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Biomedical subjects

L Ng

Publications and source records attributed to L Ng.

62 records · Page 4Linked to original sources
PubMed1978

The binding of lithium and of anionic metabolites to phosphoglucomutase.

Intercept inhibition of rabbit-muscle phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate: alpha-D-glucose-1-phosphate phosphotransferase, EC 2.7.5.1) produced by several nucleotide diphosphates and compounds related to coenzyme A was re-examined in order to re-evaluate an earlier suggestion that this enzyme has an allosteric regulatory site. However, in all cases intercept inhibition constants were much larger than those previously reported, and in all but two cases were too large to assess in the assay system, i.e., were greater than 10 mM. Most of the intercept inhibition previously observed apparently was caused by the use of the Li+ salts of inhibitors. Thus, Li+ binds competitively with the natural activator, Mg2+, and in the presence of glucose phosphates binds almost as well as Mg2+: Kd approximately 10 micrometer. The observation that glucose phosphates bind to the Li+ complex of phosphoglucomutase some 900 times more tenaciously than to the corresponding Mg2+ complex could provide a partial rationale for the lack of reactivity of the Le+ form of the enzyme. Attempts to verify the dimeric structure of phosphoglucomutase that was previously reported also produced negative results.

Binding Sites↗
PubMedDate not supplied

The development and evaluation of a disease-specific quality of life measurement tool for shoulder instability. The Western Ontario Shoulder Instability Index (WOSI).

The purpose of this study was to develop a valid, reliable, and responsive disease-specific quality of life measurement tool for patients with shoulder instability. Development included 1) identification of a specific patient population; 2) generation of issues specific to the "disease" ("items") from reviewing the literature, interviewing health caregivers, and interviewing patients representing all demographics, disease type and severity, and treatments; 3) item reduction using patient-generated frequency-importance products and correlation matrices; and 4) pretesting the prototype instrument on 2 groups of 10 patients. The final instrument, the Western Ontario Shoulder Instability Index, has 21 items representing 4 domains. The instrument attributes (validity, reliability, and responsiveness) were evaluated. Construct validation demonstrated that this index correlated predictably with other measures. Reliability was very high at 2 weeks and 3 months, and the index was more responsive (sensitive to change) than five other shoulder measurement tools (the Disabilities of the Arm, Shoulder and Hand scale; The American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form; the UCLA Shoulder Rating Scale; the Constant Score; and the Rowe Rating Scale), a global health instrument (the SF12), and range of motion. Since the patient's perception of changes in health status is the most important indicator of the success of a treatment, we suggest that this measurement tool be used as the primary outcome measure to evaluate treatments in this patient population, although it can also be used for monitoring patients' progress in clinical practice.

Demography↗
PubMedDate not supplied

Nursing aspects of the surgical treatment of idiopathic hypertrophic subaortic stenosis.

Preoperative and postoperative nursing assessments and interventions of patients with IHSS are similar in principle to those for other adult patients undergoing cardiac surgery. The potential complications following left ventriculomyotomy-myectomy are identified in Table III. The complications are paralleled with major nursing interventions. In summary, IHSS patients specifically are at greater risk of preoperative sudden death and postoperative dysrhythmias which warrants discriminating nursing observation.

Adolescent↗
PubMedDate not supplied

[Changes in the content of opiate-like substances in auricular electroacupuncture anesthesia of rats].

It was shown that auricular electro-acupuncture in rats, sufficient to induce analgesia, resulted in a significant increase of endorphins in cerebro-spinal fluid with a concomitant decrease in the basomedial hypothalamus and medial thalamus of beta-endorphin-like immunoreactivity as well as endorphin-like radioreceptor activity. In addition, the radioreceptor assay also revealed a decrease of endorphin-like radioreceptor activity in the periaqueductul gray matter. plasma levels of endorphins were not altered. Cerebro-spinal fluid contained only endogenous opiate ligand material with enkephalin-like molecular weight.

Acupuncture Therapy↗