocreatine (PCr) ATP, ADP and AMP and from the concentrations of glucose, lactate and pyruvate in immobilized and artificially ventilated rats anesthetized with 70% N2O. The results were compared to the results obtained in normothermic animals. It was found that rats with body temperatures of 32 degrees and 22 degrees C had the same brain tissue concentrations of high energy phosphates and the same adenylate energy charge as the controls, but hypothermia led to a progressive decrease of both cerebral and arterial lactate and pyruvate concentrations. A metabolic acidosis but no excess lactate appeared in the blood. At a body temperature of 42 degrees C, the metabolic pattern in the brain agreed with a state of hypoxia at a time when there was no sign of substrate depletion. Arterial blood showed excess lactate which may indicate an inadequacy of the oxygen supply also to other tissues.

Adenosine Diphosphate↗
PubMed1975

The effect of phenobarbitone anaesthesia on blood flow and oxygen consumption in the rat brain.

The influence of phenobarbitone anesthesia on blood flow (CBF) and oxygen consumption (GMRO2) was evaluated in the rat brain, using a method that quantitatively measures CBF in mainly cortical areas. The data were compared to those obtained in animals under fentanyl citrate analgesia. Body temperature and arterial CO2 tension were maintained close to normal values in all groups. With 50 mg/kg of phenobarbitone, CBF and CMRO2 were reduced by about 20%. With 150 or 250 mg/kg, further reductions in CBF and CMRO2 were observed. At 250 mg/kg, CBF was reduced to one third, and CMRO2 to about 50% of normal. The results suggest that little further reduction in CBF or CMRO2 can be expected if the dose of phenobarbitone is increased above 250 mg/kg.

Anesthesia, General↗
PubMed1975

The longitudinal course of para-natal emotional disturbance.

Ninety-five nulliparous women were interviewed during pregnancy and 4 months post partum. The possibility of predicting mental disturbance post partum from that during pregnancy was studied. When the woman was mentally disturbed during pregnancy, the prognosis was better in the case of a poor social situation at the time of the pregnancy than in the case of a good social situation. Negative attitude towards further pregnancies and repudiation of the own mother, however, implied unfavourable prognosis. In the case of a woman without mental symptoms during pregnancy, denial of the pregnancy and sensations connected with it suggested poor adaptation post partum.

Adult↗
PubMed1975

Effects of LH and HCG on the metabolism of the prepubertal rat ovary: stimulation of amino acid transport, protein synthesis, and glycolysis.

It has earlier been reported from this laboratory that FSH can stimulate amino acid uptake, protein synthesis and glycolysis in the isolated prepubertal rat ovary. In the present investigation to the effects of LH and HCG were studied. The hormones were injected to prepubertal female rats, and the ovaries were extirpated for incubation in Krebs bicarbonate buffer 120 min later. Injected of 1 mu g/100g body weight of a bovine LH preparation (NIH-LH-B8) produced a significant increase in the in vitro uptake of (14C) alpha-amino-isobutyric acid (14C)AIB) and (3H)leucine as well as of the incorporation of radioactivity into the ovarian protein. Higher doses (10 and 100 mu g) of NIH-LH-B8 gave only minor futher increases. Lactic acid production during the incubation period was also measured as a determination of the rate of glycolysis. Lactic acid production was stimulated by the LH injections with a clear dose-response between 0.1 and 10 mu g/100 g body weight. The effects of LH were also investigated with shorter intervals between the injection of the hormone and the extirpation of the ovaries. While lactic acid production was maximally stimulated at a time interval of 30 min (the shortest time interval studied), 60 min was necessary for the stimulation of amino acid uptake and amino acid incorporation into protein. Injections of HCG mimicked the effects of LH on all parameters studied.

Aminoisobutyric Acids↗