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Biomedical subjects

L Nichols

Publications and source records attributed to L Nichols.

59 records · Page 4Linked to original sources
PubMedDate not supplied

Aflatoxin content of foods served to a population with a high incidence of hepatocellular carcinoma.

During three seasons, 36 samples of foods served to mentally retarded clients with a high incidence of hepatocellular carcinoma were analyzed for aflatoxin. Aflatoxin was not detected (less than 5 ppb) by thin-layer liquid chromatography in 35 food samples containing peanuts, corn, wheat or milk. One peanut butter sample contained 20 ppb aflatoxin. Aflatoxin content of these foods was at or below the level permitted by the Food and Drug Administration. Aflatoxin is probably not responsible for liver disease in this population.

Aflatoxins↗
PubMedDate not supplied

Experience with cefsulodin therapy for lower respiratory tract infections caused by Pseudomonas aeruginosa in adults without cystic fibrosis or granulocytopenia.

Cefsulodin was administered as the sole antipseudomonal therapy to 14 adults without cystic fibrosis or granulocytopenia for infection of the lower respiratory tract caused by susceptible strains of Pseudomonas aeruginosa. At dosages of 1.0-1.5 g intravenously every 6 hr, peak serum antipseudomonal activity consistently exceeded 1:16. Twelve patients (86%) showed a favorable therapeutic response: six (43%) with eradication of P. aeruginosa from the respiratory tract and six (43%) with persistent colonization. Two patients (14%) did not respond to cefsulodin therapy. In five cases (36%), P. aeruginosa resistant to cefsulodin appeared during the course of therapy, in two cases contributing to therapeutic failure; three strains also acquired cross-resistance to two or more other antipseudomonal beta-lactam antibiotics. Cefsulodin was well tolerated, with no evidence of organ toxicity or other adverse effects discerned. These therapeutic results are comparable with or superior to those reported with other antipseudomonal drugs studied in single-drug regimens for treatment of P. aeruginosa lower respiratory tract infections in this patient population.

Adult↗
PubMedDate not supplied

Interlocking intramedullary nailing of femoral-shaft fractures in adolescents: preliminary results and complications.

Thirty-one femoral-shaft fractures in 30 patients were treated with interlocking intramedullary nails. The 19 boys and 11 girls ranged in age from 10 to 15 years (average age 12 + 3 years) at the time of injury. All fractures united, and the average leg-length discrepancy (comparing the injured to the uninjured extremity) was 0.51 cm. Two patients had overgrowth of > 2.5 cm; none had angular or rotational malunions. One patient developed asymptomatic segmental avascular necrosis of the femoral head, which was not seen on radiographs until 15 months after injury. All nails were removed at an average of 14 months after injury; no refracture or femoral neck fracture has since occurred. Intramedullary nailing is a reasonable alternative for the treatment of isolated femoral-shaft fractures in older adolescents and in younger adolescents with multiple trauma.

Adolescent↗